Rheumatoid arthritis: extra-articular manifestations, immunology and the role of methotrexate

• Autor(a) principal: Tribolet de Abreu, Tiago
• Data de Publicação: 2000
• Outros Autores: Panarra, António, Ferreira, Ana, Soromenho, Francisco, Vaz Riscado, Manuel
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/1995
• topic: artrite reumatóide; manifestações extra-articulares; síndroma de Sjõgren; imunologia; metotrexato; rheumatoid arthritis; extra-articular manifestations; Sjõgren's syndrome; immunology; methotrexate

Objective: To determine the extraarticular manifestations, immunology and the role of methotrexate use in a population of 67 patients with rheumatoid arthritis. Methods: The clinical charts from all the patients in our Unit with the diagnosis of Rheumatoid Arthritis were reviewed. Results and conclusions: 83,6% of the patients were female, with a mean age of 59,5 years. The most prevalent extraarticular manifestations were anaemia (35,8%), liver cell enzyme abnormalities (26,9%) and pulmonary fibrosis (17,9%). Sjogren's syndrome (16,4%), antiphospholipid syndrome (3%) and morphea (3%) were associated autoimune diseases. Patients were positive for rheumatoid factor in 80,3%, for antinuclear antibodies in 26,9% and for antiphospholipid antibodies in 39,1%. Methotrexate was used in 71,4%, and was stopped in 6,3% for Jack of clinical response and in 7,9% because of toxicity.