Magnetogels: prospects and main challenges in biomedical applications

Detalhes bibliográficos
Autor(a) principal: Veloso, Sérgio Rafael Silva
Data de Publicação: 2018
Outros Autores: Ferreira, Paula M. T., Martins, J. A. R., Coutinho, Paulo J. G., Castanheira, Elisabete M. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/55949
Resumo: Drug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives.
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spelling Magnetogels: prospects and main challenges in biomedical applicationsMagnetic nanoparticlesHydrogelsCancer therapyMagnetic hyperthermiadrug deliverybiomedical applicationsEngenharia e Tecnologia::NanotecnologiaScience & TechnologyDrug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives.This work was funded by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013) and CQUM (UID/QUI/00686/2016). S.R.S.V. acknowledges FCT for a research grant under UID/FIS/04650/2013 funding.info:eu-repo/semantics/publishedVersionMDPIUniversidade do MinhoVeloso, Sérgio Rafael SilvaFerreira, Paula M. T.Martins, J. A. R.Coutinho, Paulo J. G.Castanheira, Elisabete M. S.20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/55949engPharmaceutics 2018, 10(3), 1451999-492310.3390/pharmaceutics10030145http://www.mdpi.com/1999-4923/10/3/145info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T11:57:34Zoai:repositorium.sdum.uminho.pt:1822/55949Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:47:13.901661Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Magnetogels: prospects and main challenges in biomedical applications
title Magnetogels: prospects and main challenges in biomedical applications
spellingShingle Magnetogels: prospects and main challenges in biomedical applications
Veloso, Sérgio Rafael Silva
Magnetic nanoparticles
Hydrogels
Cancer therapy
Magnetic hyperthermia
drug delivery
biomedical applications
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
title_short Magnetogels: prospects and main challenges in biomedical applications
title_full Magnetogels: prospects and main challenges in biomedical applications
title_fullStr Magnetogels: prospects and main challenges in biomedical applications
title_full_unstemmed Magnetogels: prospects and main challenges in biomedical applications
title_sort Magnetogels: prospects and main challenges in biomedical applications
author Veloso, Sérgio Rafael Silva
author_facet Veloso, Sérgio Rafael Silva
Ferreira, Paula M. T.
Martins, J. A. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
author_role author
author2 Ferreira, Paula M. T.
Martins, J. A. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Veloso, Sérgio Rafael Silva
Ferreira, Paula M. T.
Martins, J. A. R.
Coutinho, Paulo J. G.
Castanheira, Elisabete M. S.
dc.subject.por.fl_str_mv Magnetic nanoparticles
Hydrogels
Cancer therapy
Magnetic hyperthermia
drug delivery
biomedical applications
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
topic Magnetic nanoparticles
Hydrogels
Cancer therapy
Magnetic hyperthermia
drug delivery
biomedical applications
Engenharia e Tecnologia::Nanotecnologia
Science & Technology
description Drug delivery nanosystems have been thriving in recent years as a promising application in therapeutics, seeking to solve the lack of specificity of conventional chemotherapy targeting and add further features such as enhanced magnetic resonance imaging, biosensing and hyperthermia. The combination of magnetic nanoparticles and hydrogels introduces a new generation of nanosystems, the magnetogels, which combine the advantages of both nanomaterials, apart from showing interesting properties unobtainable when both systems are separated. The presence of magnetic nanoparticles allows the control and targeting of the nanosystem to a specific location by an externally applied magnetic field gradient. Moreover, the application of an alternating magnetic field (AMF) not only allows therapy through hyperthermia, but also enhances drug delivery and chemotherapeutic desired effects, which combined with the hydrogel specificity, confer a high therapeutic efficiency. Therefore, the present review summarizes the magnetogels properties and critically discusses their current and recent biomedical applications, apart from an outlook on future goals and perspectives.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/55949
url http://hdl.handle.net/1822/55949
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pharmaceutics 2018, 10(3), 145
1999-4923
10.3390/pharmaceutics10030145
http://www.mdpi.com/1999-4923/10/3/145
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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