A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study

Detalhes bibliográficos
Autor(a) principal: Pedroso de Lima, J
Data de Publicação: 2003
Outros Autores: Pedroso de Lima, JJ, Isidoro, I, Lapa, P
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.4/979
Resumo: A method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99mTc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characteristics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency.
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spelling A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative studyFígadoImagiologia com RadionuclídeosRadiofármacosA method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99mTc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characteristics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency.RIHUCPedroso de Lima, JPedroso de Lima, JJIsidoro, ILapa, P2011-01-27T12:36:35Z20032003-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.4/979engRev Esp Med Nucl. 2003 Jul-Aug;22(4):244-9.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-11T14:22:10Zoai:rihuc.huc.min-saude.pt:10400.4/979Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:03:32.734989Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
title A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
spellingShingle A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
Pedroso de Lima, J
Fígado
Imagiologia com Radionuclídeos
Radiofármacos
title_short A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
title_full A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
title_fullStr A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
title_full_unstemmed A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
title_sort A new method for quantification of hepatobiliary scintigraphy using 99mTc-mebrofenin. A comparative study
author Pedroso de Lima, J
author_facet Pedroso de Lima, J
Pedroso de Lima, JJ
Isidoro, I
Lapa, P
author_role author
author2 Pedroso de Lima, JJ
Isidoro, I
Lapa, P
author2_role author
author
author
dc.contributor.none.fl_str_mv RIHUC
dc.contributor.author.fl_str_mv Pedroso de Lima, J
Pedroso de Lima, JJ
Isidoro, I
Lapa, P
dc.subject.por.fl_str_mv Fígado
Imagiologia com Radionuclídeos
Radiofármacos
topic Fígado
Imagiologia com Radionuclídeos
Radiofármacos
description A method based upon the application of mathematical techniques of deconvolution on the classical compartmental model for the quantitative study of liver function from hepatobiliary scintigraphy using 99mTc-mebrofenin data is proposed. The theory in which the method is based upon is presented and a comparison with a published methodology of obtaining the hepatic extraction after scintigraphic sudies has been performed using the results on 36 rats studies obtained with the two methods. A highly significant correlation between the two techniques was verified. The characteristics of the two methodologies, the proposed one based upon a theoretical approach and the other one on an empirical approximation are discussed. Comments are made on the interest and limitations of the presented technique that may be an useful tool for the evaluation of hepatic insufficiency.
publishDate 2003
dc.date.none.fl_str_mv 2003
2003-01-01T00:00:00Z
2011-01-27T12:36:35Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.4/979
url http://hdl.handle.net/10400.4/979
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Rev Esp Med Nucl. 2003 Jul-Aug;22(4):244-9.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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