Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections

Detalhes bibliográficos
Autor(a) principal: Carneiro, Victor Alves
Data de Publicação: 2011
Outros Autores: Santos, Hélcio Silva dos, Arruda, Francisco Vassiliepe Sousa, Bandeira, Paulo Nogueira, Albuquerque, Maria Rose Jane Ribeiro, Pereira, Maria Olívia, Henriques, Mariana, Cavada, Benildo Sousa, Teixeira, Edson Holanda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/16646
Resumo: Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms
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spelling Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infectionsCasbane diterpeneBiofilm-associated infections controlNatural antimicrobialsBacteria and yeastScience & TechnologyCroton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganismsThis study was supported by FUNCAP and CNPq (Brazil) and by FCT (Portugal) through the project PTDC/SAU-ESA/64609/2006.MDPIUniversidade do MinhoCarneiro, Victor AlvesSantos, Hélcio Silva dosArruda, Francisco Vassiliepe SousaBandeira, Paulo NogueiraAlbuquerque, Maria Rose Jane RibeiroPereira, Maria OlíviaHenriques, MarianaCavada, Benildo SousaTeixeira, Edson Holanda2011-07-042011-07-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/16646eng1420-304910.3390/molecules1601019021193844info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:33:23Zoai:repositorium.sdum.uminho.pt:1822/16646Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:28:54.172437Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
title Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
spellingShingle Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
Carneiro, Victor Alves
Casbane diterpene
Biofilm-associated infections control
Natural antimicrobials
Bacteria and yeast
Science & Technology
title_short Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
title_full Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
title_fullStr Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
title_full_unstemmed Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
title_sort Casbane diterpene as a promising natural antimicrobial agent against biofilm-associated infections
author Carneiro, Victor Alves
author_facet Carneiro, Victor Alves
Santos, Hélcio Silva dos
Arruda, Francisco Vassiliepe Sousa
Bandeira, Paulo Nogueira
Albuquerque, Maria Rose Jane Ribeiro
Pereira, Maria Olívia
Henriques, Mariana
Cavada, Benildo Sousa
Teixeira, Edson Holanda
author_role author
author2 Santos, Hélcio Silva dos
Arruda, Francisco Vassiliepe Sousa
Bandeira, Paulo Nogueira
Albuquerque, Maria Rose Jane Ribeiro
Pereira, Maria Olívia
Henriques, Mariana
Cavada, Benildo Sousa
Teixeira, Edson Holanda
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Carneiro, Victor Alves
Santos, Hélcio Silva dos
Arruda, Francisco Vassiliepe Sousa
Bandeira, Paulo Nogueira
Albuquerque, Maria Rose Jane Ribeiro
Pereira, Maria Olívia
Henriques, Mariana
Cavada, Benildo Sousa
Teixeira, Edson Holanda
dc.subject.por.fl_str_mv Casbane diterpene
Biofilm-associated infections control
Natural antimicrobials
Bacteria and yeast
Science & Technology
topic Casbane diterpene
Biofilm-associated infections control
Natural antimicrobials
Bacteria and yeast
Science & Technology
description Croton nepetaefolius is a native plant from northeastern Brazil that belongs to the Euphorbiaceae family. The biological action of this plant has been extensively explored, being the secondary metabolites responsible for its properties alkaloids, diterpenes, and triterpenes. This study aimed to evaluate the ability of casbane diterpene (CD), isolated from the ethanolic extract of C. nepetaefolius, to inhibit microbial growth and biofilm formation of several clinical relevant species (bacteria and yeasts). It was found that CD possessed biocidal and biostatic activity against the majority of the species screened, with minimal active concentrations ranging between 125 and 500 µg/mL. In addition, it was observed that biofilm formation was inhibited even when the planktonic growth was not significantly affected. In conclusion, CD showed potential to be a natural tool for the treatment of diseases caused by different infectious microorganisms
publishDate 2011
dc.date.none.fl_str_mv 2011-07-04
2011-07-04T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/16646
url http://hdl.handle.net/1822/16646
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1420-3049
10.3390/molecules16010190
21193844
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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