Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | https://doi.org/10.1371/journal.pone.0130347 |
Resumo: | WOS:000358154400018 |
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Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilateriansInsights from Anopheles mosquitoesEcology, Evolution, Behavior and SystematicsInsect ScienceSDG 3 - Good Health and Well-beingWOS:000358154400018Allatostatin type A receptors (AST-ARs) are a group of G-protein coupled receptors activated by members of the FGL-amide (AST-A) peptide family that inhibit food intake and development in arthropods. Despite their physiological importance the evolution of the AST-A system is poorly described and relatively few receptors have been isolated and functionally characterised in insects. The present study provides a comprehensive analysis of the origin and comparative evolution of the AST-A system. To determine how evolution and feeding modified the function of AST-AR the duplicate receptors in Anopheles mosquitoes, were characterised. Phylogeny and gene synteny suggested that invertebrate AST-A receptors and peptide genes shared a common evolutionary origin with KISS/GAL receptors and ligands. AST-ARs and KISSR emerged from a common gene ancestor after the divergence of GALRs in the bilaterian genome. In arthropods, the AST-A system evolved through lineage-specific events and the maintenance of two receptors in the flies and mosquitoes (Diptera) was the result of a gene duplication event. Speciation of Anophelesmosquitoes affected receptor gene organisation and characterisation of AST-AR duplicates (GPRALS1 and 2) revealed that in common with other insects, the mosquito receptors were activated by insect AST-A peptides and the iCa iCa2+-signalling pathway was stimulated. GPRALS1 and 2 were expressed mainly in mosquito midgut and ovaries and transcript abundance of both receptors was modified by feeding. A blood meal strongly up-regulated expression of both GPRALS in the midgut (p <0.05) compared to glucose fed females. Based on the results we hypothesise that the AST-A system in insects shared a common origin with the vertebrate KISS system and may also share a common function as an integrator of metabolism and reproduction. Highlights: AST-A and KISS/GAL receptors and ligands shared common ancestry prior to the protostome-deuterostome divergence. Phylogeny and gene synteny revealed that AST-AR and KISSR emerged after GALR gene divergence. AST-AR genes were present in the hemichordates but were lost from the chordates. In protostomes, AST-ARs persisted and evolved through lineage-specific events and duplicated in the arthropod radiation. Diptera acquired and maintained functionally divergent duplicate AST-AR genes.Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)RUNFelix, Rute C.Trindade, MarlenePires, Isa R PFonseca, Vera G.Martins, Rute S.Silveira, HenriquePower, Deborah M.Cardoso, João C R2018-05-14T22:01:10Z2015-07-022015-07-02T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1371/journal.pone.0130347eng1932-6203PURE: 1179189http://www.scopus.com/inward/record.url?scp=84940434889&partnerID=8YFLogxKhttps://doi.org/10.1371/journal.pone.0130347info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:20:27Zoai:run.unl.pt:10362/36918Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:41.907926Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians Insights from Anopheles mosquitoes |
| title |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| spellingShingle |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians Felix, Rute C. Ecology, Evolution, Behavior and Systematics Insect Science SDG 3 - Good Health and Well-being |
| title_short |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| title_full |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| title_fullStr |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| title_full_unstemmed |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| title_sort |
Unravelling the evolution of the allatostatin-type A, KISS and galanin peptide-receptor gene families in bilaterians |
| author |
Felix, Rute C. |
| author_facet |
Felix, Rute C. Trindade, Marlene Pires, Isa R P Fonseca, Vera G. Martins, Rute S. Silveira, Henrique Power, Deborah M. Cardoso, João C R |
| author_role |
author |
| author2 |
Trindade, Marlene Pires, Isa R P Fonseca, Vera G. Martins, Rute S. Silveira, Henrique Power, Deborah M. Cardoso, João C R |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Vector borne diseases and pathogens (VBD) Global Health and Tropical Medicine (GHTM) RUN |
| dc.contributor.author.fl_str_mv |
Felix, Rute C. Trindade, Marlene Pires, Isa R P Fonseca, Vera G. Martins, Rute S. Silveira, Henrique Power, Deborah M. Cardoso, João C R |
| dc.subject.por.fl_str_mv |
Ecology, Evolution, Behavior and Systematics Insect Science SDG 3 - Good Health and Well-being |
| topic |
Ecology, Evolution, Behavior and Systematics Insect Science SDG 3 - Good Health and Well-being |
| description |
WOS:000358154400018 |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015-07-02 2015-07-02T00:00:00Z 2018-05-14T22:01:10Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://doi.org/10.1371/journal.pone.0130347 |
| url |
https://doi.org/10.1371/journal.pone.0130347 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1932-6203 PURE: 1179189 http://www.scopus.com/inward/record.url?scp=84940434889&partnerID=8YFLogxK https://doi.org/10.1371/journal.pone.0130347 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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