Immunohistochemistry for diagnosis and prognosis of breast cancer: a review

Detalhes bibliográficos
Autor(a) principal: Bonacho, T.
Data de Publicação: 2019
Outros Autores: Rodrigues, Francisco, Liberal, Joana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.11/6675
Resumo: “This is an Accepted Manuscript of an article published by Taylor & Francis in Biotechnic and Histochemistry on 10 Sep 2019, available at http://www.tandfonline.com/10.1080/10520295.2019.1651901."
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spelling Immunohistochemistry for diagnosis and prognosis of breast cancer: a reviewBreastCancerDiagnosisImmunohistochemistryPrognosisReview“This is an Accepted Manuscript of an article published by Taylor & Francis in Biotechnic and Histochemistry on 10 Sep 2019, available at http://www.tandfonline.com/10.1080/10520295.2019.1651901."Breast cancer is the most prevalent malignant tumor and main oncologic cause of mortality in women. Although most diagnosis of breast pathology is accomplished using hematoxylin and eosin stained sections, some cases require immunohistochemistry for proper evaluation. We investigated the latter cases including distinctions between ductal and lobular carcinoma, in situ and invasive carcinoma, typical ductal hyperplasia and atypical ductal hyperplasia/ductal carcinoma in situ, papillary and spindle cell lesion assessment, metastasis evaluation, and assessment of prognostic and therapy markers. E-cadherin is used to differentiate ductal and lobular carcinoma; 34βE12, CK8, p120 catenin and β-catenin also produce consistent results. Myoepithelial cell (MEC) stains are used to evaluate in situ and invasive carcinoma; calponin, smooth muscle myosin heavy chain and p63 are sensitive/specific markers. 34βE12 and CK5/6 are positive in ductal hyperplasia, which enables its differentiation from atypical ductal hyperplasia and ductal carcinoma in situ. CK 5/6, ER and MEC markers are consistent options for evaluating papillary lesions. Spindle cell lesions can be assessed using β-catenin, SMA, CD34, p63, CKs and hormone receptors. It is important to differentiate primary carcinomas from metastases; the most commonly used markers to identify breast origin include mammaglobin, GCDFP-15, GATA3 and ER, although none of these is completely sensitive or specific. Immunohistochemistry can be used to evaluate central prognostic and predictive factors including molecular subtypes, HER2, hormone receptors, proliferation markers (Ki-67) and lymph-vascular invasion markers including ERG, CD31, CD34, factor VIII and podoplanin. Owing to the complexity of mammary lesions, diagnosis also depends on each particular situation, evaluation of cytological characteristics revealed by immunochemistry and correlation with histological findings.Repositório Científico do Instituto Politécnico de Castelo BrancoBonacho, T.Rodrigues, FranciscoLiberal, Joana2020-12-31T01:30:22Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.11/6675engBONACHO, T. ; Rodrigues, F.; Liberal, J. (2019) - Immunohistochemistry for diagnosis and prognosis of breast cancer: a review. Biotechnic and Histochemistry. ISSN 1473-7760. DOI: 10.1080/10520295.2019.16519011052-0295 (Print)10.1080/10520295.2019.1651901info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-01-16T11:46:49Zoai:repositorio.ipcb.pt:10400.11/6675Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:37:21.830758Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
title Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
spellingShingle Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
Bonacho, T.
Breast
Cancer
Diagnosis
Immunohistochemistry
Prognosis
Review
title_short Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
title_full Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
title_fullStr Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
title_full_unstemmed Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
title_sort Immunohistochemistry for diagnosis and prognosis of breast cancer: a review
author Bonacho, T.
author_facet Bonacho, T.
Rodrigues, Francisco
Liberal, Joana
author_role author
author2 Rodrigues, Francisco
Liberal, Joana
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico de Castelo Branco
dc.contributor.author.fl_str_mv Bonacho, T.
Rodrigues, Francisco
Liberal, Joana
dc.subject.por.fl_str_mv Breast
Cancer
Diagnosis
Immunohistochemistry
Prognosis
Review
topic Breast
Cancer
Diagnosis
Immunohistochemistry
Prognosis
Review
description “This is an Accepted Manuscript of an article published by Taylor & Francis in Biotechnic and Histochemistry on 10 Sep 2019, available at http://www.tandfonline.com/10.1080/10520295.2019.1651901."
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2020-12-31T01:30:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.11/6675
url http://hdl.handle.net/10400.11/6675
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv BONACHO, T. ; Rodrigues, F.; Liberal, J. (2019) - Immunohistochemistry for diagnosis and prognosis of breast cancer: a review. Biotechnic and Histochemistry. ISSN 1473-7760. DOI: 10.1080/10520295.2019.1651901
1052-0295 (Print)
10.1080/10520295.2019.1651901
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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