Nutritional genomics in nonalcoholic fatty liver disease

Detalhes bibliográficos
Autor(a) principal: Vasconcellos, Carolina
Data de Publicação: 2023
Outros Autores: Ferreira, Oureana, Lopes, Marta Filipa, Ribeiro, André Filipe, Vasques, João, Guerreiro, Catarina Sousa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/62257
Resumo: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
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spelling Nutritional genomics in nonalcoholic fatty liver diseaseCHDHPEMTPNPLA3TM6SF2DietNonalcoholic fatty liver diseaseNutrigeneticsNutritionPolygenic risk score© 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).Nonalcoholic fatty liver disease (NAFLD) is a common chronic condition associated with genetic and environmental factors in which fat abnormally accumulates in the liver. NAFLD is epidemiologically associated with obesity, type 2 diabetes, and dyslipidemia. Environmental factors, such as physical inactivity and an unbalanced diet, interact with genetic factors, such as epigenetic mechanisms and polymorphisms for the genesis and development of the condition. Different genetic polymorphisms seem to be involved in this context, including variants in PNPLA3, TM6SF2, PEMT, and CHDH genes, playing a role in the disease's susceptibility, development, and severity. From carbohydrate intake and weight loss to omega-3 supplementation and caloric restriction, different dietary and nutritional factors appear to be involved in controlling the onset and progression of NAFLD conditions influencing metabolism, gene, and protein expression. The polygenic risk score represents a sum of trait-associated alleles carried by an individual and seems to be associated with NAFLD outcomes depending on the dietary context. Understanding the exact extent to which lifestyle interventions and genetic predispositions can play a role in the prevention and management of NAFLD can be crucial for the establishment of a personalized and integrative approach to patients.MDPIRepositório da Universidade de LisboaVasconcellos, CarolinaFerreira, OureanaLopes, Marta FilipaRibeiro, André FilipeVasques, JoãoGuerreiro, Catarina Sousa2024-01-26T14:29:48Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/62257engBiomedicines. 2023 Jan 23;11(2):31910.3390/biomedicines110203192227-9059info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-29T01:21:20Zoai:repositorio.ul.pt:10451/62257Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:58:40.252498Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nutritional genomics in nonalcoholic fatty liver disease
title Nutritional genomics in nonalcoholic fatty liver disease
spellingShingle Nutritional genomics in nonalcoholic fatty liver disease
Vasconcellos, Carolina
CHDH
PEMT
PNPLA3
TM6SF2
Diet
Nonalcoholic fatty liver disease
Nutrigenetics
Nutrition
Polygenic risk score
title_short Nutritional genomics in nonalcoholic fatty liver disease
title_full Nutritional genomics in nonalcoholic fatty liver disease
title_fullStr Nutritional genomics in nonalcoholic fatty liver disease
title_full_unstemmed Nutritional genomics in nonalcoholic fatty liver disease
title_sort Nutritional genomics in nonalcoholic fatty liver disease
author Vasconcellos, Carolina
author_facet Vasconcellos, Carolina
Ferreira, Oureana
Lopes, Marta Filipa
Ribeiro, André Filipe
Vasques, João
Guerreiro, Catarina Sousa
author_role author
author2 Ferreira, Oureana
Lopes, Marta Filipa
Ribeiro, André Filipe
Vasques, João
Guerreiro, Catarina Sousa
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Vasconcellos, Carolina
Ferreira, Oureana
Lopes, Marta Filipa
Ribeiro, André Filipe
Vasques, João
Guerreiro, Catarina Sousa
dc.subject.por.fl_str_mv CHDH
PEMT
PNPLA3
TM6SF2
Diet
Nonalcoholic fatty liver disease
Nutrigenetics
Nutrition
Polygenic risk score
topic CHDH
PEMT
PNPLA3
TM6SF2
Diet
Nonalcoholic fatty liver disease
Nutrigenetics
Nutrition
Polygenic risk score
description © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-01-01T00:00:00Z
2024-01-26T14:29:48Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/62257
url http://hdl.handle.net/10451/62257
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biomedicines. 2023 Jan 23;11(2):319
10.3390/biomedicines11020319
2227-9059
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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