Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | https://doi.org/10.29021/spdv.75.3.822 |
Resumo: | Merkel cell carcinoma is an aggressive skin neoplasm affecting predominantly older or immunosuppressed patients. The progression to metastatic disease is frequent while spontaneous regression is quite uncommon. Chronic sun exposure and infection by Merkel cell polyomavirus are known etiopathogenic factors. An 89-year-old female was observed with a locally advanced Merkel cell carcinoma of the left nasal ala. Lymph node metastases in left submandibular region were clinically apparent and confirmed by fine-needle aspiration. A solitary metastasis in the liver was identified by positron-emission tomography/computed tomography with (68)Ga-DOTATOC. While she was waiting for palliative radiation therapy, the patient experienced a complete clinical remission of the primary tumor and regional lymph nodes metastases occurring after 6 weeks. A liver ultrasonography disclosed remission of the liver metastasis as well. The spontaneous remission is rarely reported in medical literature. As far as we know, this is the first report in Portugal. The underlying mechanism of the spontaneous remission remains unknown, although theoretically it can be explained by the development of an efficient immune response against the tumor. |
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Advanced Merkel Cell Carcinoma: A New Case of Spontaneous RegressionCarcinoma Avançado de Células de Merkel: Um Novo Caso de Regressão EspontâneaAgedCarcinomaMerkel CellNeoplasm RegressionSpontaneousCarcinoma de Células de MerkelIdosoRegressão Neoplásica EspontâneaMerkel cell carcinoma is an aggressive skin neoplasm affecting predominantly older or immunosuppressed patients. The progression to metastatic disease is frequent while spontaneous regression is quite uncommon. Chronic sun exposure and infection by Merkel cell polyomavirus are known etiopathogenic factors. An 89-year-old female was observed with a locally advanced Merkel cell carcinoma of the left nasal ala. Lymph node metastases in left submandibular region were clinically apparent and confirmed by fine-needle aspiration. A solitary metastasis in the liver was identified by positron-emission tomography/computed tomography with (68)Ga-DOTATOC. While she was waiting for palliative radiation therapy, the patient experienced a complete clinical remission of the primary tumor and regional lymph nodes metastases occurring after 6 weeks. A liver ultrasonography disclosed remission of the liver metastasis as well. The spontaneous remission is rarely reported in medical literature. As far as we know, this is the first report in Portugal. The underlying mechanism of the spontaneous remission remains unknown, although theoretically it can be explained by the development of an efficient immune response against the tumor.O carcinoma de células de Merkel é uma neoplasia cutânea agressiva que afecta predominantemente indivíduos idosos ou imunodeprimidos. A progressão para doença metastática é frequente, enquanto a regressão espontãnea é bastante rara. A exposição crónica à radiação solar e a infecção pelo poliomavírus das células de Merkel são reconhecidos factores etiopatogénicos. Uma mulher de 89 anos foi observada com um carcinoma de células de Merkel localmente avançado na asa esquerda do nariz. Tinha doença ganglionar metastática na região submandibular clinicamente evidente, confirmada por punção aspirativa com agulha fina. Uma metástase hepatica isolada foi detectada por estudo tomográfico por emissão de positrões com (68)Ga-DOTATOC. Enquanto aguardava por radioterapia paliativa, observou-se regressão do tumor primário e das metástases ganglionares, clinicamente completa ao fim de 6 semanas. Uma ecografia hepática demonstrou regressão concomitante da metástase hepatica. Os relatos de regressão espontânea de carcinoma de Merkel são muito escassos na literatura. Após a revisão realizada pelos autores, este é o primeiro caso descrito em Portugal. O mecanismo subjacente à remissão espontânea é desconhecido, embora possa ser teioricamente explicado pelo desenvolvimento de uma resposta immune eficaz contra o tumor.Sociedade Portuguesa de Dermatologia e Venereologia2018-01-22T00:00:00Zjournal articleinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.29021/spdv.75.3.822oai:ojs.revista.spdv.com.pt:article/822Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 