Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis
| Autor(a) principal: | |
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| Data de Publicação: | 2009 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/17638 |
Resumo: | The Journal of Rheumatology Copyright © 2009. All rights reserved. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritisJuvenile idiopathic arthritis−308 genotypesTumor necrosis factor-α promoter polymorphismsPrognosisThe Journal of Rheumatology Copyright © 2009. All rights reserved.OBJECTIVE: Considering the relevance of tumor necrosis factor-α (TNF-α) in the pathophysiology of juvenile idiopathic arthritis (JIA), it is likely that polymorphisms in its promoter area may be relevant in disease susceptibility and activity. We investigated if clinical measures of JIA activity and TNF-α serum concentrations were associated with TNF-α –308 genotypes. METHODS: Portuguese patients with JIA in 5 pediatric rheumatology centers were recruited consecutively, along with a control group of healthy subjects. Demographic and clinical data and blood samples were collected from each patient. DNA was extracted for analysis of TNF-α gene promoter polymorphisms at position –308 by restriction fragment-length polymorphism. RESULTS: One hundred fourteen patients and 117 controls were evaluated; 57% of patients presented the oligoarticular subtype, 25% the polyarticular subtype, 8% the systemic subtype, and 9% had enthesitis-related arthritis and 5% psoriatic arthritis. Twenty-four percent of the patients presented the –308 GA/AA genotypes and 76% the –308 GG genotype, similar to findings in controls. Patients with the –308 GA/AA genotype had higher degree of functional impairment, erythrocyte sedimentation rate, 100-mm visual analog scale score for disease activity, and TNF-α levels compared to those with the –308 GG genotype. CONCLUSION: TNF-α –308 GA/AA genotypes were found to be related to higher inflammatory activity and worse measures of disease activity in Portuguese patients with JIA. They were not associated with susceptibility to JIA.Supported by a research grant from AstraZeneca and Faculdade de Medicina da Universidade de Lisboa.Journal of Rheumatology Publishing Company LimitedRepositório da Universidade de LisboaMourão, Ana FilipaCaetano-Lopes, JoanaCosta, PaulaCanhao, HelenaSantos, Maria JoséPinto, PatríciaBrito, IvaNicola, PauloCavaleiro, JoãoTeles, JoséSousa, ArturGomes, José MeloBranco, JaimeCosta, José Teixeira daPedro, João GomesQueiroz, Mário Viana deFonseca, João Eurico2015-03-09T11:56:45Z20092009-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/17638engJ Rheumatol 2009;36;837-8420315-162X10.3899/jrheum.080615metadata only accessinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:03:23Zoai:repositorio.ul.pt:10451/17638Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:37:27.587392Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| title |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| spellingShingle |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis Mourão, Ana Filipa Juvenile idiopathic arthritis −308 genotypes Tumor necrosis factor-α promoter polymorphisms Prognosis |
| title_short |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| title_full |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| title_fullStr |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| title_full_unstemmed |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| title_sort |
Tumor necrosis factor-α–308 genotypes influence inflammatory activity and TNF-α serum concentrations in children with juvenile idiopathic arthritis |
| author |
Mourão, Ana Filipa |
| author_facet |
Mourão, Ana Filipa Caetano-Lopes, Joana Costa, Paula Canhao, Helena Santos, Maria José Pinto, Patrícia Brito, Iva Nicola, Paulo Cavaleiro, João Teles, José Sousa, Artur Gomes, José Melo Branco, Jaime Costa, José Teixeira da Pedro, João Gomes Queiroz, Mário Viana de Fonseca, João Eurico |
| author_role |
author |
| author2 |
Caetano-Lopes, Joana Costa, Paula Canhao, Helena Santos, Maria José Pinto, Patrícia Brito, Iva Nicola, Paulo Cavaleiro, João Teles, José Sousa, Artur Gomes, José Melo Branco, Jaime Costa, José Teixeira da Pedro, João Gomes Queiroz, Mário Viana de Fonseca, João Eurico |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Mourão, Ana Filipa Caetano-Lopes, Joana Costa, Paula Canhao, Helena Santos, Maria José Pinto, Patrícia Brito, Iva Nicola, Paulo Cavaleiro, João Teles, José Sousa, Artur Gomes, José Melo Branco, Jaime Costa, José Teixeira da Pedro, João Gomes Queiroz, Mário Viana de Fonseca, João Eurico |
| dc.subject.por.fl_str_mv |
Juvenile idiopathic arthritis −308 genotypes Tumor necrosis factor-α promoter polymorphisms Prognosis |
| topic |
Juvenile idiopathic arthritis −308 genotypes Tumor necrosis factor-α promoter polymorphisms Prognosis |
| description |
The Journal of Rheumatology Copyright © 2009. All rights reserved. |
| publishDate |
2009 |
| dc.date.none.fl_str_mv |
2009 2009-01-01T00:00:00Z 2015-03-09T11:56:45Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/17638 |
| url |
http://hdl.handle.net/10451/17638 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
J Rheumatol 2009;36;837-842 0315-162X 10.3899/jrheum.080615 |
| dc.rights.driver.fl_str_mv |
metadata only access info:eu-repo/semantics/openAccess |
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metadata only access |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Journal of Rheumatology Publishing Company Limited |
| publisher.none.fl_str_mv |
Journal of Rheumatology Publishing Company Limited |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134272211124224 |