Study of p53 codon 72 polymorphism in patients with breast cancer

Detalhes bibliográficos
Autor(a) principal: Vieira, J. O.
Data de Publicação: 2008
Outros Autores: Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP], Higo, P. E. S., Nogueira-de-Souza, Naiara Corrêa [UNIFESP], Gebrim, Luiz Henrique [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://www.irog.net/download/?magazine=80
http://repositorio.unifesp.br/handle/11600/43597
Resumo: Breast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer.
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spelling Study of p53 codon 72 polymorphism in patients with breast cancerp53 polymorphismbreast cancerprognosisBreast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer.Univ Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Gynecol, Mol Gynecol Lab, BR-04039032 Sao Paulo, BrazilWeb of ScienceI R O G Canada, IncUniversidade Federal de São Paulo (UNIFESP)Vieira, J. O.Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]Higo, P. E. S.Nogueira-de-Souza, Naiara Corrêa [UNIFESP]Gebrim, Luiz Henrique [UNIFESP]2018-06-15T17:22:25Z2018-06-15T17:22:25Z2008-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion364-367http://www.irog.net/download/?magazine=80European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008.0392-2936http://repositorio.unifesp.br/handle/11600/43597WOS:000257220000011engEuropean Journal Of Gynaecological Oncologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-05-02T13:56:07Zoai:repositorio.unifesp.br/:11600/43597Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-05-02T13:56:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Study of p53 codon 72 polymorphism in patients with breast cancer
title Study of p53 codon 72 polymorphism in patients with breast cancer
spellingShingle Study of p53 codon 72 polymorphism in patients with breast cancer
Vieira, J. O.
p53 polymorphism
breast cancer
prognosis
title_short Study of p53 codon 72 polymorphism in patients with breast cancer
title_full Study of p53 codon 72 polymorphism in patients with breast cancer
title_fullStr Study of p53 codon 72 polymorphism in patients with breast cancer
title_full_unstemmed Study of p53 codon 72 polymorphism in patients with breast cancer
title_sort Study of p53 codon 72 polymorphism in patients with breast cancer
author Vieira, J. O.
author_facet Vieira, J. O.
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Higo, P. E. S.
Nogueira-de-Souza, Naiara Corrêa [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
author_role author
author2 Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Higo, P. E. S.
Nogueira-de-Souza, Naiara Corrêa [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Vieira, J. O.
Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]
Higo, P. E. S.
Nogueira-de-Souza, Naiara Corrêa [UNIFESP]
Gebrim, Luiz Henrique [UNIFESP]
dc.subject.por.fl_str_mv p53 polymorphism
breast cancer
prognosis
topic p53 polymorphism
breast cancer
prognosis
description Breast cancer is a common disease in Western societies, with an incidence of 46.3 1/100,000 women/year in Brazil. The tumor suppressor gene TP53 is one of the most studied genes regarding the presence of mutations. Indeed, 50% of all tumors are known to exhibit changes in the TP53 nucleotide sequence due to carcinogenic processes. As to the presence of polymorphism, the TP53 gene is polymorphic at the nucleotide residue 347 (codon 72).In the current study, we examine if this polymorphism is associated with the clinicopathological parameters of breast cancer patients in a Brazilian population. One hundred and thirteen patients with breast cancer were included. The polymorphic region of the TP53 gene was PCR-amplified from genomic DNA obtained from buccal cells. Specific primers for the Pro and Arg allele were used.Correlations of polymorphism with age, staging, nuclear grade, lymph node status, estrogen receptor status and lymphatic and/or blood vessel invasion were evaluated. Statistical analysis was performed using the Fisher's exact test The frequency of p53 Arg/Arg was 57% and of the heterozygous allele Arg/Pro it was 39%.There was no correlation between polymorphism and clinicopathological parameters. According to our results, the TP53 polymorphism, at the 347 residue, is not associated with any clinicopathological findings of patients with breast cancer.
publishDate 2008
dc.date.none.fl_str_mv 2008-01-01
2018-06-15T17:22:25Z
2018-06-15T17:22:25Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.irog.net/download/?magazine=80
European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008.
0392-2936
http://repositorio.unifesp.br/handle/11600/43597
WOS:000257220000011
url http://www.irog.net/download/?magazine=80
http://repositorio.unifesp.br/handle/11600/43597
identifier_str_mv European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 29, n. 4, p. 364-367, 2008.
0392-2936
WOS:000257220000011
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv European Journal Of Gynaecological Oncology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 364-367
dc.publisher.none.fl_str_mv I R O G Canada, Inc
publisher.none.fl_str_mv I R O G Canada, Inc
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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