Multidrug-resistant tuberculosis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/13826 |
Resumo: | Texto completo. Acesso restrito. p. 239–246 |
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Lemos, Antônio Carlos MoreiraMatos, Eliana DiasLemos, Antônio Carlos MoreiraMatos, Eliana Dias2013-11-20T19:47:35Z20131413-8670http://repositorio.ufba.br/ri/handle/ri/13826v. 17, n. 2Texto completo. Acesso restrito. p. 239–246Despite the efforts made worldwide to reduce the number of cases of drug-susceptible tuberculosis, multidrug-resistant tuberculosis (MDR-TB) constitutes an important public health issue. Around 440,000 new cases of MDR-TB are estimated annually, although in 2008 only 7% of these (29,423 cases) were notified. The laboratory tests for diagnosing resistance may be phenotypic (based on culture growth in the presence of drugs) or genotypic (i.e. identification of the presence of mutations that confer resistance). The urgent need for a rapid means of detecting resistance to anti-TB drugs has resulted in the development of many genotypic methods over recent years. The treatment of MDR-TB is expensive, complex, prolonged (18–24 months) and associated with a higher incidence of adverse reactions. Some basic principles must be observed when prescribing an adequate treatment regimen for MDR-TB: (a) the association of at least four drugs (three of which should not have been used previously); (b) use of a fluoroquinolone; and (c) use of an injectable anti-TB drug. In Brazil, the therapeutic regimen for MDR-TB has been standardized and consists of five drugs: terizidone, levofloxacin, pyrazinamide, ethambutol and an aminoglycoside (streptomycin or amikacin). Pulmonary resection is an important tool in the coadjuvant treatment of MDRTB. While a recent meta-analysis revealed an average cure rate of MDR-TB of 69%, clinical studies are currently being conducted with new drugs and with drugs already available on the market but with a new indication for TB, with encouraging results that will enable more effective treatment regimens to be planned in the future.Submitted by Santiago Fabio (fabio.ssantiago@hotmail.com) on 2013-06-25T19:10:34Z No. of bitstreams: 1 333333333333333333.pdf: 322824 bytes, checksum: 28b3647f0e3bf157e026dacc5583f058 (MD5)Approved for entry into archive by Rodrigo Meirelles (rodrigomei@ufba.br) on 2013-11-20T19:47:35Z (GMT) No. of bitstreams: 1 333333333333333333.pdf: 322824 bytes, checksum: 28b3647f0e3bf157e026dacc5583f058 (MD5)Made available in DSpace on 2013-11-20T19:47:35Z (GMT). No. of bitstreams: 1 333333333333333333.pdf: 322824 bytes, checksum: 28b3647f0e3bf157e026dacc5583f058 (MD5) Previous issue date: 2013SalvadorThe Brazilian Journal of Infectious Diseaseshttp://dx.doi.org/10.1016/j.bjid.2013.01.007reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAMultidrug-resistant tuberculosisReviewDiagnosisTreatmentMultidrug-resistant tuberculosisThe Brazilian Journal of Infectious Diseasesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengORIGINAL333333333333333333.pdf333333333333333333.pdfapplication/pdf322824https://repositorio.ufba.br/bitstream/ri/13826/1/333333333333333333.pdf28b3647f0e3bf157e026dacc5583f058MD51LICENSElicense.txtlicense.txttext/plain1762https://repositorio.ufba.br/bitstream/ri/13826/2/license.txt1b89a9a0548218172d7c829f87a0eab9MD52TEXT333333333333333333.pdf.txt333333333333333333.pdf.txtExtracted texttext/plain43804https://repositorio.ufba.br/bitstream/ri/13826/3/333333333333333333.pdf.txtb110dd555dd6f4429f055213148e54d3MD53ri/138262022-07-05 14:02:52.252oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-07-05T17:02:52Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Multidrug-resistant tuberculosis |
| dc.title.alternative.pt_BR.fl_str_mv |
The Brazilian Journal of Infectious Diseases |
| title |
Multidrug-resistant tuberculosis |
| spellingShingle |
Multidrug-resistant tuberculosis Lemos, Antônio Carlos Moreira Multidrug-resistant tuberculosis Review Diagnosis Treatment |
| title_short |
Multidrug-resistant tuberculosis |
| title_full |
Multidrug-resistant tuberculosis |
| title_fullStr |
Multidrug-resistant tuberculosis |
| title_full_unstemmed |
Multidrug-resistant tuberculosis |
| title_sort |
Multidrug-resistant tuberculosis |
| author |
Lemos, Antônio Carlos Moreira |
| author_facet |
Lemos, Antônio Carlos Moreira Matos, Eliana Dias |
| author_role |
author |
| author2 |
Matos, Eliana Dias |
| author2_role |
author |
| dc.contributor.author.fl_str_mv |
Lemos, Antônio Carlos Moreira Matos, Eliana Dias Lemos, Antônio Carlos Moreira Matos, Eliana Dias |
| dc.subject.por.fl_str_mv |
Multidrug-resistant tuberculosis Review Diagnosis Treatment |
| topic |
Multidrug-resistant tuberculosis Review Diagnosis Treatment |
| description |
Texto completo. Acesso restrito. p. 239–246 |
| publishDate |
2013 |
| dc.date.accessioned.fl_str_mv |
2013-11-20T19:47:35Z |
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2013 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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1413-8670 |
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v. 17, n. 2 |
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1413-8670 v. 17, n. 2 |
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http://repositorio.ufba.br/ri/handle/ri/13826 |
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eng |
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The Brazilian Journal of Infectious Diseases |
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The Brazilian Journal of Infectious Diseases |
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http://dx.doi.org/10.1016/j.bjid.2013.01.007 |
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