Study of p53 codon 72 polymorphism in patients with breast cancer
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://www.irog.net/download/?magazine=80 http://repositorio.unifesp.br/handle/11600/43597 |
Resumo: | Breast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer. |
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Repositório Institucional da UNIFESP |
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Study of p53 codon 72 polymorphism in patients with breast cancerp53 polymorphismbreast cancerprognosisBreast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer.Univ Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilWeb of ScienceI R O G Canada, IncUniversidade Federal de São Paulo (UNIFESP)Vieira, J. O.Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]Higo, P. E. S.Nogueira-de-Souza, Naiara Corrêa [UNIFESP]Gebrim, Luiz Henrique [UNIFESP]2018-06-15T17:22:25Z2018-06-15T17:22:25Z2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion364-367http://www.irog.net/download/?magazine=80European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008.0392-2936http://repositorio.unifesp.br/handle/11600/43597WOS:000257220000011engEuropean Journal Of Gynaecological Oncologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:56:07Zoai:repositorio.unifesp.br/:11600/43597Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:56:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Study of p53 codon 72 polymorphism in patients with breast cancer |
title |
Study of p53 codon 72 polymorphism in patients with breast cancer |
spellingShingle |
Study of p53 codon 72 polymorphism in patients with breast cancer Vieira, J. O. p53 polymorphism breast cancer prognosis |
title_short |
Study of p53 codon 72 polymorphism in patients with breast cancer |
title_full |
Study of p53 codon 72 polymorphism in patients with breast cancer |
title_fullStr |
Study of p53 codon 72 polymorphism in patients with breast cancer |
title_full_unstemmed |
Study of p53 codon 72 polymorphism in patients with breast cancer |
title_sort |
Study of p53 codon 72 polymorphism in patients with breast cancer |
author |
Vieira, J. O. |
author_facet |
Vieira, J. O. Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] Higo, P. E. S. Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Gebrim, Luiz Henrique [UNIFESP] |
author_role |
author |
author2 |
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] Higo, P. E. S. Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Gebrim, Luiz Henrique [UNIFESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Vieira, J. O. Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP] Higo, P. E. S. Nogueira-de-Souza, Naiara Corrêa [UNIFESP] Gebrim, Luiz Henrique [UNIFESP] |
dc.subject.por.fl_str_mv |
p53 polymorphism breast cancer prognosis |
topic |
p53 polymorphism breast cancer prognosis |
description |
Breast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-01-01 2018-06-15T17:22:25Z 2018-06-15T17:22:25Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.irog.net/download/?magazine=80 European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008. 0392-2936 http://repositorio.unifesp.br/handle/11600/43597 WOS:000257220000011 |
url |
http://www.irog.net/download/?magazine=80 http://repositorio.unifesp.br/handle/11600/43597 |
identifier_str_mv |
European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008. 0392-2936 WOS:000257220000011 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal Of Gynaecological Oncology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
364-367 |
dc.publisher.none.fl_str_mv |
I R O G Canada, Inc |
publisher.none.fl_str_mv |
I R O G Canada, Inc |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268331181473792 |