Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications

Detalhes bibliográficos
Autor(a) principal: Muñoz-Sánchez, Beatriz N.
Data de Publicação: 2016
Outros Autores: Silva, Filipa Silva, Pinho, Diana, Vega, E.J., Lima, Rui A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/15405
Resumo: Polydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering.
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spelling Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applicationsPolydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering.The authors acknowledge the financial support provided by Fundação para a Ciência e a Tecnologia (FCT), COMPETE and FEDER through the Projects PTDC/SAU-ENB/116929/2010, EXPL/EMS-SIS/2215/2013, PTDC/QEQ-FTT/4287/2014 and fellowship SFRH/BD/89077/2012. Partial support from the spanish Ministry of Science and Education (Grant No. DPI2013-46485), Junta de Extremadura (Grant No. GR10047), and “la Caixa” Foundation (predoctoral grant) is gratefully acknowledged too. Finally, we thank Jos e M. Montanero for his helpful suggestions and discussion on the results.Biblioteca Digital do IPBMuñoz-Sánchez, Beatriz N.Silva, Filipa SilvaPinho, DianaVega, E.J.Lima, Rui A.2018-01-31T10:00:00Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/15405engMuñoz-Sánchez, B. N.; Silva, S. F.; Pinho, D.; Vega, E. J.; Lima, R. (2016). Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications. Biomicrofluidics. ISSN 1932-1058. 10, p. 1-111932-105810.1063/1.4943007info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:36:00Zoai:bibliotecadigital.ipb.pt:10198/15405Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:00.288197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
title Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
spellingShingle Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
Muñoz-Sánchez, Beatriz N.
title_short Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
title_full Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
title_fullStr Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
title_full_unstemmed Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
title_sort Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications
author Muñoz-Sánchez, Beatriz N.
author_facet Muñoz-Sánchez, Beatriz N.
Silva, Filipa Silva
Pinho, Diana
Vega, E.J.
Lima, Rui A.
author_role author
author2 Silva, Filipa Silva
Pinho, Diana
Vega, E.J.
Lima, Rui A.
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Muñoz-Sánchez, Beatriz N.
Silva, Filipa Silva
Pinho, Diana
Vega, E.J.
Lima, Rui A.
description Polydimethylsiloxane (PDMS), due to its remarkable properties, is one of the most widely used polymers in many industrial and medical applications. In this work, a technique based on a flow focusing technique is used to produce PDMS spherical particles with sizes of a few microns. PDMS precursor is injected through a hypodermic needle to form a film/reservoir over the needle's outer surface. This film flows towards the needle tip until a liquid ligament is steadily ejected thanks to the action of a coflowing viscous liquid stream. The outcome is a capillary jet which breaks up into PDMS precursor droplets due to the growth of capillary waves producing a micrometer emulsion. The PDMS liquid droplets in the solution are thermally cured into solid microparticles. The size distribution of the particles is analyzed before and after curing, showing an acceptable degree of monodispersity. The PDMS liquid droplets suffer shrinkage while curing. These microparticles can be used in very varied technological fields, such as biomedicine, biotechnology, pharmacy, and industrial engineering.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-01-01T00:00:00Z
2018-01-31T10:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/15405
url http://hdl.handle.net/10198/15405
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Muñoz-Sánchez, B. N.; Silva, S. F.; Pinho, D.; Vega, E. J.; Lima, R. (2016). Generation of micro-sized PDMS particles by a flow focusing technique for biomicrofluidics applications. Biomicrofluidics. ISSN 1932-1058. 10, p. 1-11
1932-1058
10.1063/1.4943007
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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