Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review

Detalhes bibliográficos
Autor(a) principal: Moreira, André
Data de Publicação: 2016
Outros Autores: Dias, Diana Rodrigues, Correia, Ilídio Joaquim Sobreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/4687
Resumo: The application of nanocarriers as selective drug delivery platforms, as imaging or as diagnostic agents has been evaluated in several studies in the area of biomedicine, namely for cancer therapy. Such systems have the potential to perform a controlled and site-specific delivery of therapeutic agents leading to a reduction of side effects and, ultimately, to an improved therapeutic outcome. Among the different nanocarriers developed so far, mesoporous silica nanoparticles have attracted the attention of the scientific community for being applied as drug delivery systems that are capable of controlling, both in space and time, the drug release. In this review, the modifications performed, so far, on mesoporous silica nanoparticles to imprint them a stimulus responsive behavior (namely, pH, redox potential, adenosine triphosphate, enzyme or temperature) in order to allow their application in cancer therapy are highlighted.
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spelling Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A reviewCancer therapyDrug deliveryMesoporous silica nanoparticlesStimuli-responsive behaviorThe application of nanocarriers as selective drug delivery platforms, as imaging or as diagnostic agents has been evaluated in several studies in the area of biomedicine, namely for cancer therapy. Such systems have the potential to perform a controlled and site-specific delivery of therapeutic agents leading to a reduction of side effects and, ultimately, to an improved therapeutic outcome. Among the different nanocarriers developed so far, mesoporous silica nanoparticles have attracted the attention of the scientific community for being applied as drug delivery systems that are capable of controlling, both in space and time, the drug release. In this review, the modifications performed, so far, on mesoporous silica nanoparticles to imprint them a stimulus responsive behavior (namely, pH, redox potential, adenosine triphosphate, enzyme or temperature) in order to allow their application in cancer therapy are highlighted.ElsevieruBibliorumMoreira, AndréDias, Diana RodriguesCorreia, Ilídio Joaquim Sobreira2018-03-21T14:19:45Z2016-08-312016-08-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/4687engMoreira, A. F., Dias, D. R., e Correia, I. J. (2016) “Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review.” Microporous and Mesoporous Materials, Vol.236, pp.141-15710.1016/j.micromeso.2016.08.038metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:41:57Zoai:ubibliorum.ubi.pt:10400.6/4687Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:45:44.465942Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
title Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
spellingShingle Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
Moreira, André
Cancer therapy
Drug delivery
Mesoporous silica nanoparticles
Stimuli-responsive behavior
title_short Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
title_full Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
title_fullStr Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
title_full_unstemmed Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
title_sort Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review
author Moreira, André
author_facet Moreira, André
Dias, Diana Rodrigues
Correia, Ilídio Joaquim Sobreira
author_role author
author2 Dias, Diana Rodrigues
Correia, Ilídio Joaquim Sobreira
author2_role author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Moreira, André
Dias, Diana Rodrigues
Correia, Ilídio Joaquim Sobreira
dc.subject.por.fl_str_mv Cancer therapy
Drug delivery
Mesoporous silica nanoparticles
Stimuli-responsive behavior
topic Cancer therapy
Drug delivery
Mesoporous silica nanoparticles
Stimuli-responsive behavior
description The application of nanocarriers as selective drug delivery platforms, as imaging or as diagnostic agents has been evaluated in several studies in the area of biomedicine, namely for cancer therapy. Such systems have the potential to perform a controlled and site-specific delivery of therapeutic agents leading to a reduction of side effects and, ultimately, to an improved therapeutic outcome. Among the different nanocarriers developed so far, mesoporous silica nanoparticles have attracted the attention of the scientific community for being applied as drug delivery systems that are capable of controlling, both in space and time, the drug release. In this review, the modifications performed, so far, on mesoporous silica nanoparticles to imprint them a stimulus responsive behavior (namely, pH, redox potential, adenosine triphosphate, enzyme or temperature) in order to allow their application in cancer therapy are highlighted.
publishDate 2016
dc.date.none.fl_str_mv 2016-08-31
2016-08-31T00:00:00Z
2018-03-21T14:19:45Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/4687
url http://hdl.handle.net/10400.6/4687
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Moreira, A. F., Dias, D. R., e Correia, I. J. (2016) “Stimuli-responsive mesoporous silica nanoparticles for cancer therapy: A review.” Microporous and Mesoporous Materials, Vol.236, pp.141-157
10.1016/j.micromeso.2016.08.038
dc.rights.driver.fl_str_mv metadata only access
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rights_invalid_str_mv metadata only access
eu_rights_str_mv openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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