The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging

Detalhes bibliográficos
Autor(a) principal: Francisco, Stephany
Data de Publicação: 2022
Outros Autores: Martinho, Vera, Ferreira, Margarida, Reis, Andreia, Moura, Gabriela, Soares, Ana Raquel, Santos Manuel A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10773/34660
Resumo: Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.
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spelling The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle agingAge-related protein aggregationMammalian tissue agingMiRNAProteostasis networkAging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.MDPI2022-09-20T09:03:05Z2022-03-17T00:00:00Z2022-03-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/34660eng1661-659610.3390/ijms23063232Francisco, StephanyMartinho, VeraFerreira, MargaridaReis, AndreiaMoura, GabrielaSoares, Ana RaquelSantos Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:06:34Zoai:ria.ua.pt:10773/34660Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:05:47.249594Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
title The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
spellingShingle The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
Francisco, Stephany
Age-related protein aggregation
Mammalian tissue aging
MiRNA
Proteostasis network
title_short The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
title_full The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
title_fullStr The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
title_full_unstemmed The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
title_sort The role of MicroRNAs in proteostasis decline and protein aggregation during brain and skeletal muscle aging
author Francisco, Stephany
author_facet Francisco, Stephany
Martinho, Vera
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos Manuel A. S.
author_role author
author2 Martinho, Vera
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos Manuel A. S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Francisco, Stephany
Martinho, Vera
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos Manuel A. S.
dc.subject.por.fl_str_mv Age-related protein aggregation
Mammalian tissue aging
MiRNA
Proteostasis network
topic Age-related protein aggregation
Mammalian tissue aging
MiRNA
Proteostasis network
description Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.
publishDate 2022
dc.date.none.fl_str_mv 2022-09-20T09:03:05Z
2022-03-17T00:00:00Z
2022-03-17
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10773/34660
url http://hdl.handle.net/10773/34660
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1661-6596
10.3390/ijms23063232
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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