First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique

Detalhes bibliográficos
Autor(a) principal: Carimo, Awa Abdul
Data de Publicação: 2018
Outros Autores: Gudo, Eduardo Samo, Maueia, Cremildo, Mabunda, Nédio, Chambal, Lúcia, Vubil, Adolfo, Flora, Ana, Antunes, Francisco, Bhatt, Nilesh
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/30412
Resumo: © 2018 Carimo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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spelling First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique© 2018 Carimo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.BACKGROUND: The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. OBJECTIVES: This study was conducted with the aim to investigate the prevalence of OBI and frequency of isolated hepatitis B core antibody (anti-HBc alone) among antiretroviral (ART) naïve HIV-positive patients in Mozambique. METHODS: A cross-sectional study was conducted in two health facilities within Maputo city. All ART-naive HIV seropositive patients attending outpatient clinics between June and October 2012 were consecutively enrolled. Blood samples were drawn from each participant and used for serological measurement of HBV surface antigen (HBsAg), antibodies against HBV surface antigen (anti-HBs) and antibodies against core antigen (anti-HBc) using ELISA. Quantification of HBV DNA was performed by real time PCR. A questionnaire was used to obtain demographics and clinical data. RESULTS: Of the 518 ART-naive HIV-positive subjects enrolled in the study, 90.9% (471/518) were HBsAg negative. Among HBsAg negative, 45.2% (213/471) had isolated anti-HBc antibodies, and the frequency of OBI among patients with anti-HBc alone was 8.3% (17/206). OBI was not correlated either with CD4+ T cells count or transaminases levels. A total of 11.8% of patients with OBI presented elevated HBV DNA level. Frequency of individuals with APRI score > 2 and FIB-4 score > 3.25 was higher in patients with OBI as compared not exposed, immune and anti-HBc alone patients. CONCLUSION: Our data demonstrate for the first time that OBI is prevalent among HIV patients in Mozambique, and will be missed using the commonly available serological assays that measures HBsAg.This work was supported by Ministry of Health of Mozambique, which participated in study design, data collection and analysis, and the decision to publish and the preparation of the manuscript. The funds were received by NB and ESG. Associação para Investigação e Desenvolvimento da Faculdade de Medicina, Lisbon, Portugal who had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. It was a part of the master thesis in emerging infectious diseases scholarship.Public Library of ScienceRepositório da Universidade de LisboaCarimo, Awa AbdulGudo, Eduardo SamoMaueia, CremildoMabunda, NédioChambal, LúciaVubil, AdolfoFlora, AnaAntunes, FranciscoBhatt, Nilesh2018-01-11T14:51:51Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/30412engPLoS ONE 13(1): e0190775.1932-620310.1371/journal.pone.0190775info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:23:15Zoai:repositorio.ul.pt:10451/30412Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:46:09.742831Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
title First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
spellingShingle First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
Carimo, Awa Abdul
title_short First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
title_full First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
title_fullStr First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
title_full_unstemmed First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
title_sort First report of occult hepatitis B infection among ART naïve HIV seropositive individuals in Maputo, Mozambique
author Carimo, Awa Abdul
author_facet Carimo, Awa Abdul
Gudo, Eduardo Samo
Maueia, Cremildo
Mabunda, Nédio
Chambal, Lúcia
Vubil, Adolfo
Flora, Ana
Antunes, Francisco
Bhatt, Nilesh
author_role author
author2 Gudo, Eduardo Samo
Maueia, Cremildo
Mabunda, Nédio
Chambal, Lúcia
Vubil, Adolfo
Flora, Ana
Antunes, Francisco
Bhatt, Nilesh
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carimo, Awa Abdul
Gudo, Eduardo Samo
Maueia, Cremildo
Mabunda, Nédio
Chambal, Lúcia
Vubil, Adolfo
Flora, Ana
Antunes, Francisco
Bhatt, Nilesh
description © 2018 Carimo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-11T14:51:51Z
2018
2018-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/30412
url http://hdl.handle.net/10451/30412
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS ONE 13(1): e0190775.
1932-6203
10.1371/journal.pone.0190775
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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