Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/15405 |
Resumo: | Polydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering. |
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Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applicationsPolydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering.The authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT), COMPETE and FEDER through the Projects PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013, PTDC/QEQ-FTT/4287/2014 and fellowship SFRH/BD/89077/2012. Partial support from the spanish Ministry of Science and Education (Grant No. DPI2013-46485), Junta de Extremadura (Grant No. GR10047), and “la Caixa” Foundation (predoctoral grant) is gratefully acknowledged too. Finally, we thank Jos e M. Montanero for his helpful suggestions and discussion on the results.Biblioteca Digital do IPBMuñoz-Sánchez, Beatriz N.Silva, Filipa SilvaPinho, DianaVega, E.J.Lima, Rui A.2018-01-31T10:00:00Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15405engMuñoz-Sánchez, B. N.; Silva, S. F.; Pinho, D.; Vega, E. J.; Lima, R. (2016). Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications. Biomicrofluidics. ISSN 1932-1058. 10, p. 1-111932-105810.1063/1.4943007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:36:00Zoai:bibliotecadigital.ipb.pt:10198/15405Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:00.288197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
title |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
spellingShingle |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications Muñoz-Sánchez, Beatriz N. |
title_short |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
title_full |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
title_fullStr |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
title_full_unstemmed |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
title_sort |
Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications |
author |
Muñoz-Sánchez, Beatriz N. |
author_facet |
Muñoz-Sánchez, Beatriz N. Silva, Filipa Silva Pinho, Diana Vega, E.J. Lima, Rui A. |
author_role |
author |
author2 |
Silva, Filipa Silva Pinho, Diana Vega, E.J. Lima, Rui A. |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Muñoz-Sánchez, Beatriz N. Silva, Filipa Silva Pinho, Diana Vega, E.J. Lima, Rui A. |
description |
Polydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 2016-01-01T00:00:00Z 2018-01-31T10:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/15405 |
url |
http://hdl.handle.net/10198/15405 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Muñoz-Sánchez, B. N.; Silva, S. F.; Pinho, D.; Vega, E. J.; Lima, R. (2016). Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications. Biomicrofluidics. ISSN 1932-1058. 10, p. 1-11 1932-1058 10.1063/1.4943007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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