Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis

Detalhes bibliográficos
Autor(a) principal: Paula, Débora Holanda Gonçalves de
Data de Publicação: 2012
Outros Autores: Tura, Bernardo Rangel, Lamas, Cristiane da Cruz
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36432
Resumo: Cristiane da Cruz Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Paula, Débora Holanda Gonçalves deTura, Bernardo RangelLamas, Cristiane da Cruz2019-10-15T12:27:26Z2019-10-15T12:27:26Z2012PAULA, Débora Holanda Gonçalves de; TURA, Bernardo Rangel; LAMAS, Cristiane da Cruz. Adverse events related to intravenous antibiotic therapy: a prospective observational study in the treatment of infective endocarditis. BMJ Open, v. 2, p.1-6, 2012.2044-6055https://www.arca.fiocruz.br/handle/icict/3643210.1136/bmjopen-2012-0011892044-6055Cristiane da Cruz Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.Department of Surgery, Instituto Nacional de Cardiologia, Rio de Janeiro, BrazilDepartment of Biostatistics and Bioinformatics, Instituto Nacional de Cardiologia, Rio de Janeiro, BrazilUniversidade do Grande Rio. Duque de Caxias, RJ, Brasil / Instituto Nacional de Cardiologia. Infection Control Committee. Rio de Janeiro, RJ, Brazil.Objective: The goal of this prospective observational study was to identify adverse events (AEs) related to the use of intravenous access sites used for infective endocarditis (IE) treatment in a tertiary care hospital. Design: This is an observational, analytical and prospective study on AEs resulting from the use of intravenous access sites in patients under antimicrobial treatment for IE. Patients enrolled in the International Collaboration on Endocarditis (ICE) study had their peripheral, short-term central catheters (CVC) and peripherally inserted central catheters (PICC) monitored for AEs. Setting: Tertiary care hospital for cardiac surgery in Rio de Janeiro, Brazil. Patients: Patients over 14 years of age, hospitalised in 2009 and 2010 with possible or definite criteria for IE by the modified Duke criteria were included. Main outcome measures: AEs related to intravenous catheters: erythema and infiltration, fever, obstruction, externalisation and blood stream infection. Results: Thirty-seven episodes of IE in 35 patients were studied. Mean patient age was 44.32±15.2 years; 22 (63%) were men. The number of vascular catheters studied were 253, 148 of which were peripheral, 85 CVC (21 of which for haemodialysis) and 20 PICC. The most frequent AEs were ‘erythema’ and ‘infiltration’ for peripheral catheters, ‘fever’ for CVCs and ‘obstruction’ and ‘externalisation’ for PICCs. The number of catheterdays was 360 for peripheral catheters, 1.156 for CVC and 420 for PICC. Kaplan-Meier curves for CVC and PICC showed statistical difference for obstruction (p<0.001) in PICCs. More bacteraemia occurred in CVC compared with PICC. Conclusions: The choice of intravenous access sites is critical in the treatment of IE. Close observation for AEs and stricter implementation of infection control measures and better manipulation of catheters are suggested.engBMJ Publishing GroupAdverse events related to intravenous antibiotic therapy in the treatment of infective endocarditisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleInfective endocarditisIntravenous antibiotic therapyAdverse eventsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36432/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Paula_Débora_etal_INI_2012.pdfve_Paula_Débora_etal_INI_2012.pdfapplication/pdf202806https://www.arca.fiocruz.br/bitstream/icict/36432/2/ve_Paula_D%c3%a9bora_etal_INI_2012.pdf519c5c0c7f2d86f676d94d2a75b68936MD52TEXTve_Paula_Débora_etal_INI_2012.pdf.txtve_Paula_Débora_etal_INI_2012.pdf.txtExtracted texttext/plain33299https://www.arca.fiocruz.br/bitstream/icict/36432/3/ve_Paula_D%c3%a9bora_etal_INI_2012.pdf.txtf406c05214354faefa73921d7fe57f90MD53icict/364322019-10-16 02:04:29.0oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-10-16T05:04:29Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
title Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
spellingShingle Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
Paula, Débora Holanda Gonçalves de
Infective endocarditis
Intravenous antibiotic therapy
Adverse events
title_short Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
title_full Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
title_fullStr Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
title_full_unstemmed Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
title_sort Adverse events related to intravenous antibiotic therapy in the treatment of infective endocarditis
author Paula, Débora Holanda Gonçalves de
author_facet Paula, Débora Holanda Gonçalves de
Tura, Bernardo Rangel
Lamas, Cristiane da Cruz
author_role author
author2 Tura, Bernardo Rangel
Lamas, Cristiane da Cruz
author2_role author
author
dc.contributor.author.fl_str_mv Paula, Débora Holanda Gonçalves de
Tura, Bernardo Rangel
Lamas, Cristiane da Cruz
dc.subject.en.pt_BR.fl_str_mv Infective endocarditis
Intravenous antibiotic therapy
Adverse events
topic Infective endocarditis
Intravenous antibiotic therapy
Adverse events
description Cristiane da Cruz Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-15T12:27:26Z
dc.date.available.fl_str_mv 2019-10-15T12:27:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAULA, Débora Holanda Gonçalves de; TURA, Bernardo Rangel; LAMAS, Cristiane da Cruz. Adverse events related to intravenous antibiotic therapy: a prospective observational study in the treatment of infective endocarditis. BMJ Open, v. 2, p.1-6, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36432
dc.identifier.issn.pt_BR.fl_str_mv 2044-6055
dc.identifier.doi.none.fl_str_mv 10.1136/bmjopen-2012-001189
dc.identifier.eissn.none.fl_str_mv 2044-6055
identifier_str_mv PAULA, Débora Holanda Gonçalves de; TURA, Bernardo Rangel; LAMAS, Cristiane da Cruz. Adverse events related to intravenous antibiotic therapy: a prospective observational study in the treatment of infective endocarditis. BMJ Open, v. 2, p.1-6, 2012.
2044-6055
10.1136/bmjopen-2012-001189
url https://www.arca.fiocruz.br/handle/icict/36432
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMJ Publishing Group
publisher.none.fl_str_mv BMJ Publishing Group
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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