Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation

Detalhes bibliográficos
Autor(a) principal: Tankisi, Hatice
Data de Publicação: 2021
Outros Autores: Nielsen, Christina S.‐Z., Howells, James, Cengiz, Bülent, Samusyte, Gintaute, Koltzenburg, Martin, Blicher, Jakob U., Møller, Anette T., Pugdahl, Kirsten, Fuglsang‐Frederiksen, Anders, Carvalho, Mamede, Bostock, Hugh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/49628
Resumo: © 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
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spelling Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulationAmyotrophic lateral sclerosisConventional TMSShort-interval intracortical inhibitionThreshold tracking TMSTranscranial magnetic stimulation© 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.Background and purpose: Short-interval intracortical inhibition by threshold tracking (T-SICI) has been proposed as a diagnostic tool for amyotrophic lateral sclerosis (ALS) but has not been compared directly with conventional amplitude measurements (A-SICI). This study compared A-SICI and T-SICI for sensitivity and clinical usefulness as biomarkers for ALS. Methods: In all, 104 consecutive patients referred with suspicion of ALS were prospectively included and were subsequently divided into 62 patients with motor neuron disease (MND) and 42 patient controls (ALS mimics) by clinical follow-up. T-SICI and A-SICI recorded in the first dorsal interosseus muscle (index test) were compared with recordings from 53 age-matched healthy controls. The reference standard was the Awaji criteria. Clinical scorings, conventional nerve conduction studies and electromyography were also performed on the patients. Results: Motor neuron disease patients had significantly reduced T-SICI and A-SICI compared with the healthy and patient control groups, which were similar. Sensitivity and specificity for discriminating MND patients from patient controls were high (areas under the receiver operating characteristic curves 0.762 and 0.810 for T-SICI and A-SICI respectively at 1-3.5 ms). Paradoxically, T-SICI was most reduced in MND patients with the fewest upper motor neuron (UMN) signs (Spearman ρ = 0.565, p = 4.3 × 10-6 ). Conclusions: Amplitude-based measure of cortical inhibition and T-SICI are both sensitive measures for the detection of cortical involvement in MND patients and may help early diagnosis of ALS, with T-SICI most abnormal before UMN signs have developed. The gradation in T-SICI from pathological facilitation in patients with minimal UMN signs to inhibition in those with the most UMN signs may be due to progressive degeneration of the subset of UMNs experiencing facilitation.John Wiley & Sons, Inc.Repositório da Universidade de LisboaTankisi, HaticeNielsen, Christina S.‐Z.Howells, JamesCengiz, BülentSamusyte, GintauteKoltzenburg, MartinBlicher, Jakob U.Møller, Anette T.Pugdahl, KirstenFuglsang‐Frederiksen, AndersCarvalho, MamedeBostock, Hugh2021-09-24T17:27:53Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49628engEur J Neurol. 2021 Sep;28(9):3030-30391351-510110.1111/ene.150101468-1331info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:53:34Zoai:repositorio.ul.pt:10451/49628Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:01:16.493233Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
title Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
spellingShingle Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
Tankisi, Hatice
Amyotrophic lateral sclerosis
Conventional TMS
Short-interval intracortical inhibition
Threshold tracking TMS
Transcranial magnetic stimulation
title_short Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
title_full Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
title_fullStr Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
title_full_unstemmed Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
title_sort Early diagnosis of amyotrophic lateral sclerosis by threshold tracking and conventional transcranial magnetic stimulation
author Tankisi, Hatice
author_facet Tankisi, Hatice
Nielsen, Christina S.‐Z.
Howells, James
Cengiz, Bülent
Samusyte, Gintaute
Koltzenburg, Martin
Blicher, Jakob U.
Møller, Anette T.
Pugdahl, Kirsten
Fuglsang‐Frederiksen, Anders
Carvalho, Mamede
Bostock, Hugh
author_role author
author2 Nielsen, Christina S.‐Z.
Howells, James
Cengiz, Bülent
Samusyte, Gintaute
Koltzenburg, Martin
Blicher, Jakob U.
Møller, Anette T.
Pugdahl, Kirsten
Fuglsang‐Frederiksen, Anders
Carvalho, Mamede
Bostock, Hugh
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Tankisi, Hatice
Nielsen, Christina S.‐Z.
Howells, James
Cengiz, Bülent
Samusyte, Gintaute
Koltzenburg, Martin
Blicher, Jakob U.
Møller, Anette T.
Pugdahl, Kirsten
Fuglsang‐Frederiksen, Anders
Carvalho, Mamede
Bostock, Hugh
dc.subject.por.fl_str_mv Amyotrophic lateral sclerosis
Conventional TMS
Short-interval intracortical inhibition
Threshold tracking TMS
Transcranial magnetic stimulation
topic Amyotrophic lateral sclerosis
Conventional TMS
Short-interval intracortical inhibition
Threshold tracking TMS
Transcranial magnetic stimulation
description © 2021 The Authors. European Journal of Neurology published by John Wiley & Sons Ltd on behalf of European Academy of Neurology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
publishDate 2021
dc.date.none.fl_str_mv 2021-09-24T17:27:53Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/49628
url http://hdl.handle.net/10451/49628
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Neurol. 2021 Sep;28(9):3030-3039
1351-5101
10.1111/ene.15010
1468-1331
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons, Inc.
publisher.none.fl_str_mv John Wiley & Sons, Inc.
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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