GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/49932 |
Resumo: | Background: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors. Methods: A total of 50 pediatric patients presenting adrenocortical tumors, including 41 clinically benign and 9 clinically malignant tumors, were included. Protein expression was evaluated using immunohistochemistry in samples arranged in tissue microarrays. Results: The immunohistochemical analysis showed a significant increase in plasma membrane expression of GLUT1 in malignant lesions, when compared to benign lesions (p=0.004), being the expression of this protein associated with shorter overall and disease-free survival (p=0.004 and p=0.001, respectively). Although significant differences were not observed for proteins other than GLUT1, MCT1, MCT4 and CD147 were highly expressed in pediatric adrenocortical neoplasias (around 90%). Conclusion: GLUT1 expression was differentially expressed in pediatric adrenocortical tumors, with higher expression in clinically malignant tumors, and associated with shorter survival, suggesting a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy. |
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GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behaviorPediatric adrenocortical tumorsMetabolic reprogrammingMonocarboxylate transporterGlucose transporterWarburg effectCiências Médicas::Medicina BásicaScience & TechnologyBackground: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors. Methods: A total of 50 pediatric patients presenting adrenocortical tumors, including 41 clinically benign and 9 clinically malignant tumors, were included. Protein expression was evaluated using immunohistochemistry in samples arranged in tissue microarrays. Results: The immunohistochemical analysis showed a significant increase in plasma membrane expression of GLUT1 in malignant lesions, when compared to benign lesions (p=0.004), being the expression of this protein associated with shorter overall and disease-free survival (p=0.004 and p=0.001, respectively). Although significant differences were not observed for proteins other than GLUT1, MCT1, MCT4 and CD147 were highly expressed in pediatric adrenocortical neoplasias (around 90%). Conclusion: GLUT1 expression was differentially expressed in pediatric adrenocortical tumors, with higher expression in clinically malignant tumors, and associated with shorter survival, suggesting a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) to Maria Claudia Nogueira Zerbini (2013/26344-8) and under the scope of the project NORTE-01-0145-FEDER-000013, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER) and by FEDER, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145-FEDER-007038info:eu-repo/semantics/publishedVersionImpact JournalsUniversidade do MinhoPinheiro, CélineGranja, Sara CostaLongatto, AdhemarFaria, André M.Fragoso, Maria C. B. V.Lovisolo, Silvana M.Bonatelli, MuriloCosta, Ricardo F.A.Lerário, Antonio M.Almeida, Madson Q.Baltazar, FátimaZerbini, Maria C.N.2017-09-032017-09-03T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/49932engPinheiro, C., Granja, S., Longatto-Filho, A., Faria, A. M., Fragoso, M. C., Lovisolo, S. M., ... & Baltazar, F. (2017). GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior. Oncotarget, 8(38), 638351949-255310.18632/oncotarget.19135http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19135&path[]=61295info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:53Zoai:repositorium.sdum.uminho.pt:1822/49932Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:46:01.277942Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
title |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
spellingShingle |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior Pinheiro, Céline Pediatric adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Glucose transporter Warburg effect Ciências Médicas::Medicina Básica Science & Technology |
title_short |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
title_full |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
title_fullStr |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
title_full_unstemmed |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
title_sort |
GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior |
author |
Pinheiro, Céline |
author_facet |
Pinheiro, Céline Granja, Sara Costa Longatto, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Bonatelli, Murilo Costa, Ricardo F.A. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, Maria C.N. |
author_role |
author |
author2 |
Granja, Sara Costa Longatto, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Bonatelli, Murilo Costa, Ricardo F.A. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, Maria C.N. |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pinheiro, Céline Granja, Sara Costa Longatto, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Bonatelli, Murilo Costa, Ricardo F.A. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, Maria C.N. |
dc.subject.por.fl_str_mv |
Pediatric adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Glucose transporter Warburg effect Ciências Médicas::Medicina Básica Science & Technology |
topic |
Pediatric adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Glucose transporter Warburg effect Ciências Médicas::Medicina Básica Science & Technology |
description |
Background: Discrimination between benign and malignant tumors is a challenging process in pediatric adrenocortical tumors. New insights in the metabolic profile of pediatric adrenocortical tumors may contribute to this distinction, predict prognosis, as well as identify new molecular targets for therapy. The aim of this work is to characterize the expression of the metabolism-related proteins MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX in a series of pediatric adrenocortical tumors. Methods: A total of 50 pediatric patients presenting adrenocortical tumors, including 41 clinically benign and 9 clinically malignant tumors, were included. Protein expression was evaluated using immunohistochemistry in samples arranged in tissue microarrays. Results: The immunohistochemical analysis showed a significant increase in plasma membrane expression of GLUT1 in malignant lesions, when compared to benign lesions (p=0.004), being the expression of this protein associated with shorter overall and disease-free survival (p=0.004 and p=0.001, respectively). Although significant differences were not observed for proteins other than GLUT1, MCT1, MCT4 and CD147 were highly expressed in pediatric adrenocortical neoplasias (around 90%). Conclusion: GLUT1 expression was differentially expressed in pediatric adrenocortical tumors, with higher expression in clinically malignant tumors, and associated with shorter survival, suggesting a metabolic remodeling towards a hyperglycolytic phenotype in this malignancy. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-09-03 2017-09-03T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/49932 |
url |
http://hdl.handle.net/1822/49932 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Pinheiro, C., Granja, S., Longatto-Filho, A., Faria, A. M., Fragoso, M. C., Lovisolo, S. M., ... & Baltazar, F. (2017). GLUT1 expression in pediatric adrenocortical tumors: a promising candidate to predict clinical behavior. Oncotarget, 8(38), 63835 1949-2553 10.18632/oncotarget.19135 http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19135&path[]=61295 |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Impact Journals |
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Impact Journals |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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