Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.14/43481 |
Resumo: | Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes. |
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Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucinAnti-inflammatoryEdemaPharmacological propertiesSnail slimeToxicityWound healingLong before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.Veritati - Repositório Institucional da Universidade Católica PortuguesaErrajouani, FatimaBakrim, HananeHourfane, SohaibLouajri, AdnaneRocha, João MiguelEl Aouad, NoureddineLaglaoui, Amin2024-01-04T12:33:54Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/43481eng2079-928410.3390/cosmetics1006017085180499628001132030700001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-16T01:45:27Zoai:repositorio.ucp.pt:10400.14/43481Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:52.761616Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
title |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
spellingShingle |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin Errajouani, Fatima Anti-inflammatory Edema Pharmacological properties Snail slime Toxicity Wound healing |
title_short |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
title_full |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
title_fullStr |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
title_full_unstemmed |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
title_sort |
Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin |
author |
Errajouani, Fatima |
author_facet |
Errajouani, Fatima Bakrim, Hanane Hourfane, Sohaib Louajri, Adnane Rocha, João Miguel El Aouad, Noureddine Laglaoui, Amin |
author_role |
author |
author2 |
Bakrim, Hanane Hourfane, Sohaib Louajri, Adnane Rocha, João Miguel El Aouad, Noureddine Laglaoui, Amin |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Veritati - Repositório Institucional da Universidade Católica Portuguesa |
dc.contributor.author.fl_str_mv |
Errajouani, Fatima Bakrim, Hanane Hourfane, Sohaib Louajri, Adnane Rocha, João Miguel El Aouad, Noureddine Laglaoui, Amin |
dc.subject.por.fl_str_mv |
Anti-inflammatory Edema Pharmacological properties Snail slime Toxicity Wound healing |
topic |
Anti-inflammatory Edema Pharmacological properties Snail slime Toxicity Wound healing |
description |
Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12 2023-12-01T00:00:00Z 2024-01-04T12:33:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.14/43481 |
url |
http://hdl.handle.net/10400.14/43481 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2079-9284 10.3390/cosmetics10060170 85180499628 001132030700001 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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