Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.25754/pjp.2019.15432 |
Resumo: | Background: Osteoarticular infections are commonly treated with long-course intravenous antibiotic therapy, leading to prolonged hospital stays. The aim of our study was to describe adverse events, namely adverse drug reactions, catheter associated complications and nosocomial infections, in paediatric patients treated for osteoarticular infections. Methods: Retrospective observational and analytical study of pediatric osteoarticular infections from 1994 to 2014 in a tertiary hospital. Patients were divided in two groups based on the presence of adverse events. Results: There were 134 patients treated with intravenous antibiotic therapy, with a median length of 19.5 (IQR: 14.0-27.3) days. Adverse events occurred in 73,1% of patients (n=98). Adverse drug reactions (n=67) occurred in 50,0% of the patients and were associated with longer duration of parenteral treatment and vancomycin prescription. Catheter associated complications (29,1%; n=39) included catheter-infiltration (13.4%), thrombophlebitis (9.7%) and cellulitis (6.0%). Thirty-three patients had nosocomial infections, mainly gastrointestinal (11.2%) and respiratory (8.2%). Comparing the groups with and without adverse events, there were no significant clinical or analytical differences, at admission and after starting antibiotic therapy, except for the duration of iv treatment and total length of hospital stay, which were significantly higher in patients with adverse events. Conclusions: Long-course intravenous antibiotic therapy for osteoarticular infections is frequently associated with adverse events. In patients with clinical and analytical improvement, early transition from intravenous to oral treatment should be considered in order to reduce the incidence and morbidity of these complications. |
id |
RCAP_60ece087cc632f462f25bc9797576a3b |
---|---|
oai_identifier_str |
oai:ojs.revistas.rcaap.pt:article/15432 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular InfectionsEventos adversos em antibioterapia endovenosa prolongada nas infeções osteoarticulares pediátricasOriginal articlesBackground: Osteoarticular infections are commonly treated with long-course intravenous antibiotic therapy, leading to prolonged hospital stays. The aim of our study was to describe adverse events, namely adverse drug reactions, catheter associated complications and nosocomial infections, in paediatric patients treated for osteoarticular infections. Methods: Retrospective observational and analytical study of pediatric osteoarticular infections from 1994 to 2014 in a tertiary hospital. Patients were divided in two groups based on the presence of adverse events. Results: There were 134 patients treated with intravenous antibiotic therapy, with a median length of 19.5 (IQR: 14.0-27.3) days. Adverse events occurred in 73,1% of patients (n=98). Adverse drug reactions (n=67) occurred in 50,0% of the patients and were associated with longer duration of parenteral treatment and vancomycin prescription. Catheter associated complications (29,1%; n=39) included catheter-infiltration (13.4%), thrombophlebitis (9.7%) and cellulitis (6.0%). Thirty-three patients had nosocomial infections, mainly gastrointestinal (11.2%) and respiratory (8.2%). Comparing the groups with and without adverse events, there were no significant clinical or analytical differences, at admission and after starting antibiotic therapy, except for the duration of iv treatment and total length of hospital stay, which were significantly higher in patients with adverse events. Conclusions: Long-course intravenous antibiotic therapy for osteoarticular infections is frequently associated with adverse events. In patients with clinical and analytical improvement, early transition from intravenous to oral treatment should be considered in order to reduce the incidence and morbidity of these complications.Introdução: As infecções osteoarticulares são habitualmente tratadas com antibioterapia endovenosa de longa duração, levando a internamentos prolongados. O objetivo do nosso estudo foi descrever os eventos adversos, nomeadamente, reações adversas a medicamentos, complicações associadas ao cateter e infecções nosocomiais, em pacientes pediátricos tratados para infecções osteoarticulares. Métodos: Estudo observacional e analítico retrospectivo de infecções osteoarticulares pediátricas, de 1994 a 2014, num hospital terciário. Os pacientes foram divididos em dois grupos com base na presença de eventos adversos. Resultados: Cento e trinta e quarto pacientes foram tratados com antibioterapia endovenosa, com duração mediana de 19,5 (IQR: 14,0-27,3) dias. Eventos adversos ocorreram em 73,1% dos pacientes (n = 98). Reações adversas a medicamentos (n = 67) ocorreram em 50,0% dos