Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin

Detalhes bibliográficos
Autor(a) principal: Errajouani, Fatima
Data de Publicação: 2023
Outros Autores: Bakrim, Hanane, Hourfane, Sohaib, Louajri, Adnane, Rocha, João Miguel, El Aouad, Noureddine, Laglaoui, Amin
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.14/43481
Resumo: Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.
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spelling Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucinAnti-inflammatoryEdemaPharmacological propertiesSnail slimeToxicityWound healingLong before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.Veritati - Repositório Institucional da Universidade Católica PortuguesaErrajouani, FatimaBakrim, HananeHourfane, SohaibLouajri, AdnaneRocha, João MiguelEl Aouad, NoureddineLaglaoui, Amin2024-01-04T12:33:54Z2023-122023-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.14/43481eng2079-928410.3390/cosmetics1006017085180499628001132030700001info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-16T01:45:27Zoai:repositorio.ucp.pt:10400.14/43481Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:30:52.761616Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
title Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
spellingShingle Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
Errajouani, Fatima
Anti-inflammatory
Edema
Pharmacological properties
Snail slime
Toxicity
Wound healing
title_short Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
title_full Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
title_fullStr Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
title_full_unstemmed Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
title_sort Exploring the potential anti-inflammatory and wound-healing proprieties of Cepaea hortensis snail mucin
author Errajouani, Fatima
author_facet Errajouani, Fatima
Bakrim, Hanane
Hourfane, Sohaib
Louajri, Adnane
Rocha, João Miguel
El Aouad, Noureddine
Laglaoui, Amin
author_role author
author2 Bakrim, Hanane
Hourfane, Sohaib
Louajri, Adnane
Rocha, João Miguel
El Aouad, Noureddine
Laglaoui, Amin
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Veritati - Repositório Institucional da Universidade Católica Portuguesa
dc.contributor.author.fl_str_mv Errajouani, Fatima
Bakrim, Hanane
Hourfane, Sohaib
Louajri, Adnane
Rocha, João Miguel
El Aouad, Noureddine
Laglaoui, Amin
dc.subject.por.fl_str_mv Anti-inflammatory
Edema
Pharmacological properties
Snail slime
Toxicity
Wound healing
topic Anti-inflammatory
Edema
Pharmacological properties
Snail slime
Toxicity
Wound healing
description Long before its popularization as a skincare ingredient, snail slime was reported to have a variety of health-promoting attributes. Its medicinal use involved the treatment of ailments, such as anthrax, hernias, stomach pain, chest pain, as well as tuberculosis. The main aim of this study was to investigate the anti-inflammatory and wound-healing properties of snail slime from Cepaea hortensis (Müller, 1774) (brown garden snail). The slime was extracted by a mild method, and the anti-inflammatory characteristics were determined by croton-oil-induced mouse-ear edema. The histological study showed that the snail slime exerts its action at the level of inflammatory mediators, explaining the drastic decrease of edema (59% in comparison to the 47% of indomethacin). The daily application of 50 µL (15 mg/kg) of snail slime on excision wounds in rabbits proved to induce an almost full tissue repair after 24 days of treatment (87.80–92.7% wound closure in width and length, respectively). Analysis of the slime’s safety aspect allowed affirming the nontoxicity of snail slime on both the skin and eyes.
publishDate 2023
dc.date.none.fl_str_mv 2023-12
2023-12-01T00:00:00Z
2024-01-04T12:33:54Z
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dc.language.iso.fl_str_mv eng
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dc.relation.none.fl_str_mv 2079-9284
10.3390/cosmetics10060170
85180499628
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