Impact of citrate and lipid-functionalized magnetic nanoparticles in dehydropeptide supramolecular magnetogels: properties, design and drug release

• Autor(a) principal: Veloso, Sérgio R S
• Data de Publicação: 2021
• Outros Autores: Silva, Joana F G, Hilliou, L., Moura, Cacilda, Coutinho, Paulo J. G., Martins, J. A. R., Testa-Anta, Martín, Salgueiriño, Verónica, Correa-Duarte, Miguel A, Ferreira, Paula M. T., Castanheira, Elisabete M. S.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/1822/69202
• topic: magnetic nanoparticles; magnetogels; drug delivery; magnetic gels; drug release; magnetic hyperthermia; magnetic lipogels; supramolecular hydrogels; self-assembly; nanoparticle functionalization; Engenharia e Tecnologia::Nanotecnologia; Science & Technology; Saúde de qualidade

Currently, the nanoparticle functionalization effect on supramolecular peptide-based hydrogels remains undescribed, but is expected to affect the hydrogels' self-assembly and final magnetic gel properties. Herein, two different functionalized nanoparticles: citrate-stabilized (14.4 ± 2.6 nm) and lipid-coated (8.9 ± 2.1 nm) magnetic nanoparticles, were used for the formation of dehydropeptide-based supramolecular magnetogels consisting of the ultra-short hydrogelator Cbz-L-Met-Z-ΔPhe-OH, with an assessment of their effect over gel properties. The lipid-coated nanoparticles were distributed along the hydrogel fibers, while citrate-stabilized nanoparticles were aggregated upon gelation, which resulted into a heating efficiency improvement and decrease, respectively. Further, the lipid-coated nanoparticles did not affect drug encapsulation and displayed improved drug release reproducibility compared to citrate-stabilized nanoparticles, despite the latter attaining a stronger AMF-trigger. This report points out that adsorption of nanoparticles to hydrogel fibers, which display domains that improve or do not affect drug encapsulation, can be explored as a means to optimize the development of supramolecular magnetogels to advance theranostic applications.