Nanoparticles for bone tissue engineering

Detalhes bibliográficos
Autor(a) principal: Vieira, Sílvia
Data de Publicação: 2017
Outros Autores: Vial, Stephanie, Reis, R. L., Oliveira, J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/47015
Resumo: Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone. Therefore, nanoengineered systems are now able to more closely mimic the structures observed in naturally occurring systems, and it is also possible to combine several approaches - such as drug delivery and cell labeling - within a single system. This review aims to cover the most recent developments on the use of different nanoparticles for bone TE, with emphasis on their application for scaffolds improvement; drug and gene delivery carriers, and labeling techniques.
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spelling Nanoparticles for bone tissue engineeringBone Tissue EngineeringDrug and Gene DeliveryImagingNanoparticlesScaffoldsTissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone. Therefore, nanoengineered systems are now able to more closely mimic the structures observed in naturally occurring systems, and it is also possible to combine several approaches - such as drug delivery and cell labeling - within a single system. This review aims to cover the most recent developments on the use of different nanoparticles for bone TE, with emphasis on their application for scaffolds improvement; drug and gene delivery carriers, and labeling techniques.This study was funded by QREN (ON.2 - NORTE-01-0124-FEDER-000018), as well as the European Union’s FP7 Programme under grant agreement number REGPOTCT2012-316331-POLARIS. Sılvia Vieira was awarded an FCT PhD scholarship (SFRH/BD/102710/2014). The FCT distinction attributed to J.M.O. under the Investigator FCT program (IF/00423/2012 and IF/01285/2015) is also greatly acknowledged.info:eu-repo/semantics/publishedVersionAmerican Institute of Chemical EngineersUniversidade do MinhoVieira, SílviaVial, StephanieReis, R. L.Oliveira, J. M.2017-042017-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/47015engVieira S., Vial S., Reis R. L., Oliveira J. M. Nanoparticles for Bone Tissue Engineering., Biotechnology Progress, doi:10.1002/btpr.2469, 20178756-79381520-603310.1002/btpr.246928371447http://onlinelibrary.wiley.com/doi/10.1002/btpr.2469/fullinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:40:42Zoai:repositorium.sdum.uminho.pt:1822/47015Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:37:33.537898Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanoparticles for bone tissue engineering
title Nanoparticles for bone tissue engineering
spellingShingle Nanoparticles for bone tissue engineering
Vieira, Sílvia
Bone Tissue Engineering
Drug and Gene Delivery
Imaging
Nanoparticles
Scaffolds
title_short Nanoparticles for bone tissue engineering
title_full Nanoparticles for bone tissue engineering
title_fullStr Nanoparticles for bone tissue engineering
title_full_unstemmed Nanoparticles for bone tissue engineering
title_sort Nanoparticles for bone tissue engineering
author Vieira, Sílvia
author_facet Vieira, Sílvia
Vial, Stephanie
Reis, R. L.
Oliveira, J. M.
author_role author
author2 Vial, Stephanie
Reis, R. L.
Oliveira, J. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Vieira, Sílvia
Vial, Stephanie
Reis, R. L.
Oliveira, J. M.
dc.subject.por.fl_str_mv Bone Tissue Engineering
Drug and Gene Delivery
Imaging
Nanoparticles
Scaffolds
topic Bone Tissue Engineering
Drug and Gene Delivery
Imaging
Nanoparticles
Scaffolds
description Tissue engineering (TE) envisions the creation of functional substitutes for damaged tissues through integrated solutions, where medical, biological, and engineering principles are combined. Bone regeneration is one of the areas in which designing a model that mimics all tissue properties is still a challenge. The hierarchical structure and high vascularization of bone hampers a TE approach, especially in large bone defects. Nanotechnology can open up a new era for TE, allowing the creation of nanostructures that are comparable in size to those appearing in natural bone. Therefore, nanoengineered systems are now able to more closely mimic the structures observed in naturally occurring systems, and it is also possible to combine several approaches - such as drug delivery and cell labeling - within a single system. This review aims to cover the most recent developments on the use of different nanoparticles for bone TE, with emphasis on their application for scaffolds improvement; drug and gene delivery carriers, and labeling techniques.
publishDate 2017
dc.date.none.fl_str_mv 2017-04
2017-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/47015
url http://hdl.handle.net/1822/47015
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Vieira S., Vial S., Reis R. L., Oliveira J. M. Nanoparticles for Bone Tissue Engineering., Biotechnology Progress, doi:10.1002/btpr.2469, 2017
8756-7938
1520-6033
10.1002/btpr.2469
28371447
http://onlinelibrary.wiley.com/doi/10.1002/btpr.2469/full
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv American Institute of Chemical Engineers
publisher.none.fl_str_mv American Institute of Chemical Engineers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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