Beyond multidrug-resistant tuberculosis in Europe: a TBNET study

Detalhes bibliográficos
Autor(a) principal: Günther, G
Data de Publicação: 2015
Outros Autores: van Leth, F, Altet, N, Dedicoat, M, Duarte, R, Gualano, G, Kunst, H, Muylle, I, Spinu, V, Tiberi, S, Viiklepp, P, Lange, C
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10216/114669
Resumo: The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).
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spelling Beyond multidrug-resistant tuberculosis in Europe: a TBNET studyMultidrug-resistant tuberculosisThe emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10216/114669eng1027-371910.5588/ijtld.15.0274Günther, Gvan Leth, FAltet, NDedicoat, MDuarte, RGualano, GKunst, HMuylle, ISpinu, VTiberi, SViiklepp, PLange, Cinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:54:47Zoai:repositorio-aberto.up.pt:10216/114669Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:35:12.065380Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
title Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
spellingShingle Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
Günther, G
Multidrug-resistant tuberculosis
title_short Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
title_full Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
title_fullStr Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
title_full_unstemmed Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
title_sort Beyond multidrug-resistant tuberculosis in Europe: a TBNET study
author Günther, G
author_facet Günther, G
van Leth, F
Altet, N
Dedicoat, M
Duarte, R
Gualano, G
Kunst, H
Muylle, I
Spinu, V
Tiberi, S
Viiklepp, P
Lange, C
author_role author
author2 van Leth, F
Altet, N
Dedicoat, M
Duarte, R
Gualano, G
Kunst, H
Muylle, I
Spinu, V
Tiberi, S
Viiklepp, P
Lange, C
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Günther, G
van Leth, F
Altet, N
Dedicoat, M
Duarte, R
Gualano, G
Kunst, H
Muylle, I
Spinu, V
Tiberi, S
Viiklepp, P
Lange, C
dc.subject.por.fl_str_mv Multidrug-resistant tuberculosis
topic Multidrug-resistant tuberculosis
description The emergence of drug-resistant tuberculosis (TB) is a challenge to TB control in Europe. We evaluated second-line drug susceptibility testing in Mycobacterium tuberculosis isolates from patients with multidrug-resistant, pre-extensively drug-resistant (pre-XDR-TB) and XDR-TB at 23 TBNET sites in 16 European countries. Over 30% of bacilli from patients with pre-XDR-TB showed resistance to any fluoroquinolone and almost 70% to any second-line injectable drug. Respectively >90% and >80% of the XDR-TB strains tested showed phenotypic resistance to pyrazinamide and ethambutol. Resistance to prothionamide/ethionamide was high in bacilli from pre-XDR-TB patients (43%) and XDR-TB patients (49%).
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10216/114669
url http://hdl.handle.net/10216/114669
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1027-3719
10.5588/ijtld.15.0274
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