Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma

Detalhes bibliográficos
Autor(a) principal: Rodrigues, Paulo
Data de Publicação: 1997
Outros Autores: Fernandes, Cândida, Machado, João, Cardoso, Orlando, Pereira, Fátima, Botelho, Aida, Afonso, Ana, Proença, Rui
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://revista.spmi.pt/index.php/rpmi/article/view/2231
Resumo: Adverse cutaneous reactions to drugs are frequent (2 to 3 percent of hospitalized patients); although most are not severe, afew are related with high ra­tes of morbility and mortality. Rapid recognition of severe reactions is essencial, such as Stevens-john­ son syndrome, toxic epidermal, necrolysis and hyper­ sensitivity syndrome. The drugs most often respon­sible for the hypersensitivity syndrome are anticon­vulsants, sulphonamides and allopurinol Hypersen­ sitivity syndrome induced by drugs in rare instan­ces present clinical characteristics and even a histo­logic picture indistinguishable from true cutaneous lymphoma. ln these cases the differentiation betwe­en the two clinical entities although difficult, is very important due to the natural therapeutic implicati­ons. The authors present a 51-years old patient with rapid installation of high fever and erythroderma. The histologic findings of the cutaneous and lymphode biopsies were of cutaneous T-cell lymphoma with specific lymph node involvement. However, we were informed that the patient had been medicated with allopurino two weeks before the symptoms. The clinical and analytical characteristics and the clini­cal evolution, confirmed the diagnosis of allopurinol hypersensitivity syndrome.
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spelling Allopurinol hypersensivity syndrome presenting as cutaneous lymphomaSíndrome de hipersensibilidade ao alopurinol simulando linfoma cutâneosíndrome de hipersensibilidadepseudo-linfoma cutâneoalopurinolhypersensitivity syndromecutaneous pseudofymphomaallopurinolAdverse cutaneous reactions to drugs are frequent (2 to 3 percent of hospitalized patients); although most are not severe, afew are related with high ra­tes of morbility and mortality. Rapid recognition of severe reactions is essencial, such as Stevens-john­ son syndrome, toxic epidermal, necrolysis and hyper­ sensitivity syndrome. The drugs most often respon­sible for the hypersensitivity syndrome are anticon­vulsants, sulphonamides and allopurinol Hypersen­ sitivity syndrome induced by drugs in rare instan­ces present clinical characteristics and even a histo­logic picture indistinguishable from true cutaneous lymphoma. ln these cases the differentiation betwe­en the two clinical entities although difficult, is very important due to the natural therapeutic implicati­ons. The authors present a 51-years old patient with rapid installation of high fever and erythroderma. The histologic findings of the cutaneous and lymphode biopsies were of cutaneous T-cell lymphoma with specific lymph node involvement. However, we were informed that the patient had been medicated with allopurino two weeks before the symptoms. The clinical and analytical characteristics and the clini­cal evolution, confirmed the diagnosis of allopurinol hypersensitivity syndrome.As reacções cutâneas secundárias às drogas são frequentes (em 2 a 3% dos doentes hospitalizados); embora na maioria sem gravidade, num pequeno número de casos podem atingir elevada morbilida­ de e mortalidade. É por isso essencial o rápido reconhecimento das reaccões mais graves, como por exemplo síndrome de Stevens-johnson, necrólise epi­dérmica tóxica ou síndrome de hipersensibilidade. Neste último as drogas mais frequentemente respon­sáveis são os antiepilépticos, sulfonamidas e alopu­rinol. Os síndromes de hipersensibilidade a fárma­cos assumem raramente características clínicas e sobretudo histológicas quase indistinguíveis dos ver­dadeiros linfomas cutâneos. Nestes casos a diferen­ciacão entre estas duas entidades, embora difícil, é muito importante pelas naturais implicações tera­pêuticas. A este propósito os autores descrevem o caso clínico de um doente de 51 anos, com febre elevada de início abrupto e eritrodermia, em que o exame his­tológico das biópsias cutânea e ganglionar foi de linfoma cutâneo de células T com envolvimento ganglionar especifico. Veio no entanto a apurar-se que o doente tinha sido medicado com alopurinol duas semanas antes do início da febre. As características clínico-laboratoriais e a evolução vieram a compro­var o diagnóstico de síndrome de hipersensibilidade­ ao alopurinol.Sociedade Portuguesa de Medicina Interna1997-09-30info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://revista.spmi.pt/index.php/rpmi/article/view/2231Internal Medicine; Vol. 4 No. 3 (1997): Julho/ Setembro; 182-186Medicina Interna; Vol. 4 N.