Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/48412 |
Resumo: | Copyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3. |
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oai:repositorio.ul.pt:10451/48412 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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7160 |
spelling |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant dataCopyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3.Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.BMJ Publishing Group, Ltd.Repositório da Universidade de LisboaHolmes, M. V.Dale, C. E.Zuccolo, L.Silverwood, R. J.Guo, Y.Ye, Z.Prieto-Merino, D.Dehghan, A.Trompet, S.Wong, A.Cavadino, A.Rotter, J. I.Boerwinkle, E.Bakker, P. I. W. d.Kivimaki, M.Asselbergs, F. W.Sattar, N.Lawlor, D. A.Whittaker, J.Davey Smith, G.Yesupriya, A.Marmot, M. G.Mukamal, K.Psaty, B. M.Wilson, J. G.Lange, L. A.Hamidovic, A.Hingorani, A. D.Nordestgaard, B. G.Bobak, M.Leon, D. A.Langenberg, C.Ferro, JoséLeusink, M.Palmer, T. M.Reiner, A. P.Keating, B. J.Dudbridge, F.Casas, J. P.Sundstrom, J.Hubacek, J. A.Pikhart, H.Swerdlow, D. I.Paulos-Pinheiro, SofiaPanayiotou, A. G.Borinskaya, S. A.Finan, C.Shah, S.Kuchenbaecker, K. B.Shah, T.Engmann, J.Folkersen, L.Eriksson, P.Ricceri, F.Humphries, S. E.Melander, O.Sacerdote, C.Gamble, D. M.Rayaprolu, S.Ross, O. A.McLachlan, S.Vikhireva, O.Sluijs, I.Scott, R. A.Adamkova, V.Talmud, P. J.Flicker, L.Bockxmeer, F. M. v.Power, C.Marques-Vidal, PedroMeade, T.Leach, I. M.Verweij, N.Linneberg, A.Skaaby, T.Doevendans, P. A.Onland-Moret, N. C.Cramer, M. J.Harst, P. v. d.Klungel, O. H.Dowling, N. F.Dominiczak, A. F.Kumari, M.Nicolaides, A. N.Weikert, C.Boeing, H.Ebrahim, S.Hofker, M. H.Gaunt, T. R.Price, J. F.Lannfelt, L.Peasey, A.Kubinova, R.Pajak, A.Malyutina, S.Voevoda, M. I.Tamosiunas, A.Maitland-van der Zee, A. H.Wannamethee, S. G.Norman, P. E.Hankey, G. J.Bergmann, M. M.Hofman, A.Franco, O. H.Cooper, J.Palmen, J.Spiering, W.Jong, P. A. d.Kuh, D.Whincup, P. H.Hardy, R.Uitterlinden, A. G.Ikram, M. A.Ford, I.Hypponen, E.Almeida, O. P.Wareham, N. J.Khaw, K.-T.Hamsten, A.Husemoen, L. L. N.Morris, R.Tjonneland, A.Tolstrup, J. S.Rimm, E.Beulens, J. W. J.Verschuren, W. M. M.Vicente, A. M.Watkins, H.Farrall, M.Jukema, J. W.Meschia, J.Drogan, D.Cupples, L. A.Sharp, S. J.Fornage, M.Kooperberg, C.LaCroix, A. Z.Dai, J. Y.Lanktree, M. B.Siscovick, D. S.Jorgenson, E.Spring, B.Padmanabhan, S.Coresh, J.Li, Y. R.Buxbaum, S. G.Schreiner, P. J.Ellison, R. C.Tsai, M. Y.Patel, S. R.Redline, S.Johnson, A. D.Hoogeveen, R. C.Li, S.Hakonarson, H.2021-06-08T15:21:19Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48412engBMJ. 2014 Jul 10;349:g416410.1136/bmj.g41641756-1833info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:48Zoai:repositorio.ul.pt:10451/48412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:18.865088Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
title |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
spellingShingle |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data Holmes, M. V. |
title_short |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
title_full |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
title_fullStr |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
title_full_unstemmed |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
title_sort |
Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data |
author |
Holmes, M. V. |
author_facet |
