Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data

Detalhes bibliográficos
Autor(a) principal: Holmes, M. V.
Data de Publicação: 2014
Outros Autores: Dale, C. E., Zuccolo, L., Silverwood, R. J., Guo, Y., Ye, Z., Prieto-Merino, D., Dehghan, A., Trompet, S., Wong, A., Cavadino, A., Rotter, J. I., Boerwinkle, E., Bakker, P. I. W. d., Kivimaki, M., Asselbergs, F. W., Sattar, N., Lawlor, D. A., Whittaker, J., Davey Smith, G., Yesupriya, A., Marmot, M. G., Mukamal, K., Psaty, B. M., Wilson, J. G., Lange, L. A., Hamidovic, A., Hingorani, A. D., Nordestgaard, B. G., Bobak, M., Leon, D. A., Langenberg, C., Ferro, José, Leusink, M., Palmer, T. M., Reiner, A. P., Keating, B. J., Dudbridge, F., Casas, J. P., Sundstrom, J., Hubacek, J. A., Pikhart, H., Swerdlow, D. I., Paulos-Pinheiro, Sofia, Panayiotou, A. G., Borinskaya, S. A., Finan, C., Shah, S., Kuchenbaecker, K. B., Shah, T., Engmann, J., Folkersen, L., Eriksson, P., Ricceri, F., Humphries, S. E., Melander, O., Sacerdote, C., Gamble, D. M., Rayaprolu, S., Ross, O. A., McLachlan, S., Vikhireva, O., Sluijs, I., Scott, R. A., Adamkova, V., Talmud, P. J., Flicker, L., Bockxmeer, F. M. v., Power, C., Marques-Vidal, Pedro, Meade, T., Leach, I. M., Verweij, N., Linneberg, A., Skaaby, T., Doevendans, P. A., Onland-Moret, N. C., Cramer, M. J., Harst, P. v. d., Klungel, O. H., Dowling, N. F., Dominiczak, A. F., Kumari, M., Nicolaides, A. N., Weikert, C., Boeing, H., Ebrahim, S., Hofker, M. H., Gaunt, T. R., Price, J. F., Lannfelt, L., Peasey, A., Kubinova, R., Pajak, A., Malyutina, S., Voevoda, M. I., Tamosiunas, A., Maitland-van der Zee, A. H., Wannamethee, S. G., Norman, P. E., Hankey, G. J., Bergmann, M. M., Hofman, A., Franco, O. H., Cooper, J., Palmen, J., Spiering, W., Jong, P. A. d., Kuh, D., Whincup, P. H., Hardy, R., Uitterlinden, A. G., Ikram, M. A., Ford, I., Hypponen, E., Almeida, O. P., Wareham, N. J., Khaw, K.-T., Hamsten, A., Husemoen, L. L. N., Morris, R., Tjonneland, A., Tolstrup, J. S., Rimm, E., Beulens, J. W. J., Verschuren, W. M. M., Vicente, A. M., Watkins, H., Farrall, M., Jukema, J. W., Meschia, J., Drogan, D., Cupples, L. A., Sharp, S. J., Fornage, M., Kooperberg, C., LaCroix, A. Z., Dai, J. Y., Lanktree, M. B., Siscovick, D. S., Jorgenson, E., Spring, B., Padmanabhan, S., Coresh, J., Li, Y. R., Buxbaum, S. G., Schreiner, P. J., Ellison, R. C., Tsai, M. Y., Patel, S. R., Redline, S., Johnson, A. D., Hoogeveen, R. C., Li, S., Hakonarson, H.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/48412
Resumo: Copyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3.
