TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival

Detalhes bibliográficos
Autor(a) principal: Menino, João Filipe
Data de Publicação: 2013
Outros Autores: Saraiva, Margarida, Alves, Ana G. Gomes, Lobo-Silva, Diogo, Sturme, Mark H. J., Gomes, Jéssica Angélica Rezende, Saraiva, Ana Laura, Goldman, Gustavo H., Cunha, Cristina, Carvalho, Agostinho, Romani, Luigina, Pedrosa, Jorge, Castro, António Gil, Rodrigues, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/25192
Resumo: Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear.
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spelling TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survivalScience & TechnologyBackground: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear.J.F. Menino was supported by a grant from Fundacao para a Ciencia e Tecnologia (FCT), Portugal (SFRH/BD/33446/2008). This work was supported by a grant from FCT (PTDC/BIA-MIC/108309/2008). M. Saraiva is a Ciencia 2007 fellow and M. Sturme is a Ciencia 2008 fellow. We would also like to thank FAPESP (Fundacao para Amparo a Pesquisa do Estado de Sao Paulo) and CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) for financial support. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Public Library of Science (PLOS)Universidade do MinhoMenino, João FilipeSaraiva, MargaridaAlves, Ana G. GomesLobo-Silva, DiogoSturme, Mark H. J.Gomes, Jéssica Angélica RezendeSaraiva, Ana LauraGoldman, Gustavo H.Cunha, CristinaCarvalho, AgostinhoRomani, LuiginaPedrosa, JorgeCastro, António GilRodrigues, Fernando2013-072013-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/25192eng1935-273510.1371/journal.pntd.0002317http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002317info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:49:46Zoai:repositorium.sdum.uminho.pt:1822/25192Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:48:19.787105Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
title TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
spellingShingle TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
Menino, João Filipe
Science & Technology
title_short TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
title_full TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
title_fullStr TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
title_full_unstemmed TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
title_sort TLR9 activation dampens the early inflammatory response to paracoccidioides brasiliensis, Impacting host survival
author Menino, João Filipe
author_facet Menino, João Filipe
Saraiva, Margarida
Alves, Ana G. Gomes
Lobo-Silva, Diogo
Sturme, Mark H. J.
Gomes, Jéssica Angélica Rezende
Saraiva, Ana Laura
Goldman, Gustavo H.
Cunha, Cristina
Carvalho, Agostinho
Romani, Luigina
Pedrosa, Jorge
Castro, António Gil
Rodrigues, Fernando
author_role author
author2 Saraiva, Margarida
Alves, Ana G. Gomes
Lobo-Silva, Diogo
Sturme, Mark H. J.
Gomes, Jéssica Angélica Rezende
Saraiva, Ana Laura
Goldman, Gustavo H.
Cunha, Cristina
Carvalho, Agostinho
Romani, Luigina
Pedrosa, Jorge
Castro, António Gil
Rodrigues, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Menino, João Filipe
Saraiva, Margarida
Alves, Ana G. Gomes
Lobo-Silva, Diogo
Sturme, Mark H. J.
Gomes, Jéssica Angélica Rezende
Saraiva, Ana Laura
Goldman, Gustavo H.
Cunha, Cristina
Carvalho, Agostinho
Romani, Luigina
Pedrosa, Jorge
Castro, António Gil
Rodrigues, Fernando
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description Background: Paracoccidioides brasiliensis causes paracoccidioidomycosis, one of the most prevalent systemic mycosis in Latin America. Thus, understanding the characteristics of the protective immune response to P. brasiliensis is of interest, as it may reveal targets for disease control. The initiation of the immune response relies on the activation of pattern recognition receptors, among which are TLRs. Both TLR2 and TLR4 have been implicated in the recognition of P. brasiliensis and regulation of the immune response. However, the role of TLR9 during the infection by this fungus remains unclear.
publishDate 2013
dc.date.none.fl_str_mv 2013-07
2013-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/25192
url http://hdl.handle.net/1822/25192
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1935-2735
10.1371/journal.pntd.0002317
http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0002317
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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