Mercury levels and neurotoxic potential of house dust extracts
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo de conferência |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/27615 |
Resumo: | The quality of the indoor environment is affected by a set of factors that include, among others, the presence of environmental contaminants. These contaminants are potentially toxic and can negatively affect the health of the inhabitants. Therefore, their study is fundamental, especially considering that in Western societies about 90% of the time is spent inside what has been called the “built environment”. The evaluation of the indoor environment contamination has been increasingly performed using dust. This matrix acts as a reservoir and repository of chemicals that are simultaneously protected from the degradation processes occurring naturally in the external environment. Available studies are mainly based on chemical analyzes that do not allow to evaluate the toxicity in an integrated way, making the implementation of toxicological tests an imperative. In this work, we evaluated the levels of mercury, a well-known neurotoxicant, in house dust extracts collected under the framework of the 6x60x6 case study. The cytotoxic potential of these dust extracts were also analyzed in the dopaminergic neural cell line N27. The obtained results disclose a moderate neurotoxic potential of the different dust extracts analyzed and a statistically significant correlation between cell viability and mercury concentrations (p<0.05, r=0.900). |
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Mercury levels and neurotoxic potential of house dust extractsThe quality of the indoor environment is affected by a set of factors that include, among others, the presence of environmental contaminants. These contaminants are potentially toxic and can negatively affect the health of the inhabitants. Therefore, their study is fundamental, especially considering that in Western societies about 90% of the time is spent inside what has been called the “built environment”. The evaluation of the indoor environment contamination has been increasingly performed using dust. This matrix acts as a reservoir and repository of chemicals that are simultaneously protected from the degradation processes occurring naturally in the external environment. Available studies are mainly based on chemical analyzes that do not allow to evaluate the toxicity in an integrated way, making the implementation of toxicological tests an imperative. In this work, we evaluated the levels of mercury, a well-known neurotoxicant, in house dust extracts collected under the framework of the 6x60x6 case study. The cytotoxic potential of these dust extracts were also analyzed in the dopaminergic neural cell line N27. The obtained results disclose a moderate neurotoxic potential of the different dust extracts analyzed and a statistically significant correlation between cell viability and mercury concentrations (p<0.05, r=0.900).2020-03-02T15:36:42Z2020-03-022019-11-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjecthttp://hdl.handle.net/10174/27615http://hdl.handle.net/10174/27615engBarros R, Sousa ACA, Nepomuceno M, Lanzinha JCG, Cristovão AC, Pastorinho MR (2019) Mercury levels and neurotoxic potential of house dust extracts. PTIM 2019, 3rd International Caparica Conference on Pollutant Toxic Ions and Molecules, 4-7 November 2019, Caparica, Portugal, p. 192, ISBN 978-989-54470-3-9 (Excellent Poster Presentation Prize)naonaosimndndndndndrpastorinho@uevora.pt553Barros, RSousa, Ana CatarinaNepomuceno, MLanzinha, JCGCristovão, ACPastorinho, M. Ramiroinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:23:08Zoai:dspace.uevora.pt:10174/27615Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:17:37.019503Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Mercury levels and neurotoxic potential of house dust extracts |
title |
Mercury levels and neurotoxic potential of house dust extracts |
spellingShingle |
Mercury levels and neurotoxic potential of house dust extracts Barros, R |
title_short |
Mercury levels and neurotoxic potential of house dust extracts |
title_full |
Mercury levels and neurotoxic potential of house dust extracts |
title_fullStr |
Mercury levels and neurotoxic potential of house dust extracts |
title_full_unstemmed |
Mercury levels and neurotoxic potential of house dust extracts |
title_sort |
Mercury levels and neurotoxic potential of house dust extracts |
author |
Barros, R |
author_facet |
Barros, R Sousa, Ana Catarina Nepomuceno, M Lanzinha, JCG Cristovão, AC Pastorinho, M. Ramiro |
author_role |
author |
author2 |
Sousa, Ana Catarina Nepomuceno, M Lanzinha, JCG Cristovão, AC Pastorinho, M. Ramiro |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Barros, R Sousa, Ana Catarina Nepomuceno, M Lanzinha, JCG Cristovão, AC Pastorinho, M. Ramiro |
description |
The quality of the indoor environment is affected by a set of factors that include, among others, the presence of environmental contaminants. These contaminants are potentially toxic and can negatively affect the health of the inhabitants. Therefore, their study is fundamental, especially considering that in Western societies about 90% of the time is spent inside what has been called the “built environment”. The evaluation of the indoor environment contamination has been increasingly performed using dust. This matrix acts as a reservoir and repository of chemicals that are simultaneously protected from the degradation processes occurring naturally in the external environment. Available studies are mainly based on chemical analyzes that do not allow to evaluate the toxicity in an integrated way, making the implementation of toxicological tests an imperative. In this work, we evaluated the levels of mercury, a well-known neurotoxicant, in house dust extracts collected under the framework of the 6x60x6 case study. The cytotoxic potential of these dust extracts were also analyzed in the dopaminergic neural cell line N27. The obtained results disclose a moderate neurotoxic potential of the different dust extracts analyzed and a statistically significant correlation between cell viability and mercury concentrations (p<0.05, r=0.900). |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-11-01T00:00:00Z 2020-03-02T15:36:42Z 2020-03-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/conferenceObject |
format |
conferenceObject |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/27615 http://hdl.handle.net/10174/27615 |
url |
http://hdl.handle.net/10174/27615 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Barros R, Sousa ACA, Nepomuceno M, Lanzinha JCG, Cristovão AC, Pastorinho MR (2019) Mercury levels and neurotoxic potential of house dust extracts. PTIM 2019, 3rd International Caparica Conference on Pollutant Toxic Ions and Molecules, 4-7 November 2019, Caparica, Portugal, p. 192, ISBN 978-989-54470-3-9 (Excellent Poster Presentation Prize) nao nao sim nd nd nd nd nd rpastorinho@uevora.pt 553 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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