The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging

Detalhes bibliográficos
Autor(a) principal: Francisco, Stephany
Data de Publicação: 2022
Outros Autores: Martinho, Vera C., Ferreira, Margarida, Reis, Andreia, Moura, Gabriela, Soares, Ana Raquel, Santos, Manuel A. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/103322
https://doi.org/10.3390/ijms23063232
Resumo: Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.
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spelling The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle AgingmiRNAmammalian tissue agingage-related protein aggregationproteostasis networkBrainMuscle, SkeletalProtein AggregatesMicroRNAsProteostasisAging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.This research was funded by the PORTUGUESE FOUNDATION FOR SCIENCE AND TECHNOLOGY (FCT) and FEDER (FUNDO EUROPEU DE DESENVOLVIMENTO REGIONAL) through the COMPETE 2020, OPERATIONAL PROGRAMME FOR COMPETITIVENESS AND INTERNATIONALIZATION (POCI) (GenomePT: POCI-01-0145-FEDER-022184;WISDOM: POCI-01-0145-FEDER-029843); MEDISIS (CENTRO-01-0246-FEDER-000018); and project “Piloto para a elaboração de uma estratégia e uma rede regional para a medicina personalizada/precisão” Grant (CENTRO-08-5864-FSE-000039). The iBiMED research unit is supported by FCT (UID/BIM/04501/2020). S.F. and M.F. are directly supported by FCT grants (SFRH/BD/148323/2019 and SFRH/BD/131736/2017). A.R.S. is supported by an individual CEEC auxiliary research contract (CEECIND/00284/2018).2022-03-17info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103322http://hdl.handle.net/10316/103322https://doi.org/10.3390/ijms23063232eng1422-0067Francisco, StephanyMartinho, Vera C.Ferreira, MargaridaReis, AndreiaMoura, GabrielaSoares, Ana RaquelSantos, Manuel A. S.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-06T10:20:07Zoai:estudogeral.uc.pt:10316/103322Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:10.729661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
title The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
spellingShingle The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
Francisco, Stephany
miRNA
mammalian tissue aging
age-related protein aggregation
proteostasis network
Brain
Muscle, Skeletal
Protein Aggregates
MicroRNAs
Proteostasis
title_short The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
title_full The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
title_fullStr The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
title_full_unstemmed The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
title_sort The Role of MicroRNAs in Proteostasis Decline and Protein Aggregation during Brain and Skeletal Muscle Aging
author Francisco, Stephany
author_facet Francisco, Stephany
Martinho, Vera C.
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos, Manuel A. S.
author_role author
author2 Martinho, Vera C.
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos, Manuel A. S.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Francisco, Stephany
Martinho, Vera C.
Ferreira, Margarida
Reis, Andreia
Moura, Gabriela
Soares, Ana Raquel
Santos, Manuel A. S.
dc.subject.por.fl_str_mv miRNA
mammalian tissue aging
age-related protein aggregation
proteostasis network
Brain
Muscle, Skeletal
Protein Aggregates
MicroRNAs
Proteostasis
topic miRNA
mammalian tissue aging
age-related protein aggregation
proteostasis network
Brain
Muscle, Skeletal
Protein Aggregates
MicroRNAs
Proteostasis
description Aging can be defined as the progressive deterioration of cellular, tissue, and organismal function over time. Alterations in protein homeostasis, also known as proteostasis, are a hallmark of aging that lead to proteome imbalances and protein aggregation, phenomena that also occur in age-related diseases. Among the various proteostasis regulators, microRNAs (miRNAs) have been reported to play important roles in the post-transcriptional control of genes involved in maintaining proteostasis during the lifespan in several organismal tissues. In this review, we consolidate recently published reports that demonstrate how miRNAs regulate fundamental proteostasis-related processes relevant to tissue aging, with emphasis on the two most studied tissues, brain tissue and skeletal muscle. We also explore an emerging perspective on the role of miRNA regulatory networks in age-related protein aggregation, a known hallmark of aging and age-related diseases, to elucidate potential miRNA candidates for anti-aging diagnostic and therapeutic targets.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-17
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/103322
http://hdl.handle.net/10316/103322
https://doi.org/10.3390/ijms23063232
url http://hdl.handle.net/10316/103322
https://doi.org/10.3390/ijms23063232
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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