Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
Autor(a) principal: | |
---|---|
Data de Publicação: | 2015 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/45142 |
Resumo: | Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis. |
id |
RCAP_956096be96ec0402f8c95a0120970f07 |
---|---|
oai_identifier_str |
oai:repositorium.sdum.uminho.pt:1822/45142 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumorsAdrenocortical tumorsMetabolic reprogrammingMonocarboxylate transporterWarburg effectScience & TechnologyAdrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis.This work was supported by FAPESP to Maria Claudia Nogueira Zerbini (2013-26344-8). SG received the post-doctoral fellowship UMINHO/BPD/18/2014.info:eu-repo/semantics/publishedVersionImpact Journals LLCUniversidade do MinhoPinheiro, CelinaGranja, Sara CostaLongatto Filho, AdhemarFaria, André M.Fragoso, Maria C. B. V.Lovisolo, Silvana M.Lerário, Antonio M.Almeida, Madson Q.Baltazar, FátimaZerbini, M. C. N.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45142eng1949-255310.18632/oncotarget.562326587828http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=5623&path%5B%5D=17566info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:32Zoai:repositorium.sdum.uminho.pt:1822/45142Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:10.779458Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
title |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
spellingShingle |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors Pinheiro, Celina Adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Warburg effect Science & Technology |
title_short |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
title_full |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
title_fullStr |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
title_full_unstemmed |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
title_sort |
Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors |
author |
Pinheiro, Celina |
author_facet |
Pinheiro, Celina Granja, Sara Costa Longatto Filho, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, M. C. N. |
author_role |
author |
author2 |
Granja, Sara Costa Longatto Filho, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, M. C. N. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Pinheiro, Celina Granja, Sara Costa Longatto Filho, Adhemar Faria, André M. Fragoso, Maria C. B. V. Lovisolo, Silvana M. Lerário, Antonio M. Almeida, Madson Q. Baltazar, Fátima Zerbini, M. C. N. |
dc.subject.por.fl_str_mv |
Adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Warburg effect Science & Technology |
topic |
Adrenocortical tumors Metabolic reprogramming Monocarboxylate transporter Warburg effect Science & Technology |
description |
Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/45142 |
url |
http://hdl.handle.net/1822/45142 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1949-2553 10.18632/oncotarget.5623 26587828 http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=5623&path%5B%5D=17566 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Impact Journals LLC |
publisher.none.fl_str_mv |
Impact Journals LLC |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799132422683492352 |