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oai_identifier_str oai:repositorio.ul.pt:10451/48412
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network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant dataCopyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3.Objective: To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease. Design: Mendelian randomisation meta-analysis of 56 epidemiological studies. Participants: 261 991 individuals of European descent, including 20 259 coronary heart disease cases and 10 164 stroke events. Data were available on ADH1B rs1229984 variant, alcohol phenotypes, and cardiovascular biomarkers. Main outcome measures: Odds ratio for coronary heart disease and stroke associated with the ADH1B variant in all individuals and by categories of alcohol consumption. Results: Carriers of the A-allele of ADH1B rs1229984 consumed 17.2% fewer units of alcohol per week (95% confidence interval 15.6% to 18.9%), had a lower prevalence of binge drinking (odds ratio 0.78 (95% CI 0.73 to 0.84)), and had higher abstention (odds ratio 1.27 (1.21 to 1.34)) than non-carriers. Rs1229984 A-allele carriers had lower systolic blood pressure (-0.88 (-1.19 to -0.56) mm Hg), interleukin-6 levels (-5.2% (-7.8 to -2.4%)), waist circumference (-0.3 (-0.6 to -0.1) cm), and body mass index (-0.17 (-0.24 to -0.10) kg/m(2)). Rs1229984 A-allele carriers had lower odds of coronary heart disease (odds ratio 0.90 (0.84 to 0.96)). The protective association of the ADH1B rs1229984 A-allele variant remained the same across all categories of alcohol consumption (P=0.83 for heterogeneity). Although no association of rs1229984 was identified with the combined subtypes of stroke, carriers of the A-allele had lower odds of ischaemic stroke (odds ratio 0.83 (0.72 to 0.95)). Conclusions: Individuals with a genetic variant associated with non-drinking and lower alcohol consumption had a more favourable cardiovascular profile and a reduced risk of coronary heart disease than those without the genetic variant. This suggests that reduction of alcohol consumption, even for light to moderate drinkers, is beneficial for cardiovascular health.BMJ Publishing Group, Ltd.Repositório da Universidade de LisboaHolmes, M. V.Dale, C. E.Zuccolo, L.Silverwood, R. J.Guo, Y.Ye, Z.Prieto-Merino, D.Dehghan, A.Trompet, S.Wong, A.Cavadino, A.Rotter, J. I.Boerwinkle, E.Bakker, P. I. W. d.Kivimaki, M.Asselbergs, F. W.Sattar, N.Lawlor, D. A.Whittaker, J.Davey Smith, G.Yesupriya, A.Marmot, M. G.Mukamal, K.Psaty, B. M.Wilson, J. G.Lange, L. A.Hamidovic, A.Hingorani, A. D.Nordestgaard, B. G.Bobak, M.Leon, D. A.Langenberg, C.Ferro, JoséLeusink, M.Palmer, T. M.Reiner, A. P.Keating, B. J.Dudbridge, F.Casas, J. P.Sundstrom, J.Hubacek, J. A.Pikhart, H.Swerdlow, D. I.Paulos-Pinheiro, SofiaPanayiotou, A. G.Borinskaya, S. A.Finan, C.Shah, S.Kuchenbaecker, K. B.Shah, T.Engmann, J.Folkersen, L.Eriksson, P.Ricceri, F.Humphries, S. E.Melander, O.Sacerdote, C.Gamble, D. M.Rayaprolu, S.Ross, O. A.McLachlan, S.Vikhireva, O.Sluijs, I.Scott, R. A.Adamkova, V.Talmud, P. J.Flicker, L.Bockxmeer, F. M. v.Power, C.Marques-Vidal, PedroMeade, T.Leach, I. M.Verweij, N.Linneberg, A.Skaaby, T.Doevendans, P. A.Onland-Moret, N. C.Cramer, M. J.Harst, P. v. d.Klungel, O. H.Dowling, N. F.Dominiczak, A. F.Kumari, M.Nicolaides, A. N.Weikert, C.Boeing, H.Ebrahim, S.Hofker, M. H.Gaunt, T. R.Price, J. F.Lannfelt, L.Peasey, A.Kubinova, R.Pajak, A.Malyutina, S.Voevoda, M. I.Tamosiunas, A.Maitland-van der Zee, A. H.Wannamethee, S. G.Norman, P. E.Hankey, G. J.Bergmann, M. M.Hofman, A.Franco, O. H.Cooper, J.Palmen, J.Spiering, W.Jong, P. A. d.Kuh, D.Whincup, P. H.Hardy, R.Uitterlinden, A. G.Ikram, M. A.Ford, I.Hypponen, E.Almeida, O. P.Wareham, N. J.Khaw, K.-T.Hamsten, A.Husemoen, L. L. N.Morris, R.Tjonneland, A.Tolstrup, J. S.Rimm, E.Beulens, J. W. J.Verschuren, W. M. M.Vicente, A. M.Watkins, H.Farrall, M.Jukema, J. W.Meschia, J.Drogan, D.Cupples, L. A.Sharp, S. J.Fornage, M.Kooperberg, C.LaCroix, A. Z.Dai, J. Y.Lanktree, M. B.Siscovick, D. S.Jorgenson, E.Spring, B.Padmanabhan, S.Coresh, J.Li, Y. R.Buxbaum, S. G.Schreiner, P. J.Ellison, R. C.Tsai, M. Y.Patel, S. R.Redline, S.Johnson, A. D.Hoogeveen, R. C.Li, S.Hakonarson, H.2021-06-08T15:21:19Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/48412engBMJ. 2014 Jul 10;349:g416410.1136/bmj.g41641756-1833info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:51:48Zoai:repositorio.ul.pt:10451/48412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:18.865088Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
title Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
spellingShingle Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
Holmes, M. V.
