Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles

Detalhes bibliográficos
Autor(a) principal: Mora, Blanca de Juan
Data de Publicação: 2021
Outros Autores: Filipe, Luís, Forte, Andreia, Santos, Miguel M., Alves, Celso, Teodoro, Fernando, Pedrosa, Rui, Carrott, Manuela Ribeiro, Branco, Luís C., Gago, Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/142688
Resumo: UID/MAR/04292/2020 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012 MAR-02.01.01-FEAMP-0042–INOVA4AQUA 022161
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spelling Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticlesAntimicrobial activityCiprofloxacinCytotoxicityIonic liquidsMesoporous silica nanoparticlesPharmaceutical ScienceUID/MAR/04292/2020 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012 MAR-02.01.01-FEAMP-0042–INOVA4AQUA 022161Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanomaterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.DQ - Departamento de QuímicaLAQV@REQUIMTERUNMora, Blanca de JuanFilipe, LuísForte, AndreiaSantos, Miguel M.Alves, CelsoTeodoro, FernandoPedrosa, RuiCarrott, Manuela RibeiroBranco, Luís C.Gago, Sandra2022-07-29T22:24:32Z2021-02-052021-02-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article16application/pdfhttp://hdl.handle.net/10362/142688eng1999-4923PURE: 45529886https://doi.org/10.3390/pharmaceutics13020218info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:20:33Zoai:run.unl.pt:10362/142688Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:50:28.426731Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
spellingShingle Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
Mora, Blanca de Juan
Antimicrobial activity
Ciprofloxacin
Cytotoxicity
Ionic liquids
Mesoporous silica nanoparticles
Pharmaceutical Science
title_short Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_full Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_fullStr Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_full_unstemmed Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_sort Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
author Mora, Blanca de Juan
author_facet Mora, Blanca de Juan
Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
author_role author
author2 Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Mora, Blanca de Juan
Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
dc.subject.por.fl_str_mv Antimicrobial activity
Ciprofloxacin
Cytotoxicity
Ionic liquids
Mesoporous silica nanoparticles
Pharmaceutical Science
topic Antimicrobial activity
Ciprofloxacin
Cytotoxicity
Ionic liquids
Mesoporous silica nanoparticles
Pharmaceutical Science
description UID/MAR/04292/2020 PEst-C/LA0006/2013 RECI/BBBBQB/0230/2012 MAR-02.01.01-FEAMP-0042–INOVA4AQUA 022161
publishDate 2021
dc.date.none.fl_str_mv 2021-02-05
2021-02-05T00:00:00Z
2022-07-29T22:24:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/142688
url http://hdl.handle.net/10362/142688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1999-4923
PURE: 45529886
https://doi.org/10.3390/pharmaceutics13020218
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 16
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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