Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/3999 |
Resumo: | Erratum in: Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. [Neurology. 2016] |
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Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaborationDoenças Cardio e Cérebro-vascularesIschemic StrokeErratum in: Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. [Neurology. 2016]Objective: To investigate the influence of common and low-frequency genetic variants on the risk of ischemic stroke (all IS) and etiologic stroke subtypes. Methods: We meta-analyzed 12 individual genome-wide association studies comprising 10,307 cases and 19,326 controls imputed to the 1000 Genomes (1 KG) phase I reference panel. We selected variants showing the highest degree of association (p , 1E-5) in the discovery phase for replication in Caucasian (13,435 cases and 29,269 controls) and South Asian (2,385 cases and 5,193 controls) samples followed by a transethnic meta-analysis. We further investigated the p value distribution for different bins of allele frequencies for all IS and stroke subtypes. Results: We showed genome-wide significance for 4 loci: ABO for all IS, HDAC9 for large vessel disease (LVD), and both PITX2 and ZFHX3 for cardioembolic stroke (CE). We further refined the association peaks for ABO and PITX2. Analyzing different allele frequency bins, we showed significant enrichment in low-frequency variants (allele frequency ,5%) for both LVD and small vessel disease, and an enrichment of higher frequency variants (allele frequency 10% and 30%) for CE (all p , 1E-5). Conclusions: Our findings suggest that the missing heritability in IS subtypes can in part be attributed to low-frequency and rare variants. Larger sample sizes are needed to identify the variants associated with all IS and stroke subtypes.American Academy of NeurologyRepositório Científico do Instituto Nacional de SaúdeMalik, R.Traylor, M.Pulit, S.L.Bevan, S.Hopewell, J.C.Holliday, E.G.Zhao, W.Abrantes, P.Amouyel, P.Attia, J.R.Battey, T.W.Berger, K.Boncoraglio, G.B.Chauhan, G.Cheng, Y.C.Chen, W.M.Clarke, R.Cotlarciuc, I.Debette, S.Falcone, G.J.Ferro, J.M.Gamble, D.M.Ilinca, A.Kittner, S.J.Kourkoulis, C.E.Lemmens, R.Levi, C.R.Lichtner, P.Lindgren, A.Liu, J.Meschia, J.F.Mitchell, B.D.Oliveira, S.A.Pera, J.Reiner, A.P.Rothwell, P.M.Sharma, P.Slowik, A.Sudlow, C.L.Tatlisumak, T.Thijs, V.Vicente, A.M.Woo, D.Seshadri, S.Saleheen, D.Rosand, J.Markus, H.S.Worrall, B.B.Dichgans, M.ISGC Analysis GroupMETASTROKE collaborationWellcome Trust Case Control Consortium 2 (WTCCC2)NINDS Stroke Genetics Network (SiGN)2017-04-01T00:30:10Z2016-032016-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3999engNeurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528. Epub 2016 Mar 2.0028-387810.1212/WNL.0000000000002528info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:40:07Zoai:repositorio.insa.pt:10400.18/3999Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:52.691575Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
title |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
spellingShingle |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration Malik, R. Doenças Cardio e Cérebro-vasculares Ischemic Stroke |
title_short |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
title_full |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
title_fullStr |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
title_full_unstemmed |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
title_sort |
Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration |
author |
Malik, R. |
author_facet |
Malik, R. Traylor, M. Pulit, S.L. Bevan, S. Hopewell, J.C. Holliday, E.G. Zhao, W. Abrantes, P. Amouyel, P. Attia, J.R. Battey, T.W. Berger, K. Boncoraglio, G.B. Chauhan, G. Cheng, Y.C. Chen, W.M. Clarke, R. Cotlarciuc, I. Debette, S. Falcone, G.J. Ferro, J.M. Gamble, D.M. Ilinca, A. Kittner, S.J. Kourkoulis, C.E. Lemmens, R. Levi, C.R. Lichtner, P. Lindgren, A. Liu, J. Meschia, J.F. Mitchell, B.D. Oliveira, S.A. Pera, J. Reiner, A.P. Rothwell, P.M. Sharma, P. Slowik, A. Sudlow, C.L. Tatlisumak, T. Thijs, V. Vicente, A.M. Woo, D. Seshadri, S. Saleheen, D. Rosand, J. Markus, H.S. Worrall, B.B. Dichgans, M. ISGC Analysis Group METASTROKE collaboration Wellcome Trust Case Control Consortium 2 (WTCCC2) NINDS Stroke Genetics Network (SiGN) |
author_role |
author |
author2 |
Traylor, M. Pulit, S.L. Bevan, S. Hopewell, J.C. Holliday, E.G. Zhao, W. Abrantes, P. Amouyel, P. Attia, J.R. Battey, T.W. Berger, K. Boncoraglio, G.B. Chauhan, G. Cheng, Y.C. Chen, W.M. Clarke, R. Cotlarciuc, I. Debette, S. Falcone, G.J. Ferro, J.M. Gamble, D.M. Ilinca, A. Kittner, S.J. Kourkoulis, C.E. Lemmens, R. Levi, C.R. Lichtner, P. Lindgren, A. Liu, J. Meschia, J.F. Mitchell, B.D. Oliveira, S.A. Pera, J. Reiner, A.P. Rothwell, P.M. Sharma, P. Slowik, A. Sudlow, C.L. Tatlisumak, T. Thijs, V. Vicente, A.M. Woo, D. Seshadri, S. Saleheen, D. Rosand, J. Markus, H.S. Worrall, B.B. Dichgans, M. ISGC Analysis Group METASTROKE collaboration Wellcome Trust Case Control Consortium 2 (WTCCC2) NINDS Stroke Genetics Network (SiGN) |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Malik, R. Traylor, M. Pulit, S.L. Bevan, S. Hopewell, J.C. Holliday, E.G. Zhao, W. Abrantes, P. Amouyel, P. Attia, J.R. Battey, T.W. Berger, K. Boncoraglio, G.B. Chauhan, G. Cheng, Y.C. Chen, W.M. Clarke, R. Cotlarciuc, I. Debette, S. Falcone, G.J. Ferro, J.M. Gamble, D.M. Ilinca, A. Kittner, S.J. Kourkoulis, C.E. Lemmens, R. Levi, C.R. Lichtner, P. Lindgren, A. Liu, J. Meschia, J.F. Mitchell, B.D. Oliveira, S.A. Pera, J. Reiner, A.P. Rothwell, P.M. Sharma, P. Slowik, A. Sudlow, C.L. Tatlisumak, T. Thijs, V. Vicente, A.M. Woo, D. Seshadri, S. Saleheen, D. Rosand, J. Markus, H.S. Worrall, B.B. Dichgans, M. ISGC Analysis Group METASTROKE collaboration Wellcome Trust Case Control Consortium 2 (WTCCC2) NINDS Stroke Genetics Network (SiGN) |
dc.subject.por.fl_str_mv |
Doenças Cardio e Cérebro-vasculares Ischemic Stroke |
topic |
Doenças Cardio e Cérebro-vasculares Ischemic Stroke |
description |
Erratum in: Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration. [Neurology. 2016] |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-03 2016-03-01T00:00:00Z 2017-04-01T00:30:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/3999 |
url |
http://hdl.handle.net/10400.18/3999 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Neurology. 2016 Mar 29;86(13):1217-26. doi: 10.1212/WNL.0000000000002528. Epub 2016 Mar 2. 0028-3878 10.1212/WNL.0000000000002528 |
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info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
American Academy of Neurology |
publisher.none.fl_str_mv |
American Academy of Neurology |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132126052876288 |