Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate

Detalhes bibliográficos
Autor(a) principal: Lopes, Susana M. M.
Data de Publicação: 2022
Outros Autores: Lemos, Americo, Paixão, José A., Pinho e Melo, Teresa M. V. D.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/17725
Resumo: The Diels–Alder reaction of ethyl 3-(1-phenyl-1<i>H</i>-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4<i>H</i>-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7<i>H</i>-pyrano[2,3-<i>c</i>]pyridazine in quantitative yield. An X-ray crystal structure of this cycloadduct is reported.
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spelling Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylateTetrazolesDiaza-1,3-butadienePyrano[2,3-c]pyridazineMethyl vinyl ketone dimerDiels-alder reactionsX-ray structureThe Diels–Alder reaction of ethyl 3-(1-phenyl-1<i>H</i>-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4<i>H</i>-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7<i>H</i>-pyrano[2,3-<i>c</i>]pyridazine in quantitative yield. An X-ray crystal structure of this cycloadduct is reported.MDPISapientiaLopes, Susana M. M.Lemos, AmericoPaixão, José A.Pinho e Melo, Teresa M. V. D.2022-03-28T11:20:23Z2022-02-102022-03-24T14:46:47Z2022-02-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/17725engMolbank 2022 (1): M1338 (2022)1422-859910.3390/M1338info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:29:53Zoai:sapientia.ualg.pt:10400.1/17725Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:07:36.431599Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
title Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
spellingShingle Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
Lopes, Susana M. M.
Tetrazoles
Diaza-1,3-butadiene
Pyrano[2,3-c]pyridazine
Methyl vinyl ketone dimer
Diels-alder reactions
X-ray structure
title_short Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
title_full Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
title_fullStr Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
title_full_unstemmed Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
title_sort Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-7H-pyrano[2,3-c]pyridazine-1-carboxylate
author Lopes, Susana M. M.
author_facet Lopes, Susana M. M.
Lemos, Americo
Paixão, José A.
Pinho e Melo, Teresa M. V. D.
author_role author
author2 Lemos, Americo
Paixão, José A.
Pinho e Melo, Teresa M. V. D.
author2_role author
author
author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Lopes, Susana M. M.
Lemos, Americo
Paixão, José A.
Pinho e Melo, Teresa M. V. D.
dc.subject.por.fl_str_mv Tetrazoles
Diaza-1,3-butadiene
Pyrano[2,3-c]pyridazine
Methyl vinyl ketone dimer
Diels-alder reactions
X-ray structure
topic Tetrazoles
Diaza-1,3-butadiene
Pyrano[2,3-c]pyridazine
Methyl vinyl ketone dimer
Diels-alder reactions
X-ray structure
description The Diels–Alder reaction of ethyl 3-(1-phenyl-1<i>H</i>-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4<i>H</i>-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7<i>H</i>-pyrano[2,3-<i>c</i>]pyridazine in quantitative yield. An X-ray crystal structure of this cycloadduct is reported.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-28T11:20:23Z
2022-02-10
2022-03-24T14:46:47Z
2022-02-10T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/17725
url http://hdl.handle.net/10400.1/17725
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Molbank 2022 (1): M1338 (2022)
1422-8599
10.3390/M1338
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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