3 (2017): Julho - Setembro; 301-304Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 3 (2017): Julho - Setembro; 301-3042182-24092182-2395reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAPenghttps://revista.spdv.com.pt/index.php/spdv/article/view/822https://doi.org/10.29021/spdv.75.3.822https://revista.spdv.com.pt/index.php/spdv/article/view/822/517Guiote, VictoriaCunha, FernandaPinho, AndréBrinca, AnaVieira, Ricardoinfo:eu-repo/semantics/openAccess2022-10-06T12:35:05Zoai:ojs.revista.spdv.com.pt:article/822Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:11:04.167508Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression Carcinoma Avançado de Células de Merkel: Um Novo Caso de Regressão Espontânea |
title |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
spellingShingle |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression Guiote, Victoria Aged Carcinoma Merkel Cell Neoplasm Regression Spontaneous Carcinoma de Células de Merkel Idoso Regressão Neoplásica Espontânea |
title_short |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
title_full |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
title_fullStr |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
title_full_unstemmed |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
title_sort |
Advanced Merkel Cell Carcinoma: A New Case of Spontaneous Regression |
author |
Guiote, Victoria |
author_facet |
Guiote, Victoria Cunha, Fernanda Pinho, André Brinca, Ana Vieira, Ricardo |
author_role |
author |
author2 |
Cunha, Fernanda Pinho, André Brinca, Ana Vieira, Ricardo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Guiote, Victoria Cunha, Fernanda Pinho, André Brinca, Ana Vieira, Ricardo |
dc.subject.por.fl_str_mv |
Aged Carcinoma Merkel Cell Neoplasm Regression Spontaneous Carcinoma de Células de Merkel Idoso Regressão Neoplásica Espontânea |
topic |
Aged Carcinoma Merkel Cell Neoplasm Regression Spontaneous Carcinoma de Células de Merkel Idoso Regressão Neoplásica Espontânea |
description |
Merkel cell carcinoma is an aggressive skin neoplasm affecting predominantly older or immunosuppressed patients. The progression to metastatic disease is frequent while spontaneous regression is quite uncommon. Chronic sun exposure and infection by Merkel cell polyomavirus are known etiopathogenic factors. An 89-year-old female was observed with a locally advanced Merkel cell carcinoma of the left nasal ala. Lymph node metastases in left submandibular region were clinically apparent and confirmed by fine-needle aspiration. A solitary metastasis in the liver was identified by positron-emission tomography/computed tomography with (68)Ga-DOTATOC. While she was waiting for palliative radiation therapy, the patient experienced a complete clinical remission of the primary tumor and regional lymph nodes metastases occurring after 6 weeks. A liver ultrasonography disclosed remission of the liver metastasis as well. The spontaneous remission is rarely reported in medical literature. As far as we know, this is the first report in Portugal. The underlying mechanism of the spontaneous remission remains unknown, although theoretically it can be explained by the development of an efficient immune response against the tumor. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-22T00:00:00Z |
dc.type.driver.fl_str_mv |
journal article info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.29021/spdv.75.3.822 oai:ojs.revista.spdv.com.pt:article/822 |
url |
https://doi.org/10.29021/spdv.75.3.822 |
identifier_str_mv |
oai:ojs.revista.spdv.com.pt:article/822 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://revista.spdv.com.pt/index.php/spdv/article/view/822 https://doi.org/10.29021/spdv.75.3.822 https://revista.spdv.com.pt/index.php/spdv/article/view/822/517 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
publisher.none.fl_str_mv |
Sociedade Portuguesa de Dermatologia e Venereologia |
dc.source.none.fl_str_mv |
Journal of the Portuguese Society of Dermatology and Venereology; Vol 75 No 3 (2017): Julho - Setembro; 301-304 Revista da Sociedade Portuguesa de Dermatologia e Venereologia; v. 75 n. 3 (2017): Julho - Setembro; 301-304 2182-2409 2182-2395 reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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