The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia

Detalhes bibliográficos
Autor(a) principal: Kuil, Larissa de Melo
Data de Publicação: 2017
Outros Autores: Lorenzi, Adriana Tarla, Stein, Maíra Degiovani, Resende, Júlio César Possati, Antoniazzi, Márcio, Longatto Filho, Adhemar, Scapulatempo-Neto, Cristovam, Fregnani, José Humberto Tavares Guerreiro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/49003
Resumo: The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
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spelling The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial NeoplasiaSecondary preventionPapillomavirus infectionsCervical neoplasmsMolecular diagnostic techniquesSelf-collectionCiências Médicas::Medicina BásicaScience & TechnologyThe Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial NeoplasiaObjective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. Methods: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. The sample was divided into two aliquots: one for the cytological study and one for the molecular analysis of high-risk HPV. Results: Fifty-eight percent of the participants preferred to utilize self-collection as an alternative screening method. However, we noticed that the HPV positivity rate was significantly lower in self-collected samples when compared to those obtained using the conventional collection method (p = 0.035). The cytology tests of the samples obtained via self-collection were sensitive and had a positive predictive value and an area under the curve (AUC) that were significantly lower than those of the Pap test. However, the specificity and negative predictive value of these tests were similar. When compared with the HPV test, the self-collected samples demonstrated lower accuracy in predicting high-grade cervical intraepithelial neoplasia or worse, with a significantly lower sensitivity, positive predictive value, and AUC than the cervical Pap test samples. Conclusion: Self-collection by vaginal lavage is simple and well accepted by women. Due to its limitations, however, self-collection by lavage should be utilized with caution.info:eu-repo/semantics/publishedVersionKarger PublishersUniversidade do MinhoKuil, Larissa de MeloLorenzi, Adriana TarlaStein, Maíra DegiovaniResende, Júlio César PossatiAntoniazzi, MárcioLongatto Filho, AdhemarScapulatempo-Neto, CristovamFregnani, José Humberto Tavares Guerreiro2017-11-112017-11-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49003engde Melo Kuil, L., Lorenzi, A. T., Stein, M. D., Resende, J. C. P., Antoniazzi, M., Longatto-Filho, A., ... & Fregnani, J. H. T. G. (2017). The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytologica0001-55471938-265010.1159/00047733128564641https://www.karger.com/Article/Abstract/477331info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:47Zoai:repositorium.sdum.uminho.pt:1822/49003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:31.844171Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
title The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
spellingShingle The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
Kuil, Larissa de Melo
Secondary prevention
Papillomavirus infections
Cervical neoplasms
Molecular diagnostic techniques
Self-collection
Ciências Médicas::Medicina Básica
Science & Technology
title_short The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
title_full The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
title_fullStr The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
title_full_unstemmed The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
title_sort The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
author Kuil, Larissa de Melo
author_facet Kuil, Larissa de Melo
Lorenzi, Adriana Tarla
Stein, Maíra Degiovani
Resende, Júlio César Possati
Antoniazzi, Márcio
Longatto Filho, Adhemar
Scapulatempo-Neto, Cristovam
Fregnani, José Humberto Tavares Guerreiro
author_role author
author2 Lorenzi, Adriana Tarla
Stein, Maíra Degiovani
Resende, Júlio César Possati
Antoniazzi, Márcio
Longatto Filho, Adhemar
Scapulatempo-Neto, Cristovam
Fregnani, José Humberto Tavares Guerreiro
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Kuil, Larissa de Melo
Lorenzi, Adriana Tarla
Stein, Maíra Degiovani
Resende, Júlio César Possati
Antoniazzi, Márcio
Longatto Filho, Adhemar
Scapulatempo-Neto, Cristovam
Fregnani, José Humberto Tavares Guerreiro
dc.subject.por.fl_str_mv Secondary prevention
Papillomavirus infections
Cervical neoplasms
Molecular diagnostic techniques
Self-collection
Ciências Médicas::Medicina Básica
Science & Technology
topic Secondary prevention
Papillomavirus infections
Cervical neoplasms
Molecular diagnostic techniques
Self-collection
Ciências Médicas::Medicina Básica
Science & Technology
description The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
publishDate 2017
dc.date.none.fl_str_mv 2017-11-11
2017-11-11T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/49003
url http://hdl.handle.net/1822/49003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv de Melo Kuil, L., Lorenzi, A. T., Stein, M. D., Resende, J. C. P., Antoniazzi, M., Longatto-Filho, A., ... & Fregnani, J. H. T. G. (2017). The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytologica
0001-5547
1938-2650
10.1159/000477331
28564641
https://www.karger.com/Article/Abstract/477331
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger Publishers
publisher.none.fl_str_mv Karger Publishers
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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