title_short Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
title_full Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
title_fullStr Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
title_full_unstemmed Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
title_sort Association between alcohol and cardiovascular disease : Mendelian randomisation analysis based on individual participant data
author Holmes, M. V.
author_facet Holmes, M. V.
Dale, C. E.
Zuccolo, L.
Silverwood, R. J.
Guo, Y.
Ye, Z.
Prieto-Merino, D.
Dehghan, A.
Trompet, S.
Wong, A.
Cavadino, A.
Rotter, J. I.
Boerwinkle, E.
Bakker, P. I. W. d.
Kivimaki, M.
Asselbergs, F. W.
Sattar, N.
Lawlor, D. A.
Whittaker, J.
Davey Smith, G.
Yesupriya, A.
Marmot, M. G.
Mukamal, K.
Psaty, B. M.
Wilson, J. G.
Lange, L. A.
Hamidovic, A.
Hingorani, A. D.
Nordestgaard, B. G.
Bobak, M.
Leon, D. A.
Langenberg, C.
Ferro, José
Leusink, M.
Palmer, T. M.
Reiner, A. P.
Keating, B. J.
Dudbridge, F.
Casas, J. P.
Sundstrom, J.
Hubacek, J. A.
Pikhart, H.
Swerdlow, D. I.
Paulos-Pinheiro, Sofia
Panayiotou, A. G.
Borinskaya, S. A.
Finan, C.
Shah, S.
Kuchenbaecker, K. B.
Shah, T.
Engmann, J.
Folkersen, L.
Eriksson, P.
Ricceri, F.
Humphries, S. E.
Melander, O.
Sacerdote, C.
Gamble, D. M.
Rayaprolu, S.
Ross, O. A.
McLachlan, S.
Vikhireva, O.
Sluijs, I.
Scott, R. A.
Adamkova, V.
Talmud, P. J.
Flicker, L.
Bockxmeer, F. M. v.
Power, C.
Marques-Vidal, Pedro
Meade, T.
Leach, I. M.
Verweij, N.
Linneberg, A.
Skaaby, T.
Doevendans, P. A.
Onland-Moret, N. C.
Cramer, M. J.
Harst, P. v. d.
Klungel, O. H.
Dowling, N. F.
Dominiczak, A. F.
Kumari, M.
Nicolaides, A. N.
Weikert, C.
Boeing, H.
Ebrahim, S.
Hofker, M. H.
Gaunt, T. R.
Price, J. F.
Lannfelt, L.
Peasey, A.
Kubinova, R.
Pajak, A.
Malyutina, S.
Voevoda, M. I.
Tamosiunas, A.
Maitland-van der Zee, A. H.
Wannamethee, S. G.
Norman, P. E.
Hankey, G. J.
Bergmann, M. M.
Hofman, A.
Franco, O. H.
Cooper, J.
Palmen, J.
Spiering, W.
Jong, P. A. d.
Kuh, D.
Whincup, P. H.
Hardy, R.
Uitterlinden, A. G.
Ikram, M. A.
Ford, I.
Hypponen, E.
Almeida, O. P.
Wareham, N. J.
Khaw, K.-T.
Hamsten, A.
Husemoen, L. L. N.
Morris, R.
Tjonneland, A.
Tolstrup, J. S.
Rimm, E.
Beulens, J. W. J.
Verschuren, W. M. M.
Vicente, A. M.
Watkins, H.
Farrall, M.
Jukema, J. W.
Meschia, J.
Drogan, D.
Cupples, L. A.
Sharp, S. J.
Fornage, M.
