Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study

Detalhes bibliográficos
Autor(a) principal: Silvestre, Joana
Data de Publicação: 2014
Outros Autores: Rebanda, Jorge, Lourenҫo, Carlos, Povoa, Pedro
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/145652
Resumo: Publisher Copyright: © 2014 Silvestre et al.; licensee BioMed Central Ltd.
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spelling Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot studyBiomarkersC-reactive proteinColorectal surgeryProcalcitoninSurgical infectionsInfectious DiseasesSDG 3 - Good Health and Well-beingPublisher Copyright: © 2014 Silvestre et al.; licensee BioMed Central Ltd.Background: Colorectal surgery is associated with postoperative infectious complications in up to 40% of cases, but the diagnosis of these complications is frequently misleading, delaying its resolution. Several biomarkers have been shown to be useful in infection diagnosis.Methods: We conducted a single-centre, prospective, observational study segregating patients submitted to elective colorectal surgery with primary anastomosis, CRP and PCT were measured daily. We compared infected and non-infected patients. Results: From October 2009 to June 2011, a total of 50 patients were included. Twenty-one patients developed infection. PCT and CRP before surgery were equally low in patients with or without postoperative infectious complications. After surgery, both PCT and CRP increased markedly. CRP time-course from the day of surgery onwards was significantly different in infected and non-infected patients (P = 0.001) whereas, PCT time-course was almost parallel in both groups (P = 0.866). Multiple comparisons between infected and non-infected patients from 5 th to 9 th postoperative days (POD) were performed and CRP concentration was significantly different (P < 0.01, Bonferroni correction), on the 6 th , 7 th and 8 th POD. A CRP concentration > 5.0 mg/dl at the D6 was predictive of infection with a sensitivity of 85% and a specificity of 62% (positive likelihood ratio 2.2, negative likelihood ratio 0.2). Conclusions: After a major elective surgical insult both CRP and PCT serum levels increased independently of the presence of infection. Besides serum CRP time-course showed to be useful in the early detection of an infectious complication whereas PCT was unhelpful.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSilvestre, JoanaRebanda, JorgeLourenҫo, CarlosPovoa, Pedro2022-11-18T22:13:59Z2014-08-162014-08-16T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/145652eng2374-4235PURE: 47804534https://doi.org/10.1186/1471-2334-14-444info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:15Zoai:run.unl.pt:10362/145652Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:12.236121Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
title Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
spellingShingle Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
Silvestre, Joana
Biomarkers
C-reactive protein
Colorectal surgery
Procalcitonin
Surgical infections
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
title_full Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
title_fullStr Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
title_full_unstemmed Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
title_sort Diagnostic accuracy of C-reactive protein and procalcitonin in the early detection of infection after elective colorectal surgery - a pilot study
author Silvestre, Joana
author_facet Silvestre, Joana
Rebanda, Jorge
Lourenҫo, Carlos
Povoa, Pedro
author_role author
author2 Rebanda, Jorge
Lourenҫo, Carlos
Povoa, Pedro
author2_role author
author
author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Silvestre, Joana
Rebanda, Jorge
Lourenҫo, Carlos
Povoa, Pedro
dc.subject.por.fl_str_mv Biomarkers
C-reactive protein
Colorectal surgery
Procalcitonin
Surgical infections
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Biomarkers
C-reactive protein
Colorectal surgery
Procalcitonin
Surgical infections
Infectious Diseases
SDG 3 - Good Health and Well-being
description Publisher Copyright: © 2014 Silvestre et al.; licensee BioMed Central Ltd.
publishDate 2014
dc.date.none.fl_str_mv 2014-08-16
2014-08-16T00:00:00Z
2022-11-18T22:13:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145652
url http://hdl.handle.net/10362/145652
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2374-4235
PURE: 47804534
https://doi.org/10.1186/1471-2334-14-444
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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