Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/106537 https://doi.org/10.3390/pharmaceutics12070649 |
Resumo: | Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications. |
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Silica-Based Gene Delivery Systems: From Design to Therapeutic Applicationssilica-based vectorshybrid silica nanosystemssilane chemistrytargeted gene deliverystimuli-responsive releasegene therapyAdvances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications.MDPI2020-07-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/106537http://hdl.handle.net/10316/106537https://doi.org/10.3390/pharmaceutics12070649eng1999-4923Carvalho, Ana MariaCordeiro, Rosemeyre A.Faneca, Henriqueinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-04-10T08:43:41Zoai:estudogeral.uc.pt:10316/106537Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:22:58.875353Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
title |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
spellingShingle |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications Carvalho, Ana Maria silica-based vectors hybrid silica nanosystems silane chemistry targeted gene delivery stimuli-responsive release gene therapy |
title_short |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
title_full |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
title_fullStr |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
title_full_unstemmed |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
title_sort |
Silica-Based Gene Delivery Systems: From Design to Therapeutic Applications |
author |
Carvalho, Ana Maria |
author_facet |
Carvalho, Ana Maria Cordeiro, Rosemeyre A. Faneca, Henrique |
author_role |
author |
author2 |
Cordeiro, Rosemeyre A. Faneca, Henrique |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Carvalho, Ana Maria Cordeiro, Rosemeyre A. Faneca, Henrique |
dc.subject.por.fl_str_mv |
silica-based vectors hybrid silica nanosystems silane chemistry targeted gene delivery stimuli-responsive release gene therapy |
topic |
silica-based vectors hybrid silica nanosystems silane chemistry targeted gene delivery stimuli-responsive release gene therapy |
description |
Advances in gene therapy have been foreshadowing its potential for the treatment of a vast range of diseases involving genetic malfunctioning. However, its therapeutic efficiency and successful outcome are highly dependent on the development of the ideal gene delivery system. On that matter, silica-based vectors have diverted some attention from viral and other types of non-viral vectors due to their increased safety, easily modifiable structure and surface, high stability, and cost-effectiveness. The versatility of silane chemistry and the combination of silica with other materials, such as polymers, lipids, or inorganic particles, has resulted in the development of carriers with great loading capacities, ability to effectively protect and bind genetic material, targeted delivery, and stimuli-responsive release of cargos. Promising results have been obtained both in vitro and in vivo using these nanosystems as multifunctional platforms in different potential therapeutic areas, such as cancer or brain therapies, sometimes combined with imaging functions. Herein, the current advances in silica-based systems designed for gene therapy are reviewed, including their main properties, fabrication methods, surface modifications, and potential therapeutic applications. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/106537 http://hdl.handle.net/10316/106537 https://doi.org/10.3390/pharmaceutics12070649 |
url |
http://hdl.handle.net/10316/106537 https://doi.org/10.3390/pharmaceutics12070649 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1999-4923 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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