The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis

Detalhes bibliográficos
Autor(a) principal: Castro, José
Data de Publicação: 2023
Outros Autores: Swash, Michael, Carvalho, Mamede
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/56102
Resumo: © 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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spelling The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosisAmyotrophic lateral sclerosisCutaneous silent periodMotor neuron diseaseTranscranial magnetic stimulationUpper motor neuron© 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Objectives: We investigated the cutaneous silent period (CutSP) as a measure of upper motor neuron (UMN) dysfunction in amyotrophic lateral sclerosis. Methods: The onset latency, duration, and amount of EMG suppression of the CutSP were compared with clinical UMN signs in 24 patients with amyotrophic lateral sclerosis (ALS). UMN signs were quantified using a clinical index and transcranial magnetic stimulation (TMS). Central motor conduction time (CMCT), cortical motor threshold and motor evoked potential amplitudes were assessed as measures of UMN dysfunction. CutSP was studied in abductor digit minimi (ADM) and tibialis anterior (TA) EMG recordings following stimulation of the 5th finger and sural nerves respectively. Non-parametric tests and binomial logistic regression were applied to evaluate the data. Results: CutSP onset latency was increased in ALS patients, compared to healthy controls, both for ADM and TA muscles. In limbs with clinical UMN signs or abnormal TMS findings, the CutSP onset latency was particularly increased. There was a significant positive correlation between CutSP onset latency and the UMN score in both upper and lower limbs. In TA muscles there was also a negative correlation between CutSP onset latency and EMG suppression. The logistic regression model based on CutSP parameters correctly classified more than 70% of the cases regarding the presence of clinical signs of UMN lesion, in both upper and lower limbs. The results were not significant for TMS. Conclusion: We conclude that upper limb CutSP changes associates with UMN lesion in ALS. This neurophysiological measurement merits further investigation in ALS.This work was funded by the project “Spinal circuitry in Motor Neuron Disease: Changes in Spinal and Corticospinal Mechanisms in Amyotrophic Lateral Sclerosis and its variants” (sponsored by Biogen Inc)ElsevierRepositório da Universidade de LisboaCastro, JoséSwash, MichaelCarvalho, Mamede2023-02-01T15:34:28Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/56102engNeurophysiol Clin. 2023 Jan 28;53(4):1028430987-705310.1016/j.neucli.2022.1028431769-7131info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T17:03:27Zoai:repositorio.ul.pt:10451/56102Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:06:38.650277Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
title The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
spellingShingle The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
Castro, José
Amyotrophic lateral sclerosis
Cutaneous silent period
Motor neuron disease
Transcranial magnetic stimulation
Upper motor neuron
title_short The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
title_full The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
title_fullStr The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
title_full_unstemmed The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
title_sort The cutaneous silent period as a measure of upper motor neuron dysfunction in amyotrophic lateral sclerosis
author Castro, José
author_facet Castro, José
Swash, Michael
Carvalho, Mamede
author_role author
author2 Swash, Michael
Carvalho, Mamede
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Castro, José
Swash, Michael
Carvalho, Mamede
dc.subject.por.fl_str_mv Amyotrophic lateral sclerosis
Cutaneous silent period
Motor neuron disease
Transcranial magnetic stimulation
Upper motor neuron
topic Amyotrophic lateral sclerosis
Cutaneous silent period
Motor neuron disease
Transcranial magnetic stimulation
Upper motor neuron
description © 2022 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023-02-01T15:34:28Z
2023
2023-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/56102
url http://hdl.handle.net/10451/56102
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Neurophysiol Clin. 2023 Jan 28;53(4):102843
0987-7053
10.1016/j.neucli.2022.102843
1769-7131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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