Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome

Detalhes bibliográficos
Autor(a) principal: Arede, Pedro Bruno
Data de Publicação: 2021
Outros Autores: Cordeiro, Miguel, Guedes, Marta
Tipo de documento: Relatório
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.48560/rspo.24120
Resumo: Tubulointerstitial Nephritis and Uveitis (TINU) syndrome is characterized by bilateral anterior uveitis and idiopathic tubulointerstitial nephritis. A 37-year-old female with bilateral anterior uveitis, malaise and fever was evaluated at the Ophthalmology Emergency department. Laboratory investigation revealed an elevated C-re- active protein, a raised erythrocyte sedimentation ratio and a sub-nephrotic proteinuria. Patient was then referred for Nephrology assessment and a renal biopsy showed diffuse tubulointerstitialnephritis. TINU syndrome was assumed. Bilateral anterior uveitis resolved after one week of topi- cal steroid therapy. This case highlights an under recognized syndrome, occurring in young patients with asymp- tomatic mild renal disease and chronic or recurrent anterior uveitis. It is important to be aware of this clinical entity since a prompt diagnosis and appropriate treatment can avoid poor renal and visual outcomes.
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spelling Tubulointerstitial Nephritis and Uveitis (TINU) SyndromeSíndrome Nefrite Túbulo Intersticial Aguda e Uveíte (TINU)Comunicações Curtas e Imagens em OftalmologiaTubulointerstitial Nephritis and Uveitis (TINU) syndrome is characterized by bilateral anterior uveitis and idiopathic tubulointerstitial nephritis. A 37-year-old female with bilateral anterior uveitis, malaise and fever was evaluated at the Ophthalmology Emergency department. Laboratory investigation revealed an elevated C-re- active protein, a raised erythrocyte sedimentation ratio and a sub-nephrotic proteinuria. Patient was then referred for Nephrology assessment and a renal biopsy showed diffuse tubulointerstitialnephritis. TINU syndrome was assumed. Bilateral anterior uveitis resolved after one week of topi- cal steroid therapy. This case highlights an under recognized syndrome, occurring in young patients with asymp- tomatic mild renal disease and chronic or recurrent anterior uveitis. It is important to be aware of this clinical entity since a prompt diagnosis and appropriate treatment can avoid poor renal and visual outcomes.A síndrome nefrite túbulo-intersticial e uveíte (NTIU) é caracterizada por uveíte anterior bi- lateral e nefrite tubulointersticial idiopática. Este trabalho descreve o caso de uma mulher de 37 anos que recorreu à urgência de oftalmologia com uveíte anterior bilateral, mal-estar geral e febre. A investigação laboratorial revelou elevação da proteína C reativa e velocidade de sedimentação , bem como, proteinúria subnefrótica. A paciente foi encaminhada para avaliação nefrológica e biópsia renal que mostrou nefrite tubulointersticial difusa. A síndrome NTIU foi diagnosticada. A bilateral resolveu após uma semana de corticoterapia tópica. Este caso destaca uma síndrome pouco reconhecida, ocorrendo em pacientes jovens com doen- ça renal leve assintomática e uveíte anterior crónica e recorrente. É importante manter suspeição clínica desta entidade, pois um diagnóstico imediato e tratamento adequado podem evitar mau prognóstico visual e renal.Ajnet2021-03-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/reporthttps://doi.org/10.48560/rspo.24120eng1646-69501646-6950Arede, Pedro BrunoCordeiro, MiguelGuedes, Martainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-22T17:06:15Zoai:ojs.revistas.rcaap.pt:article/24120Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:01:46.455707Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
Síndrome Nefrite Túbulo Intersticial Aguda e Uveíte (TINU)
title Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
spellingShingle Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
Arede, Pedro Bruno
Comunicações Curtas e Imagens em Oftalmologia
title_short Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
title_full Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
title_fullStr Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
title_full_unstemmed Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
title_sort Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
author Arede, Pedro Bruno
author_facet Arede, Pedro Bruno
Cordeiro, Miguel
Guedes, Marta
author_role author
author2 Cordeiro, Miguel
Guedes, Marta
author2_role author
author
dc.contributor.author.fl_str_mv Arede, Pedro Bruno
Cordeiro, Miguel
Guedes, Marta
dc.subject.por.fl_str_mv Comunicações Curtas e Imagens em Oftalmologia
topic Comunicações Curtas e Imagens em Oftalmologia
description Tubulointerstitial Nephritis and Uveitis (TINU) syndrome is characterized by bilateral anterior uveitis and idiopathic tubulointerstitial nephritis. A 37-year-old female with bilateral anterior uveitis, malaise and fever was evaluated at the Ophthalmology Emergency department. Laboratory investigation revealed an elevated C-re- active protein, a raised erythrocyte sedimentation ratio and a sub-nephrotic proteinuria. Patient was then referred for Nephrology assessment and a renal biopsy showed diffuse tubulointerstitialnephritis. TINU syndrome was assumed. Bilateral anterior uveitis resolved after one week of topi- cal steroid therapy. This case highlights an under recognized syndrome, occurring in young patients with asymp- tomatic mild renal disease and chronic or recurrent anterior uveitis. It is important to be aware of this clinical entity since a prompt diagnosis and appropriate treatment can avoid poor renal and visual outcomes.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-31T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/report
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status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.48560/rspo.24120
url https://doi.org/10.48560/rspo.24120
dc.language.iso.fl_str_mv eng
language eng
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1646-6950
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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