Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/46892 |
Resumo: | Copyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 |
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Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infectionCopyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the aetiological agent of the pandemic coronavirus disease 2019 (COVID-19), is a newly found member of the Coronaviridae family, and is closely related to, albeit with important differences from, SARS-CoV. It enters human cells through the binding of surface spike (S) glycoprotein with angiotensin-converting enzyme 2 (ACE2). The distal S1 subunit of the S protein is responsible for receptor binding, while the transmembrane S2 subunit mediates fusion between the viral envelope and the target cell membrane following proteolytic cleavage by specific cellular enzymes such as transmembrane serine protease 2 for S protein priming. As it is likely that expression levels of ACE2 affect the efficiency of virus attachment and entry, as well as disease severity, and the interactions between viral S protein and ACE2 may directly cause lung injury, ACE2 may be a potential target of therapeutic and preventative interventions.European Respiratory SocietyRepositório da Universidade de LisboaMeira e Cruz, MiguelMiyazawa, MasaakiGozal, David2021-03-17T18:07:18Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/46892engEur Respir J 2020; 55: 20010230903-193610.1183/13993003.01023-20201399-3003info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:49:27Zoai:repositorio.ul.pt:10451/46892Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:58:58.794866Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
title |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
spellingShingle |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection Meira e Cruz, Miguel |
title_short |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
title_full |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
title_fullStr |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
title_full_unstemmed |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
title_sort |
Putative contributions of circadian clock and sleep in the context of SARS-CoV-2 infection |
author |
Meira e Cruz, Miguel |
author_facet |
Meira e Cruz, Miguel Miyazawa, Masaaki Gozal, David |
author_role |
author |
author2 |
Miyazawa, Masaaki Gozal, David |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Meira e Cruz, Miguel Miyazawa, Masaaki Gozal, David |
description |
Copyright © ERS 2020. This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0 |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020 2020-01-01T00:00:00Z 2021-03-17T18:07:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/46892 |
url |
http://hdl.handle.net/10451/46892 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Eur Respir J 2020; 55: 2001023 0903-1936 10.1183/13993003.01023-2020 1399-3003 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
European Respiratory Society |
publisher.none.fl_str_mv |
European Respiratory Society |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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