Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex

Detalhes bibliográficos
Autor(a) principal: Salústio, Paulo
Data de Publicação: 2010
Outros Autores: Marques, Helena, Costa, Paulo, Pinto, João
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/3853
Resumo: NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30.
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spelling Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complexb-CyclodextrinCapsuleCompactionDissolutionIbuprofenMinitabletNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30.Mixtures containing ibuprofen (IB) complexed with b-cyclodextrin (bCD) obtained by two complexation methods [suspension/solution (with water removed by air stream, spray- and freeze-drying) and kneading technique] were processed into pharmaceutical dosage forms (minitablets and capsules). Powders (IB, bCD and IBbCD) were characterized for moisture content, densities (true and bulk), angle of repose and Carr’s index, X-ray and NMR. From physical mixtures and IBbCD complexes without other excipients were prepared 2.5-mm-diameter minitablets and capsules. Minitablets were characterized for the energy of compaction, tensile strength, friability, density and IB release (at pH 1.0 and 7.2), whereby capsules were characterized for IB release. The results from the release of IB were analyzed using different parameters, namely, the similarity factor (f2), the dissolution efficiency (DE) and the amounts released at a certain time (30, 60 and 180 min) and compared statistically (a = 0.05). The release of IB from the minitablets showed no dependency on the amount of water used in the formation of the complexes. Differences were due to the compaction force used or the presence of a shell for the capsules. The differences observed were mostly due to the characteristics of the particles (dependent on the method considered on the formation of the complexes) and neither to the dosage form nor to the complex of the IB.ElsevierRepositório da Universidade de LisboaSalústio, PauloMarques, HelenaCosta, PauloPinto, João2011-08-02T13:36:31Z2010-12-302010-12-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/3853engEur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 300939-6411http://dx.doi.org/10.1016/j.ejpb.2010.12.022info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T15:44:09Zoai:repositorio.ul.pt:10451/3853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:29:28.810982Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
title Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
spellingShingle Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
Salústio, Paulo
b-Cyclodextrin
Capsule
Compaction
Dissolution
Ibuprofen
Minitablet
title_short Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
title_full Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
title_fullStr Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
title_full_unstemmed Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
title_sort Comparison of ibuprofen release from minitablets and capsules containing ibuprofen: β-Cyclodextrin complex
author Salústio, Paulo
author_facet Salústio, Paulo
Marques, Helena
Costa, Paulo
Pinto, João
author_role author
author2 Marques, Helena
Costa, Paulo
Pinto, João
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Salústio, Paulo
Marques, Helena
Costa, Paulo
Pinto, João
dc.subject.por.fl_str_mv b-Cyclodextrin
Capsule
Compaction
Dissolution
Ibuprofen
Minitablet
topic b-Cyclodextrin
Capsule
Compaction
Dissolution
Ibuprofen
Minitablet
description NOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30.
publishDate 2010
dc.date.none.fl_str_mv 2010-12-30
2010-12-30T00:00:00Z
2011-08-02T13:36:31Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/3853
url http://hdl.handle.net/10451/3853
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Eur J Pharm Biopharm. 2011 May;78(1):58-66. Epub 2010 Dec 30
0939-6411
http://dx.doi.org/10.1016/j.ejpb.2010.12.022
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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