Wound healing - A literature review

Detalhes bibliográficos
Autor(a) principal: Gonzalez,Ana Cristina de Oliveira
Data de Publicação: 2016
Outros Autores: Costa,Tila Fortuna, Andrade,Zilton de Araújo, Medrado,Alena Ribeiro Alves Peixoto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Anais brasileiros de dermatologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500614
Resumo: Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
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spelling Wound healing - A literature reviewCell proliferationHedgehog proteinsInflammationWound HealingAbstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.Sociedade Brasileira de Dermatologia2016-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500614Anais Brasileiros de Dermatologia v.91 n.5 2016reponame:Anais brasileiros de dermatologia (Online)instname:Sociedade Brasileira de Dermatologia (SBD)instacron:SBD10.1590/abd1806-4841.20164741info:eu-repo/semantics/openAccessGonzalez,Ana Cristina de OliveiraCosta,Tila FortunaAndrade,Zilton de AraújoMedrado,Alena Ribeiro Alves Peixotoeng2016-11-04T00:00:00Zoai:scielo:S0365-05962016000500614Revistahttp://www.anaisdedermatologia.org.br/https://old.scielo.br/oai/scielo-oai.phpabd@sbd.org.br||revista@sbd.org.br1806-48410365-0596opendoar:2016-11-04T00:00Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)false
dc.title.none.fl_str_mv Wound healing - A literature review
title Wound healing - A literature review
spellingShingle Wound healing - A literature review
Gonzalez,Ana Cristina de Oliveira
Cell proliferation
Hedgehog proteins
Inflammation
Wound Healing
title_short Wound healing - A literature review
title_full Wound healing - A literature review
title_fullStr Wound healing - A literature review
title_full_unstemmed Wound healing - A literature review
title_sort Wound healing - A literature review
author Gonzalez,Ana Cristina de Oliveira
author_facet Gonzalez,Ana Cristina de Oliveira
Costa,Tila Fortuna
Andrade,Zilton de Araújo
Medrado,Alena Ribeiro Alves Peixoto
author_role author
author2 Costa,Tila Fortuna
Andrade,Zilton de Araújo
Medrado,Alena Ribeiro Alves Peixoto
author2_role author
author
author
dc.contributor.author.fl_str_mv Gonzalez,Ana Cristina de Oliveira
Costa,Tila Fortuna
Andrade,Zilton de Araújo
Medrado,Alena Ribeiro Alves Peixoto
dc.subject.por.fl_str_mv Cell proliferation
Hedgehog proteins
Inflammation
Wound Healing
topic Cell proliferation
Hedgehog proteins
Inflammation
Wound Healing
description Abstract: Regeneration and tissue repair processes consist of a sequence of molecular and cellular events which occur after the onset of a tissue lesion in order to restore the damaged tissue. The exsudative, proliferative, and extracellular matrix remodeling phases are sequential events that occur through the integration of dynamic processes involving soluble mediators, blood cells, and parenchymal cells. Exsudative phenomena that take place after injury contribute to the development of tissue edema. The proliferative stage seeks to reduce the area of tissue injury by contracting myofibroblasts and fibroplasia. At this stage, angiogenesis and reepithelialization processes can still be observed. Endothelial cells are able to differentiate into mesenchymal components, and this difference appears to be finely orchestrated by a set of signaling proteins that have been studied in the literature. This pathway is known as Hedgehog. The purpose of this review is to describe the various cellular and molecular aspects involved in the skin healing process.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500614
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962016000500614
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/abd1806-4841.20164741
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
publisher.none.fl_str_mv Sociedade Brasileira de Dermatologia
dc.source.none.fl_str_mv Anais Brasileiros de Dermatologia v.91 n.5 2016
reponame:Anais brasileiros de dermatologia (Online)
instname:Sociedade Brasileira de Dermatologia (SBD)
instacron:SBD
instname_str Sociedade Brasileira de Dermatologia (SBD)
instacron_str SBD
institution SBD
reponame_str Anais brasileiros de dermatologia (Online)
collection Anais brasileiros de dermatologia (Online)
repository.name.fl_str_mv Anais brasileiros de dermatologia (Online) - Sociedade Brasileira de Dermatologia (SBD)
repository.mail.fl_str_mv abd@sbd.org.br||revista@sbd.org.br
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