Kooperberg, C.
LaCroix, A. Z.
Dai, J. Y.
Lanktree, M. B.
Siscovick, D. S.
Jorgenson, E.
Spring, B.
Padmanabhan, S.
Coresh, J.
Li, Y. R.
Buxbaum, S. G.
Schreiner, P. J.
Ellison, R. C.
Tsai, M. Y.
Patel, S. R.
Redline, S.
Johnson, A. D.
Hoogeveen, R. C.
Li, S.
Hakonarson, H.
author_role author
author2 Dale, C. E.
Zuccolo, L.
Silverwood, R. J.
Guo, Y.
Ye, Z.
Prieto-Merino, D.
Dehghan, A.
Trompet, S.
Wong, A.
Cavadino, A.
Rotter, J. I.
Boerwinkle, E.
Bakker, P. I. W. d.
Kivimaki, M.
Asselbergs, F. W.
Sattar, N.
Lawlor, D. A.
Whittaker, J.
Davey Smith, G.
Yesupriya, A.
Marmot, M. G.
Mukamal, K.
Psaty, B. M.
Wilson, J. G.
Lange, L. A.
Hamidovic, A.
Hingorani, A. D.
Nordestgaard, B. G.
Bobak, M.
Leon, D. A.
Langenberg, C.
Ferro, José
Leusink, M.
Palmer, T. M.
Reiner, A. P.
Keating, B. J.
Dudbridge, F.
Casas, J. P.
Sundstrom, J.
Hubacek, J. A.
Pikhart, H.
Swerdlow, D. I.
Paulos-Pinheiro, Sofia
Panayiotou, A. G.
Borinskaya, S. A.
Finan, C.
Shah, S.
Kuchenbaecker, K. B.
Shah, T.
Engmann, J.
Folkersen, L.
Eriksson, P.
Ricceri, F.
Humphries, S. E.
Melander, O.
Sacerdote, C.
Gamble, D. M.
Rayaprolu, S.
Ross, O. A.
McLachlan, S.
Vikhireva, O.
Sluijs, I.
Scott, R. A.
Adamkova, V.
Talmud, P. J.
Flicker, L.
Bockxmeer, F. M. v.
Power, C.
Marques-Vidal, Pedro
Meade, T.
Leach, I. M.
Verweij, N.
Linneberg, A.
Skaaby, T.
Doevendans, P. A.
Onland-Moret, N. C.
Cramer, M. J.
Harst, P. v. d.
Klungel, O. H.
Dowling, N. F.
Dominiczak, A. F.
Kumari, M.
Nicolaides, A. N.
Weikert, C.
Boeing, H.
Ebrahim, S.
Hofker, M. H.
Gaunt, T. R.
Price, J. F.
Lannfelt, L.
Peasey, A.
Kubinova, R.
Pajak, A.
Malyutina, S.
Voevoda, M. I.
Tamosiunas, A.
Maitland-van der Zee, A. H.
Wannamethee, S. G.
Norman, P. E.
Hankey, G. J.
Bergmann, M. M.
Hofman, A.
Franco, O. H.
Cooper, J.
Palmen, J.
Spiering, W.
Jong, P. A. d.
Kuh, D.
Whincup, P. H.
Hardy, R.
Uitterlinden, A. G.
Ikram, M. A.
Ford, I.
Hypponen, E.
Almeida, O. P.
Wareham, N. J.
Khaw, K.-T.
Hamsten, A.
Husemoen, L. L. N.
Morris, R.
Tjonneland, A.
Tolstrup, J. S.
Rimm, E.
Beulens, J. W. J.
Verschuren, W. M. M.
Vicente, A. M.
Watkins, H.
Farrall, M.
Jukema, J. W.
Meschia, J.
Drogan, D.
Cupples, L. A.
Sharp, S. J.
Fornage, M.
Kooperberg, C.
LaCroix, A. Z.
Dai, J. Y.
Lanktree, M. B.
Siscovick, D. S.
Jorgenson, E.
Spring, B.
Padmanabhan, S.
Coresh, J.
Li, Y. R.
Buxbaum, S. G.
Schreiner, P. J.
Ellison, R. C.
Tsai, M. Y.
Patel, S. R.
Redline, S.
Johnson, A. D.
Hoogeveen, R. C.
Li, S.
Hakonarson, H.
