The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/49003 |
Resumo: | The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
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7160 |
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The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial NeoplasiaSecondary preventionPapillomavirus infectionsCervical neoplasmsMolecular diagnostic techniquesSelf-collectionCiências Médicas::Medicina BásicaScience & TechnologyThe Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial NeoplasiaObjective: To compare the results of cervical cytology and high-risk HPV tests using samples obtained using two different collection modalities in a population of Brazilian women: self-collection (vaginal lavage) and cervical Pap testing. Methods: We enrolled 204 women who were aged 18-64 years and had previously obtained abnormal cervical cytology test results; 83.8% of them agreed to participate. The sample was divided into two aliquots: one for the cytological study and one for the molecular analysis of high-risk HPV. Results: Fifty-eight percent of the participants preferred to utilize self-collection as an alternative screening method. However, we noticed that the HPV positivity rate was significantly lower in self-collected samples when compared to those obtained using the conventional collection method (p = 0.035). The cytology tests of the samples obtained via self-collection were sensitive and had a positive predictive value and an area under the curve (AUC) that were significantly lower than those of the Pap test. However, the specificity and negative predictive value of these tests were similar. When compared with the HPV test, the self-collected samples demonstrated lower accuracy in predicting high-grade cervical intraepithelial neoplasia or worse, with a significantly lower sensitivity, positive predictive value, and AUC than the cervical Pap test samples. Conclusion: Self-collection by vaginal lavage is simple and well accepted by women. Due to its limitations, however, self-collection by lavage should be utilized with caution.info:eu-repo/semantics/publishedVersionKarger PublishersUniversidade do MinhoKuil, Larissa de MeloLorenzi, Adriana TarlaStein, Maíra DegiovaniResende, Júlio César PossatiAntoniazzi, MárcioLongatto Filho, AdhemarScapulatempo-Neto, CristovamFregnani, José Humberto Tavares Guerreiro2017-11-112017-11-11T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49003engde Melo Kuil, L., Lorenzi, A. T., Stein, M. D., Resende, J. C. P., Antoniazzi, M., Longatto-Filho, A., ... & Fregnani, J. H. T. G. (2017). The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytologica0001-55471938-265010.1159/00047733128564641https://www.karger.com/Article/Abstract/477331info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:34:47Zoai:repositorium.sdum.uminho.pt:1822/49003Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:30:31.844171Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
title |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
spellingShingle |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia Kuil, Larissa de Melo Secondary prevention Papillomavirus infections Cervical neoplasms Molecular diagnostic techniques Self-collection Ciências Médicas::Medicina Básica Science & Technology |
title_short |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
title_full |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
title_fullStr |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
title_full_unstemmed |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
title_sort |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
author |
Kuil, Larissa de Melo |
author_facet |
Kuil, Larissa de Melo Lorenzi, Adriana Tarla Stein, Maíra Degiovani Resende, Júlio César Possati Antoniazzi, Márcio Longatto Filho, Adhemar Scapulatempo-Neto, Cristovam Fregnani, José Humberto Tavares Guerreiro |
author_role |
author |
author2 |
Lorenzi, Adriana Tarla Stein, Maíra Degiovani Resende, Júlio César Possati Antoniazzi, Márcio Longatto Filho, Adhemar Scapulatempo-Neto, Cristovam Fregnani, José Humberto Tavares Guerreiro |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Kuil, Larissa de Melo Lorenzi, Adriana Tarla Stein, Maíra Degiovani Resende, Júlio César Possati Antoniazzi, Márcio Longatto Filho, Adhemar Scapulatempo-Neto, Cristovam Fregnani, José Humberto Tavares Guerreiro |
dc.subject.por.fl_str_mv |
Secondary prevention Papillomavirus infections Cervical neoplasms Molecular diagnostic techniques Self-collection Ciências Médicas::Medicina Básica Science & Technology |
topic |
Secondary prevention Papillomavirus infections Cervical neoplasms Molecular diagnostic techniques Self-collection Ciências Médicas::Medicina Básica Science & Technology |
description |
The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-11-11 2017-11-11T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/49003 |
url |
http://hdl.handle.net/1822/49003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
de Melo Kuil, L., Lorenzi, A. T., Stein, M. D., Resende, J. C. P., Antoniazzi, M., Longatto-Filho, A., ... & Fregnani, J. H. T. G. (2017). The Role of Self-Collection by Vaginal Lavage for the Detection of HPV and High-Grade Intraepithelial Neoplasia. Acta Cytologica 0001-5547 1938-2650 10.1159/000477331 28564641 https://www.karger.com/Article/Abstract/477331 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Karger Publishers |
publisher.none.fl_str_mv |
Karger Publishers |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799132809811460096 |