Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors

Detalhes bibliográficos
Autor(a) principal: Pinheiro, Celina
Data de Publicação: 2015
Outros Autores: Granja, Sara Costa, Longatto Filho, Adhemar, Faria, André M., Fragoso, Maria C. B. V., Lovisolo, Silvana M., Lerário, Antonio M., Almeida, Madson Q., Baltazar, Fátima, Zerbini, M. C. N.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/45142
Resumo: Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis.
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spelling Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumorsAdrenocortical tumorsMetabolic reprogrammingMonocarboxylate transporterWarburg effectScience & TechnologyAdrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis.This work was supported by FAPESP to Maria Claudia Nogueira Zerbini (2013-26344-8). SG received the post-doctoral fellowship UMINHO/BPD/18/2014.info:eu-repo/semantics/publishedVersionImpact Journals LLCUniversidade do MinhoPinheiro, CelinaGranja, Sara CostaLongatto Filho, AdhemarFaria, André M.Fragoso, Maria C. B. V.Lovisolo, Silvana M.Lerário, Antonio M.Almeida, Madson Q.Baltazar, FátimaZerbini, M. C. N.20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/45142eng1949-255310.18632/oncotarget.562326587828http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=5623&path%5B%5D=17566info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:10:32Zoai:repositorium.sdum.uminho.pt:1822/45142Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:02:10.779458Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
title Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
spellingShingle Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
Pinheiro, Celina
Adrenocortical tumors
Metabolic reprogramming
Monocarboxylate transporter
Warburg effect
Science & Technology
title_short Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
title_full Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
title_fullStr Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
title_full_unstemmed Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
title_sort Metabolic reprogramming: a new relevant pathway in adult adrenocortical tumors
author Pinheiro, Celina
author_facet Pinheiro, Celina
Granja, Sara Costa
Longatto Filho, Adhemar
Faria, André M.
Fragoso, Maria C. B. V.
Lovisolo, Silvana M.
Lerário, Antonio M.
Almeida, Madson Q.
Baltazar, Fátima
Zerbini, M. C. N.
author_role author
author2 Granja, Sara Costa
Longatto Filho, Adhemar
Faria, André M.
Fragoso, Maria C. B. V.
Lovisolo, Silvana M.
Lerário, Antonio M.
Almeida, Madson Q.
Baltazar, Fátima
Zerbini, M. C. N.
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pinheiro, Celina
Granja, Sara Costa
Longatto Filho, Adhemar
Faria, André M.
Fragoso, Maria C. B. V.
Lovisolo, Silvana M.
Lerário, Antonio M.
Almeida, Madson Q.
Baltazar, Fátima
Zerbini, M. C. N.
dc.subject.por.fl_str_mv Adrenocortical tumors
Metabolic reprogramming
Monocarboxylate transporter
Warburg effect
Science & Technology
topic Adrenocortical tumors
Metabolic reprogramming
Monocarboxylate transporter
Warburg effect
Science & Technology
description Adrenocortical carcinomas (ACCs) are complex neoplasias that may present unexpected clinical behavior, being imperative to identify new biological markers that can predict patient prognosis and provide new therapeutic options. The main aim of the present study was to evaluate the prognostic value of metabolism-related key proteins in adrenocortical carcinoma. The immunohistochemical expression of MCT1, MCT2, MCT4, CD147, CD44, GLUT1 and CAIX was evaluated in a series of 154 adult patients with adrenocortical neoplasia and associated with patients’ clinicopathological parameters. A significant increase in was found for membranous expression of MCT4, GLUT1 and CAIX in carcinomas, when compared to adenomas. Importantly MCT1, GLUT1 and CAIX expressions were significantly associated with poor prognostic variables, including high nuclear grade, high mitotic index, advanced tumor staging, presence of metastasis, as well as shorter overall and disease free survival. In opposition, MCT2 membranous expression was associated with favorable prognostic parameters. Importantly, cytoplasmic expression of CD147 was identified as an independent predictor of longer overall survival and cytoplasmic expression of CAIX as an independent predictor of longer disease-free survival. We provide evidence for a metabolic reprogramming in adrenocortical malignant tumors towards the hyperglycolytic and acid-resistant phenotype, which was associated with poor prognosis.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/45142
url http://hdl.handle.net/1822/45142
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1949-2553
10.18632/oncotarget.5623
26587828
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=5623&path%5B%5D=17566
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publisher.none.fl_str_mv Impact Journals LLC
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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