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dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Holmes, M. V.
Dale, C. E.
Zuccolo, L.
Silverwood, R. J.
Guo, Y.
Ye, Z.
Prieto-Merino, D.
Dehghan, A.
Trompet, S.
Wong, A.
Cavadino, A.
Rotter, J. I.
Boerwinkle, E.
Bakker, P. I. W. d.
Kivimaki, M.
Asselbergs, F. W.
Sattar, N.
Lawlor, D. A.
Whittaker, J.
Davey Smith, G.
Yesupriya, A.
Marmot, M. G.
Mukamal, K.
Psaty, B. M.
Wilson, J. G.
Lange, L. A.
Hamidovic, A.
Hingorani, A. D.
Nordestgaard, B. G.
Bobak, M.
Leon, D. A.
Langenberg, C.
Ferro, José
Leusink, M.
Palmer, T. M.
Reiner, A. P.
Keating, B. J.
Dudbridge, F.
Casas, J. P.
Sundstrom, J.
Hubacek, J. A.
Pikhart, H.
Swerdlow, D. I.
Paulos-Pinheiro, Sofia
Panayiotou, A. G.
Borinskaya, S. A.
Finan, C.
Shah, S.
Kuchenbaecker, K. B.
Shah, T.
Engmann, J.
Folkersen, L.
Eriksson, P.
Ricceri, F.
Humphries, S. E.
Melander, O.
Sacerdote, C.
Gamble, D. M.
Rayaprolu, S.
Ross, O. A.
McLachlan, S.
Vikhireva, O.
Sluijs, I.
Scott, R. A.
Adamkova, V.
Talmud, P. J.
Flicker, L.
Bockxmeer, F. M. v.
Power, C.
Marques-Vidal, Pedro
Meade, T.
Leach, I. M.
Verweij, N.
Linneberg, A.
Skaaby, T.
Doevendans, P. A.
Onland-Moret, N. C.
Cramer, M. J.
Harst, P. v. d.
Klungel, O. H.
Dowling, N. F.
Dominiczak, A. F.
Kumari, M.
Nicolaides, A. N.
Weikert, C.
Boeing, H.
Ebrahim, S.
Hofker, M. H.
Gaunt, T. R.
Price, J. F.
Lannfelt, L.
Peasey, A.
Kubinova, R.
Pajak, A.
Malyutina, S.
Voevoda, M. I.
Tamosiunas, A.
Maitland-van der Zee, A. H.
Wannamethee, S. G.
Norman, P. E.
Hankey, G. J.
Bergmann, M. M.
Hofman, A.
Franco, O. H.
Cooper, J.
Palmen, J.
Spiering, W.
Jong, P. A. d.
Kuh, D.
Whincup, P. H.
Hardy, R.
Uitterlinden, A. G.
Ikram, M. A.
Ford, I.
Hypponen, E.
Almeida, O. P.
Wareham, N. J.
Khaw, K.-T.
Hamsten, A.
Husemoen, L. L. N.
Morris, R.
Tjonneland, A.
Tolstrup, J. S.
Rimm, E.
Beulens, J. W. J.
Verschuren, W. M. M.
Vicente, A. M.
Watkins, H.
Farrall, M.
Jukema, J. W.
Meschia, J.
Drogan, D.
Cupples, L. A.
Sharp, S. J.
Fornage, M.
Kooperberg, C.
LaCroix, A. Z.
Dai, J. Y.
Lanktree, M. B.
Siscovick, D. S.
Jorgenson, E.
Spring, B.
Padmanabhan, S.
Coresh, J.
Li, Y. R.
Buxbaum, S. G.
Schreiner, P. J.
Ellison, R. C.
Tsai, M. Y.
Patel, S. R.
Redline, S.
Johnson, A. D.
Hoogeveen, R. C.
Li, S.
Hakonarson, H.
description Copyright © 2014, BMJ Publishing Group Ltd. This is an Open Access article distributed in accordance with the Creative CommonsAttribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute,remix, adapt, build upon this work non-commercially, and license their derivative workson different terms, provided the original work is properly cited and the use isnon-commercial. See: http://creativecommons.org/licenses/by-nc/3.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2021-06-08T15:21:19Z
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dc.relation.none.fl_str_mv BMJ. 2014 Jul 10;349:g4164
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1756-1833
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