Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1

Detalhes bibliográficos
Autor(a) principal: Sousa, João Dinis
Data de Publicação: 2021
Outros Autores: Havik, Philip J., Müller, Viktor, Vandamme, Anne Mieke
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/125100
Resumo: Funding Information: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek?Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.?s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Funding Information: Funding: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek—Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.’s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1Central AfricaEnhanced heterosexual transmission hypothesisHIVHIV-1Origin of HIVPandemicsSexually transmitted diseasesZoonosisInfectious DiseasesVirologySDG 3 - Good Health and Well-beingFunding Information: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek?Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.?s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Funding Information: Funding: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek—Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.’s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.To which extent STDs facilitated HIV-1 adaptation to humans, sparking the pandemic, is still unknown. We searched colonial medical records from 1906–1958 for Leopoldville, Belgian Congo, which was the initial epicenter of pandemic HIV-1, compiling counts of treated STD cases in both Africans and Europeans. Almost all Europeans were being treated, while for Africans, generalized treatment started only in 1929. Treated STD counts in Europeans thus reflect STD infection rates more accurately compared to counts in Africans. In Africans, the highest recorded STD treatment incidence was in 1929–1935, declining to low levels in the 1950s. In Europeans, the recorded treatment incidences were highest during the period 1910–1920, far exceeding those in Africans. Europeans were overwhelmingly male and had frequent sexual contact with African females. Consequently, high STD incidence among Europeans must have coincided with high prevalence and incidence in the city’s African population. The data strongly suggest the worst STD period was 1910–1920 for both Africans and Europeans, which coincides with the estimated origin of pandemic HIV-1. Given the strong effect of STD coinfections on HIV transmission, these new data support our hypothesis of a causal effect of STDs on the epidemic emergence of HIV-1.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Individual Health Care (IHC)TB, HIV and opportunistic diseases and pathogens (THOP)RUNSousa, João DinisHavik, Philip J.Müller, ViktorVandamme, Anne Mieke2021-09-24T02:25:11Z2021-092021-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/125100eng1999-4915PURE: 33794923https://doi.org/10.3390/v13091701info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:06:18Zoai:run.unl.pt:10362/125100Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:45:40.063561Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
title Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
spellingShingle Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
Sousa, João Dinis
Central Africa
Enhanced heterosexual transmission hypothesis
HIV
HIV-1
Origin of HIV
Pandemics
Sexually transmitted diseases
Zoonosis
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
title_short Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
title_full Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
title_fullStr Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
title_full_unstemmed Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
title_sort Newly discovered archival data show coincidence of a peak of sexually transmitted diseases with the early epicenter of pandemic hiv-1
author Sousa, João Dinis
author_facet Sousa, João Dinis
Havik, Philip J.
Müller, Viktor
Vandamme, Anne Mieke
author_role author
author2 Havik, Philip J.
Müller, Viktor
Vandamme, Anne Mieke
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
Individual Health Care (IHC)
TB, HIV and opportunistic diseases and pathogens (THOP)
RUN
dc.contributor.author.fl_str_mv Sousa, João Dinis
Havik, Philip J.
Müller, Viktor
Vandamme, Anne Mieke
dc.subject.por.fl_str_mv Central Africa
Enhanced heterosexual transmission hypothesis
HIV
HIV-1
Origin of HIV
Pandemics
Sexually transmitted diseases
Zoonosis
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
topic Central Africa
Enhanced heterosexual transmission hypothesis
HIV
HIV-1
Origin of HIV
Pandemics
Sexually transmitted diseases
Zoonosis
Infectious Diseases
Virology
SDG 3 - Good Health and Well-being
description Funding Information: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek?Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.?s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Funding Information: Funding: The research done by J.D.S. and A.-M.V. in this study has been supported in part by grant G.0692.14, funded by the Fonds voor Wetenschappelijk Onderzoek—Flanders (FWO, http://www.fwo.be/en/ (accessed on 28 July 2021)), Belgium. V.M.’s work in this study has been completed as part of the ELTE Thematic Excellence Programme 2020 supported by the National Research, Development and Innovation Office (TKP2020-IKA-05). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-24T02:25:11Z
2021-09
2021-09-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/125100
url http://hdl.handle.net/10362/125100
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4915
PURE: 33794923
https://doi.org/10.3390/v13091701
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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