Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection

Detalhes bibliográficos
Autor(a) principal: Meira e Cruz, Miguel
Data de Publicação: 2020
Outros Autores: Miyazawa, Masaaki, Gozal, David
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/46892
Resumo: Copyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0
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spelling Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infectionCopyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiological agent of the pandemic coronavirus disease 2019 (COVID-19), is a newly found member of the Coronaviridae family, and is closely related to, albeit with important differences from, SARS-CoV. It enters human cells through the binding of surface spike (S) glycoprotein with angiotensin-converting enzyme 2 (ACE2). The distal S1 subunit of the S protein is responsible for receptor binding, while the transmembrane S2 subunit mediates fusion between the viral envelope and the target cell membrane following proteolytic cleavage by specific cellular enzymes such as transmembrane serine protease 2 for S protein priming. As it is likely that expression levels of ACE2 affect the efficiency of virus attachment and entry, as well as disease severity, and the interactions between viral S protein and ACE2 may directly cause lung injury, ACE2 may be a potential target of therapeutic and preventative interventions.European Respiratory SocietyRepositório da Universidade de LisboaMeira e Cruz, MiguelMiyazawa, MasaakiGozal, David2021-03-17T18:07:18Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46892engEur Respir J 2020; 55: 20010230903-193610.1183/13993003.01023-20201399-3003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:27Zoai:repositorio.ul.pt:10451/46892Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:58.794866Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
title Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
spellingShingle Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
Meira e Cruz, Miguel
title_short Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
title_full Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
title_fullStr Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
title_full_unstemmed Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
title_sort Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
author Meira e Cruz, Miguel
author_facet Meira e Cruz, Miguel
Miyazawa, Masaaki
Gozal, David
author_role author
author2 Miyazawa, Masaaki
Gozal, David
author2_role author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Meira e Cruz, Miguel
Miyazawa, Masaaki
Gozal, David
description Copyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-01-01T00:00:00Z
2021-03-17T18:07:18Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/46892
url http://hdl.handle.net/10451/46892
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur Respir J 2020; 55: 2001023
0903-1936
10.1183/13993003.01023-2020
1399-3003
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv European Respiratory Society
publisher.none.fl_str_mv European Respiratory Society
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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