º 3 (1997): Julho/ Setembro; 182-1862183-99800872-671Xreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPporhttps://revista.spmi.pt/index.php/rpmi/article/view/2231https://revista.spmi.pt/index.php/rpmi/article/view/2231/1607Rodrigues, PauloFernandes, CândidaMachado, JoãoCardoso, OrlandoPereira, FátimaBotelho, AidaAfonso, AnaProença, Ruiinfo:eu-repo/semantics/openAccess2023-08-19T06:11:35Zoai:oai.revista.spmi.pt:article/2231Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:27:19.250888Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
Síndrome de hipersensibilidade ao alopurinol simulando linfoma cutâneo
title Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
spellingShingle Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
Rodrigues, Paulo
síndrome de hipersensibilidade
pseudo-linfoma cutâneo
alopurinol
hypersensitivity syndrome
cutaneous pseudofymphoma
allopurinol
title_short Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
title_full Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
title_fullStr Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
title_full_unstemmed Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
title_sort Allopurinol hypersensivity syndrome presenting as cutaneous lymphoma
author Rodrigues, Paulo
author_facet Rodrigues, Paulo
Fernandes, Cândida
Machado, João
Cardoso, Orlando
Pereira, Fátima
Botelho, Aida
Afonso, Ana
Proença, Rui
author_role author
author2 Fernandes, Cândida
Machado, João
Cardoso, Orlando
Pereira, Fátima
Botelho, Aida
Afonso, Ana
Proença, Rui
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rodrigues, Paulo
Fernandes, Cândida
Machado, João
Cardoso, Orlando
Pereira, Fátima
Botelho, Aida
Afonso, Ana
Proença, Rui
dc.subject.por.fl_str_mv síndrome de hipersensibilidade
pseudo-linfoma cutâneo
alopurinol
hypersensitivity syndrome
cutaneous pseudofymphoma
allopurinol
topic síndrome de hipersensibilidade
pseudo-linfoma cutâneo
alopurinol
hypersensitivity syndrome
cutaneous pseudofymphoma
allopurinol
description Adverse cutaneous reactions to drugs are frequent (2 to 3 percent of hospitalized patients); although most are not severe, afew are related with high ra­tes of morbility and mortality. Rapid recognition of severe reactions is essencial, such as Stevens-john­ son syndrome, toxic epidermal, necrolysis and hyper­ sensitivity syndrome. The drugs most often respon­sible for the hypersensitivity syndrome are anticon­vulsants, sulphonamides and allopurinol Hypersen­ sitivity syndrome induced by drugs in rare instan­ces present clinical characteristics and even a histo­logic picture indistinguishable from true cutaneous lymphoma. ln these cases the differentiation betwe­en the two clinical entities although difficult, is very important due to the natural therapeutic implicati­ons. The authors present a 51-years old patient with rapid installation of high fever and erythroderma. The histologic findings of the cutaneous and lymphode biopsies were of cutaneous T-cell lymphoma with specific lymph node involvement. However, we were informed that the patient had been medicated with allopurino two weeks before the symptoms. The clinical and analytical characteristics and the clini­cal evolution, confirmed the diagnosis of allopurinol hypersensitivity syndrome.
publishDate 1997
dc.date.none.fl_str_mv 1997-09-30
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dc.identifier.uri.fl_str_mv https://revista.spmi.pt/index.php/rpmi/article/view/2231
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dc.language.iso.fl_str_mv por
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dc.relation.none.fl_str_mv https://revista.spmi.pt/index.php/rpmi/article/view/2231
https://revista.spmi.pt/index.php/rpmi/article/view/2231/1607
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dc.publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
publisher.none.fl_str_mv Sociedade Portuguesa de Medicina Interna
dc.source.none.fl_str_mv Internal Medicine; Vol. 4 No. 3 (1997): Julho/ Setembro; 182-186
Medicina Interna; Vol. 4 N.º 3 (1997): Julho/ Setembro; 182-186
2183-9980
0872-671X
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