Holmes, M. V. Dale, C. E. Zuccolo, L. Silverwood, R. J. Guo, Y. Ye, Z. Prieto-Merino, D. Dehghan, A. Trompet, S. Wong, A. Cavadino, A. Rotter, J. I. Boerwinkle, E. Bakker, P. I. W. d. Kivimaki, M. Asselbergs, F. W. Sattar, N. Lawlor, D. A. Whittaker, J. Davey Smith, G. Yesupriya, A. Marmot, M. G. Mukamal, K. Psaty, B. M. Wilson, J. G. Lange, L. A. Hamidovic, A. Hingorani, A. D. Nordestgaard, B. G. Bobak, M. Leon, D. A. Langenberg, C. Ferro, José Leusink, M. Palmer, T. M. Reiner, A. P. Keating, B. J. Dudbridge, F. Casas, J. P. Sundstrom, J. Hubacek, J. A. Pikhart, H. Swerdlow, D. I. Paulos-Pinheiro, Sofia Panayiotou, A. G. Borinskaya, S. A. Finan, C. Shah, S. Kuchenbaecker, K. B. Shah, T. Engmann, J. Folkersen, L. Eriksson, P. Ricceri, F. Humphries, S. E. Melander, O. Sacerdote, C. Gamble, D. M. Rayaprolu, S. Ross, O. A. McLachlan, S. Vikhireva, O. Sluijs, I. Scott, R. A. Adamkova, V. Talmud, P. J. Flicker, L. Bockxmeer, F. M. v. Power, C. Marques-Vidal, Pedro Meade, T. Leach, I. M. Verweij, N. Linneberg, A. Skaaby, T. Doevendans, P. A. Onland-Moret, N. C. Cramer, M. J. Harst, P. v. d. Klungel, O. H. Dowling, N. F. Dominiczak, A. F. Kumari, M. Nicolaides, A. N. Weikert, C. Boeing, H. Ebrahim, S. Hofker, M. H. Gaunt, T. R. Price, J. F. Lannfelt, L. Peasey, A. Kubinova, R. Pajak, A. Malyutina, S. Voevoda, M. I. Tamosiunas, A. Maitland-van der Zee, A. H. Wannamethee, S. G. Norman, P. E. Hankey, G. J. Bergmann, M. M. Hofman, A. Franco, O. H. Cooper, J. Palmen, J. Spiering, W. Jong, P. A. d. Kuh, D. Whincup, P. H. Hardy, R. Uitterlinden, A. G. Ikram, M. A. Ford, I. Hypponen, E. Almeida, O. P. Wareham, N. J. Khaw, K.-T. Hamsten, A. Husemoen, L. L. N. Morris, R. Tjonneland, A. Tolstrup, J. S. Rimm, E. Beulens, J. W. J. Verschuren, W. M. M. Vicente, A. M. Watkins, H. Farrall, M. Jukema, J. W. Meschia, J. Drogan, D. Cupples, L. A. Sharp, S. J. Fornage, M. Kooperberg, C. LaCroix, A. Z. Dai, J. Y. Lanktree, M. B. Siscovick, D. S. Jorgenson, E. Spring, B. Padmanabhan, S. Coresh, J. Li, Y. R. Buxbaum, S. G. Schreiner, P. J. Ellison, R. C. Tsai, M. Y. Patel, S. R. Redline, S. Johnson, A. D. Hoogeveen, R. C. Li, S. Hakonarson, H. |
author_role |
author |
author2 |
Dale, C. E. Zuccolo, L. Silverwood, R. J. Guo, Y. Ye, Z. Prieto-Merino, D. Dehghan, A. Trompet, S. Wong, A. Cavadino, A. Rotter, J. I. Boerwinkle, E. Bakker, P. I. W. d. Kivimaki, M. Asselbergs, F. W. Sattar, N. Lawlor, D. A. Whittaker, J. Davey Smith, G. Yesupriya, A. Marmot, M. G. Mukamal, K. Psaty, B. M. Wilson, J. G. Lange, L. A. Hamidovic, A. Hingorani, A. D. Nordestgaard, B. G. Bobak, M. Leon, D. A. Langenberg, C. Ferro, José Leusink, M. Palmer, T. M. Reiner, A. P. Keating, B. J. Dudbridge, F. Casas, J. P. Sundstrom, J. Hubacek, J. A. Pikhart, H. Swerdlow, D. I. Paulos-Pinheiro, Sofia Panayiotou, A. G. Borinskaya, S. A. Finan, C. Shah, S. Kuchenbaecker, K. B. Shah, T. Engmann, J. Folkersen, L. Eriksson, P. Ricceri, F. Humphries, S. E. Melander, O. Sacerdote, C. Gamble, D. M. Rayaprolu, S. Ross, O. A. McLachlan, S. Vikhireva, O. Sluijs, I. Scott, R. A. Adamkova, V. Talmud, P. J. Flicker, L. Bockxmeer, F. M. v. Power, C. Marques-Vidal, Pedro Meade, T. Leach, I. M. Verweij, N. Linneberg, A. Skaaby, T. Doevendans, P. A. Onland-Moret, N. C. Cramer, M. J. Harst, P. v. d. Klungel, O. H. Dowling, N. F. Dominiczak, A. F. Kumari, M. Nicolaides, A. N. Weikert, C. Boeing, H. Ebrahim, S. Hofker, M. H. Gaunt, T. R. Price, J. F. Lannfelt, L. Peasey, A. Kubinova, R. Pajak, A. Malyutina, S. Voevoda, M. I. Tamosiunas, A. Maitland-van der Zee, A. H. Wannamethee, S. G. Norman, P. E. Hankey, G. J. Bergmann, M. M. Hofman, A. Franco, O. H. Cooper, J. Palmen, J. Spiering, W. Jong, P. A. d. Kuh, D. Whincup, P. H. Hardy, R. Uitterlinden, A. G. Ikram, M. A. Ford, I. Hypponen, E. Almeida, O. P. Wareham, N. J. Khaw, K.