Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/36185 |
Resumo: | Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs. |
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Tuning the drug multimodal release through a co-assembly strategy based on magnetic gelsSelf-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs.Royal Society of Chemistry2023-04-14T00:00:00Z2022-04-14T00:00:00Z2022-04-14info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10773/36185eng2040-336410.1039/D1NR08158FVeloso, Sérgio R. S.Tiryaki, EcemSpuch, CarlosHilliou, LoicAmorim, C. O.Amaral, V. S.Coutinho, Paulo J. G.Ferreira, Paula M. T.Salgueiriño, VerónicaCorrea-Duarte, Miguel A.Castanheira, Elisabete M. S.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T12:09:34Zoai:ria.ua.pt:10773/36185Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:06:59.634884Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
spellingShingle |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels Veloso, Sérgio R. S. |
title_short |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_full |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_fullStr |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_full_unstemmed |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
title_sort |
Tuning the drug multimodal release through a co-assembly strategy based on magnetic gels |
author |
Veloso, Sérgio R. S. |
author_facet |
Veloso, Sérgio R. S. Tiryaki, Ecem Spuch, Carlos Hilliou, Loic Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueiriño, Verónica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
author_role |
author |
author2 |
Tiryaki, Ecem Spuch, Carlos Hilliou, Loic Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueiriño, Verónica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Veloso, Sérgio R. S. Tiryaki, Ecem Spuch, Carlos Hilliou, Loic Amorim, C. O. Amaral, V. S. Coutinho, Paulo J. G. Ferreira, Paula M. T. Salgueiriño, Verónica Correa-Duarte, Miguel A. Castanheira, Elisabete M. S. |
description |
Self-assembled short peptide-based gels are highly promising drug delivery systems. However, implementing a stimulus often requires screening different structures to obtain gels with suitable properties, and drugs might not be well encapsulated and/or cause undesirable effects on the gel's properties. To overcome this challenge, a new design approach is presented to modulate the release of doxorubicin as a model chemotherapeutic drug through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and doxorubicin co-assembly in dehydropeptide-based gels. The composites enable an enhancement of the gelation kinetics in a concentration-dependent manner, mainly through the use of PEGylated liposomes. The effect of the co-assembly of phenylalanine-coated nanoparticles with the hydrogel displays a concentration and size dependence. Finally, the integration of liposomes as doxorubicin storage units and of nanoparticles as composites that co-assemble with the gel matrix enables the tuneability of both passive and active doxorubicin release through a thermal, and a low-frequency alternating magnetic field-based trigger. In addition to the modulation of the gel properties, the functionalization with (di)phenylalanine improves the cytocompatibility of the nanoparticles. Hereby, this work paves a way for the development of peptide-based supramolecular systems for on-demand and controlled release of drugs. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-14T00:00:00Z 2022-04-14 2023-04-14T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/36185 |
url |
http://hdl.handle.net/10773/36185 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2040-3364 10.1039/D1NR08158F |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137725007265792 |