Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Henrique G.
Data de Publicação: 2022
Outros Autores: Nilsson, Anna, Melo, Luís Daniel Rodrigues, Oliveira, Ana C. A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/1822/78986
Resumo: The Supplementary materials for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2022.903861/full#supplementary-material
id RCAP_5f28b1a6acc73dbbfba020d959b55948
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/78986
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for beesPaenibacillus larvaeprophagebacterial evolutionbacterial fitnessbacterial virulenceScience & TechnologyThe Supplementary materials for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2022.903861/full#supplementary-materialPaenibacillus larvae is the etiological agent of American Foulbrood (AFB), a highly contagious and worldwide spread bacterial disease that affects honeybee brood. In this study, all complete P. larvae genomes available on the NCBI database were analyzed in order to detect presence of prophages using the PHASTER software. A total of 55 intact prophages were identified in 11 P. larvae genomes (5.0±2.3 per genome) and were further investigated for the presence of genes encoding relevant traits related to P. larvae. A closer look at the prophage genomes revealed the presence of several putative genes such as metabolic and antimicrobial resistance genes, toxins or bacteriocins, potentially influencing host performance. Some of the coding DNA sequences (CDS) were present in all ERIC-genotypes, while others were only found in a specific genotype. While CDS encoding toxins and antitoxins such as HicB and MazE were found in prophages of all bacterial genotypes, others, from the same category, were provided by prophages particularly to ERIC I (enhancin-like toxin), ERIC II (antitoxin SocA) and ERIC V strains (subunit of Panton-Valentine leukocidin system (PVL) LukF-PV). This is the first in-depth analysis of P. larvae prophages. It provides better knowledge on their impact in the evolution of virulence and fitness of P. larvae, by discovering new features assigned by the viruses.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit. HR was supported by FCT through the grant SFRH/BD/128859/2017 and COVID/BD/151856/2021.info:eu-repo/semantics/publishedVersionFrontiers Media S.A.Universidade do MinhoRibeiro, Henrique G.Nilsson, AnnaMelo, Luís Daniel RodriguesOliveira, Ana C. A.2022-07-152022-07-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/1822/78986engRibeiro, Henrique G.; Nilsson, Anna; Melo, Luís Daniel Rodrigues; Oliveira, Ana C. A., Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees. Frontiers in Microbiology, 13(903861), 20221664-302X10.3389/fmicb.2022.903861http://journal.frontiersin.org/journal/microbiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:20Zoai:repositorium.sdum.uminho.pt:1822/78986Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:50.522141Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
title Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
spellingShingle Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
Ribeiro, Henrique G.
Paenibacillus larvae
prophage
bacterial evolution
bacterial fitness
bacterial virulence
Science & Technology
title_short Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
title_full Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
title_fullStr Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
title_full_unstemmed Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
title_sort Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees
author Ribeiro, Henrique G.
author_facet Ribeiro, Henrique G.
Nilsson, Anna
Melo, Luís Daniel Rodrigues
Oliveira, Ana C. A.
author_role author
author2 Nilsson, Anna
Melo, Luís Daniel Rodrigues
Oliveira, Ana C. A.
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Ribeiro, Henrique G.
Nilsson, Anna
Melo, Luís Daniel Rodrigues
Oliveira, Ana C. A.
dc.subject.por.fl_str_mv Paenibacillus larvae
prophage
bacterial evolution
bacterial fitness
bacterial virulence
Science & Technology
topic Paenibacillus larvae
prophage
bacterial evolution
bacterial fitness
bacterial virulence
Science & Technology
description The Supplementary materials for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmicb.2022.903861/full#supplementary-material
publishDate 2022
dc.date.none.fl_str_mv 2022-07-15
2022-07-15T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/1822/78986
url https://hdl.handle.net/1822/78986
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Ribeiro, Henrique G.; Nilsson, Anna; Melo, Luís Daniel Rodrigues; Oliveira, Ana C. A., Analysis of intact prophages in genomes of Paenibacillus larvae: An important pathogen for bees. Frontiers in Microbiology, 13(903861), 2022
1664-302X
10.3389/fmicb.2022.903861
http://journal.frontiersin.org/journal/microbiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799132785653317632

Registros relacionados