45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method

Detalhes bibliográficos
Autor(a) principal: Siqueira, L
Data de Publicação: 2021
Outros Autores: Grenho, L, Fernandes, MH, Monteiro, FJ, Trichês, ES
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://hdl.handle.net/10216/152441
Resumo: Scaffolds of bioglass derived from BG45S5 (45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O and 6 wt% P2O5) containing 10 wt% niobium were prepared by gelcasting method. The scaffolds presented a 3D porous structure with interconnected and spherical pores (pore size range 100 µm to 500 µm) and high porosity (89%), similar to trabecular architecture of spongy bone. The compressive strength was 0.18 ± 0.03 MPa which is acceptable for bone repair applications. The in vitro biological studies showed cytocompatibility for human osteoblastic cells as well tendency for higher alkaline phosphatase activity. Therefore, the findings here suggest the great potential of the scaffolds for using in bone tissue engineering.
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spelling 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting methodBioglassBone tissue engineeringGelcasting methodNiobium oxidePorous materialsScaffoldScaffolds of bioglass derived from BG45S5 (45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O and 6 wt% P2O5) containing 10 wt% niobium were prepared by gelcasting method. The scaffolds presented a 3D porous structure with interconnected and spherical pores (pore size range 100 µm to 500 µm) and high porosity (89%), similar to trabecular architecture of spongy bone. The compressive strength was 0.18 ± 0.03 MPa which is acceptable for bone repair applications. The in vitro biological studies showed cytocompatibility for human osteoblastic cells as well tendency for higher alkaline phosphatase activity. Therefore, the findings here suggest the great potential of the scaffolds for using in bone tissue engineering.ABM; ABC; ABPol20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10216/152441eng1516-143910.1590/1980-5373-MR-2020-0403Siqueira, LGrenho, LFernandes, MHMonteiro, FJTrichês, ESinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-29T15:08:29Zoai:repositorio-aberto.up.pt:10216/152441Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:16:35.328371Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
title 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
spellingShingle 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
Siqueira, L
Bioglass
Bone tissue engineering
Gelcasting method
Niobium oxide
Porous materials
Scaffold
title_short 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
title_full 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
title_fullStr 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
title_full_unstemmed 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
title_sort 45S5 bioglass-derived glass-ceramic scaffolds containing niobium obtained by gelcasting method
author Siqueira, L
author_facet Siqueira, L
Grenho, L
Fernandes, MH
Monteiro, FJ
Trichês, ES
author_role author
author2 Grenho, L
Fernandes, MH
Monteiro, FJ
Trichês, ES
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Siqueira, L
Grenho, L
Fernandes, MH
Monteiro, FJ
Trichês, ES
dc.subject.por.fl_str_mv Bioglass
Bone tissue engineering
Gelcasting method
Niobium oxide
Porous materials
Scaffold
topic Bioglass
Bone tissue engineering
Gelcasting method
Niobium oxide
Porous materials
Scaffold
description Scaffolds of bioglass derived from BG45S5 (45 wt% SiO2, 24.5 wt% CaO, 24.5 wt% Na2O and 6 wt% P2O5) containing 10 wt% niobium were prepared by gelcasting method. The scaffolds presented a 3D porous structure with interconnected and spherical pores (pore size range 100 µm to 500 µm) and high porosity (89%), similar to trabecular architecture of spongy bone. The compressive strength was 0.18 ± 0.03 MPa which is acceptable for bone repair applications. The in vitro biological studies showed cytocompatibility for human osteoblastic cells as well tendency for higher alkaline phosphatase activity. Therefore, the findings here suggest the great potential of the scaffolds for using in bone tissue engineering.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://hdl.handle.net/10216/152441
url https://hdl.handle.net/10216/152441
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1516-1439
10.1590/1980-5373-MR-2020-0403
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv ABM; ABC; ABPol
publisher.none.fl_str_mv ABM; ABC; ABPol
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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