pacientes e estiveram associadas a maior duração do tratamento parentérico e à prescrição de vancomicina. As complicações associadas ao cateter (29,1%; n = 39) incluíram infiltração por cateter (13,4%), tromboflebite (9,7%) e celulite (6,0%). Trinta e três pacientes tiveram infeções nosocomiais, principalmente gastrointestinais (11,2%) e respiratórias (8,2%). Comparando os grupos com e sem eventos adversos, não houve diferenças clínicas ou analíticas significativas, na admissão e após o início da antibioterapia, exceto na duração do tratamento endovenoso e no tempo total de internamento, que foram significativamente maiores em pacientes com eventos adversos. Conclusões: A antibioterapia endovenosa de longa duração para infecções osteoarticulares é frequentemente associada a eventos adversos. Em pacientes com melhoria clínica e analítica, a transição precoce do tratamento intravenoso para oral deve ser considerada, a fim de reduzir a incidência e a morbilidade destas complicações.Sociedade Portuguesa de Pediatria2019-07-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttps://doi.org/10.25754/pjp.2019.15432eng2184-44532184-3333Alves, SérgioRangel, Maria AdrianaBaptista, CarolinaSantos, MafaldaRodrigues, LúciaMoreira, Dianainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T02:57:56Zoai:ojs.revistas.rcaap.pt:article/15432Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:25:30.288560Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections Eventos adversos em antibioterapia endovenosa prolongada nas infeções osteoarticulares pediátricas |
title |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
spellingShingle |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections Alves, Sérgio Original articles |
title_short |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
title_full |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
title_fullStr |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
title_full_unstemmed |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
title_sort |
Adverse Events in Long-Course Intravenous Antibiotic Therapy for Pediatric Osteoarticular Infections |
author |
Alves, Sérgio |
author_facet |
Alves, Sérgio Rangel, Maria Adriana Baptista, Carolina Santos, Mafalda Rodrigues, Lúcia Moreira, Diana |
author_role |
author |
author2 |
Rangel, Maria Adriana Baptista, Carolina Santos, Mafalda Rodrigues, Lúcia Moreira, Diana |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alves, Sérgio Rangel, Maria Adriana Baptista, Carolina Santos, Mafalda Rodrigues, Lúcia Moreira, Diana |
dc.subject.por.fl_str_mv |
Original articles |
topic |
Original articles |
description |
Background: Osteoarticular infections are commonly treated with long-course intravenous antibiotic therapy, leading to prolonged hospital stays. The aim of our study was to describe adverse events, namely adverse drug reactions, catheter associated complications and nosocomial infections, in paediatric patients treated for osteoarticular infections. Methods: Retrospective observational and analytical study of pediatric osteoarticular infections from 1994 to 2014 in a tertiary hospital. Patients were divided in two groups based on the presence of adverse events. Results: There were 134 patients treated with intravenous antibiotic therapy, with a median length of 19.5 (IQR: 14.0-27.3) days. Adverse events occurred in 73,1% of patients (n=98). Adverse drug reactions (n=67) occurred in 50,0% of the patients and were associated with longer duration of parenteral treatment and vancomycin prescription. Catheter associated complications (29,1%; n=39) included catheter-infiltration (13.4%), thrombophlebitis (9.7%) and cellulitis (6.0%). Thirty-three patients had nosocomial infections, mainly gastrointestinal (11.2%) and respiratory (8.2%). Comparing the groups with and without adverse events, there were no significant clinical or analytical differences, at admission and after starting antibiotic therapy, except for the duration of iv treatment and total length of hospital stay, which were significantly higher in patients with adverse events. Conclusions: Long-course intravenous antibiotic therapy for osteoarticular infections is frequently associated with adverse events. In patients with clinical and analytical improvement, early transition from intravenous to oral treatment should be considered in order to reduce the incidence and morbidity of these complications. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-07-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.25754/pjp.2019.15432 |
url |
https://doi.org/10.25754/pjp.2019.15432 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2184-4453 2184-3333 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Pediatria |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799133524296466433 |