Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine

Detalhes bibliográficos
Autor(a) principal: Iva Fernandes
Data de Publicação: 2009
Outros Autores: Nuno Vale, Victor de Freitas, Rui Moreira, Nuno Mateus, Paula Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/82030
Resumo: The growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated. Primaquine, N-dipeptidyl-primaquine derivatives, and other quinolines have been included in the study for comparison purposes. Primaquine and some of its derivatives were significantly active against the MCF-7 human breast cancer cell line, so these compounds might represent useful leads targeted at the development of novel specific agents against breast cancer. Conversely, all compounds were generally inactive against HT-29, with only one of the imidazoquines having IC(50) below 50 mu M. Activities against the Caco-2 cell line were modest and did not follow any defined trend.
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spelling Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquineCiências médicas e da saúdeMedical and Health sciencesThe growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated. Primaquine, N-dipeptidyl-primaquine derivatives, and other quinolines have been included in the study for comparison purposes. Primaquine and some of its derivatives were significantly active against the MCF-7 human breast cancer cell line, so these compounds might represent useful leads targeted at the development of novel specific agents against breast cancer. Conversely, all compounds were generally inactive against HT-29, with only one of the imidazoquines having IC(50) below 50 mu M. Activities against the Caco-2 cell line were modest and did not follow any defined trend.20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/82030eng0960-894X10.1016/j.bmcl.2009.10.081Iva FernandesNuno ValeVictor de FreitasRui MoreiraNuno MateusPaula Gomesinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T13:14:47Zoai:repositorio-aberto.up.pt:10216/82030Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:36:31.948611Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
title Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
spellingShingle Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
Iva Fernandes
Ciências médicas e da saúde
Medical and Health sciences
title_short Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
title_full Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
title_fullStr Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
title_full_unstemmed Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
title_sort Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine
author Iva Fernandes
author_facet Iva Fernandes
Nuno Vale
Victor de Freitas
Rui Moreira
Nuno Mateus
Paula Gomes
author_role author
author2 Nuno Vale
Victor de Freitas
Rui Moreira
Nuno Mateus
Paula Gomes
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Iva Fernandes
Nuno Vale
Victor de Freitas
Rui Moreira
Nuno Mateus
Paula Gomes
dc.subject.por.fl_str_mv Ciências médicas e da saúde
Medical and Health sciences
topic Ciências médicas e da saúde
Medical and Health sciences
description The growth inhibitory activity of imidazoquines, antimalarial imidazolidin-4-ones derived from primaquine, on human cancer cell lines HT-29, Caco-2, and MCF-7 has been evaluated. Primaquine, N-dipeptidyl-primaquine derivatives, and other quinolines have been included in the study for comparison purposes. Primaquine and some of its derivatives were significantly active against the MCF-7 human breast cancer cell line, so these compounds might represent useful leads targeted at the development of novel specific agents against breast cancer. Conversely, all compounds were generally inactive against HT-29, with only one of the imidazoquines having IC(50) below 50 mu M. Activities against the Caco-2 cell line were modest and did not follow any defined trend.
publishDate 2009
dc.date.none.fl_str_mv 2009
2009-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/82030
url https://hdl.handle.net/10216/82030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0960-894X
10.1016/j.bmcl.2009.10.081
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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