-T. Hamsten, A. Husemoen, L. L. N. Morris, R. Tjonneland, A. Tolstrup, J. S. Rimm, E. Beulens, J. W. J. Verschuren, W. M. M. Vicente, A. M. Watkins, H. Farrall, M. Jukema, J. W. Meschia, J. Drogan, D. Cupples, L. A. Sharp, S. J. Fornage, M. Kooperberg, C. LaCroix, A. Z. Dai, J. Y. Lanktree, M. B. Siscovick, D. S. Jorgenson, E. Spring, B. Padmanabhan, S. Coresh, J. Li, Y. R. Buxbaum, S. G. Schreiner, P. J. Ellison, R. C. Tsai, M. Y. Patel, S. R. Redline, S. Johnson, A. D. Hoogeveen, R. C. Li, S. Hakonarson, H. |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Holmes, M. V. Dale, C. E. Zuccolo, L. Silverwood, R. J. Guo, Y. Ye, Z. Prieto-Merino, D. Dehghan, A. Trompet, S. Wong, A. Cavadino, A. Rotter, J. I. Boerwinkle, E. Bakker, P. I. W. d. Kivimaki, M. Asselbergs, F. W. Sattar, N. Lawlor, D. A. Whittaker, J. Davey Smith, G. Yesupriya, A. Marmot, M. G. Mukamal, K. Psaty, B. M. Wilson, J. G. Lange, L. A. Hamidovic, A. Hingorani, A. D. Nordestgaard, B. G. Bobak, M. Leon, D. A. Langenberg, C. Ferro, José Leusink, M. Palmer, T. M. Reiner, A. P. Keating, B. J. Dudbridge, F. Casas, J. P. Sundstrom, J. Hubacek, J. A. Pikhart, H. Swerdlow, D. I. Paulos-Pinheiro, Sofia Panayiotou, A. G. Borinskaya, S. A. Finan, C. Shah, S. Kuchenbaecker, K. B. Shah, T. Engmann, J. Folkersen, L. Eriksson, P. Ricceri, F. Humphries, S. E. Melander, O. Sacerdote, C. Gamble, D. M. Rayaprolu, S. Ross, O. A. McLachlan, S. Vikhireva, O. Sluijs, I. Scott, R. A. Adamkova, V. Talmud, P. J. Flicker, L. Bockxmeer, F. M. v. Power, C. Marques-Vidal, Pedro Meade, T. Leach, I. M. Verweij, N. Linneberg, A. Skaaby, T. Doevendans, P. A. Onland-Moret, N. C. Cramer, M. J. Harst, P. v. d. Klungel, O. H. Dowling, N. F. Dominiczak, A. F. Kumari, M. Nicolaides, A. N. Weikert, C. Boeing, H. Ebrahim, S. Hofker, M. H. Gaunt, T. R. Price, J. F. Lannfelt, L. Peasey, A. Kubinova, R. Pajak, A. Malyutina, S. Voevoda, M. I. Tamosiunas, A. Maitland-van der Zee, A. H. Wannamethee, S. G. Norman, P. E. Hankey, G. J. Bergmann, M. M. Hofman, A. Franco, O. H. Cooper, J. Palmen, J. Spiering, W. Jong, P. A. d. Kuh, D. Whincup, P. H. Hardy, R. Uitterlinden, A. G. Ikram, M. A. Ford, I. Hypponen, E. Almeida, O. P. Wareham, N. J. Khaw, K.-T. Hamsten, A. Husemoen, L. L. N. Morris, R. Tjonneland, A. Tolstrup, J. S. Rimm, E. Beulens, J. W. J. Verschuren, W. M. M. Vicente, A. M. Watkins, H. Farrall, M. Jukema, J. W. Meschia, J. Drogan, D. Cupples, L. A. Sharp, S. J. Fornage, M. Kooperberg, C. LaCroix, A. Z. Dai, J. Y. Lanktree, M. B. Siscovick, D. S. Jorgenson, E. Spring, B. Padmanabhan, S. Coresh, J. Li, Y. R. Buxbaum, S. G. Schreiner, P. J. Ellison, R. C. Tsai, M. Y. Patel, S. R. Redline, S. Johnson, A. D. Hoogeveen, R. C. Li, S. Hakonarson, H. |
description |
Copyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014 2014-01-01T00:00:00Z 2021-06-08T15:21:19Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/48412 |
url |
http://hdl.handle.net/10451/48412 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
BMJ. 2014 Jul 10;349:g4164 10.1136/bmj.g4164 1756-1833 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
BMJ Publishing Group, Ltd. |
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BMJ Publishing Group, Ltd. |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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