Influence of the powders mixing process in the preparation of ibuprofen compounding capsules

• Autor(a) principal: Rosa, Maiane
• Data de Publicação: 2011
• Outros Autores: Flores, Fernanda Cramer, Beck, Ruy Carlos Ruver, Adams, Andréa Inês Horn, Silva, Cristiane de Bona da
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/2271
• topic: Capsules; Ibuprofen; Mixture.; Cápsulas; Ibuprofeno; Mistura.

The aim of this research was to evaluate de influence of the powder mixture process in the compounding of ibuprofen capsules. The mixing of powder was obtained in an automated mixer or manual (in plastic bags), the last one to simulate the procedures adopted in pharmacy compounding. After determination of the optimum mixing time, ibuprofen capsules were prepared (40 capsules/lot, 3 lots), with 100 or 200 mg of drug. The following tests were done to access the quality of capsules: medium weight, assay and uniformity of dosage units. Differences were observed between the two mixing process, especially for the capsules of lowest dosage (100 mg). In this case, the capsules prepared by manual mixture do not met the requirements of uniformity of dosage units. It was not observed differences between the mixing methods in the case of the capsules of 200 mg.