Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles

Detalhes bibliográficos
Autor(a) principal: Juan Mora, Blanca de
Data de Publicação: 2021
Outros Autores: Filipe, Luís, Forte, Andreia, Santos, Miguel M., Alves, Celso, Teodoro, Fernando, Pedrosa, Rui, Carrott, Manuela Ribeiro, Branco, Luís C., Gago, Sandra
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.8/5992
Resumo: The authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively)
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spelling Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticlesCiprofloxacinIonic liquidsMesoporous silica nanoparticlesCytotoxicityAntimicrobial activityThe authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively)Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanom aterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.MDPIIC-OnlineJuan Mora, Blanca deFilipe, LuísForte, AndreiaSantos, Miguel M.Alves, CelsoTeodoro, FernandoPedrosa, RuiCarrott, Manuela RibeiroBranco, Luís C.Gago, Sandra2021-08-03T12:03:14Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5992engde Juan Mora, B.; Filipe, L.; Forte, A.; Santos, M.M.; Alves, C.; Teodoro, F.; Pedrosa, R.; Ribeiro Carrott, M.; Branco, L.C.; Gago, S. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218. https:// doi.org/10.3390/pharmaceutics130202181999-492310.3390/pharmaceutics13020218info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-17T15:52:07Zoai:iconline.ipleiria.pt:10400.8/5992Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:49:19.940287Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
spellingShingle Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
Juan Mora, Blanca de
Ciprofloxacin
Ionic liquids
Mesoporous silica nanoparticles
Cytotoxicity
Antimicrobial activity
title_short Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_full Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_fullStr Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_full_unstemmed Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
title_sort Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
author Juan Mora, Blanca de
author_facet Juan Mora, Blanca de
Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
author_role author
author2 Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv IC-Online
dc.contributor.author.fl_str_mv Juan Mora, Blanca de
Filipe, Luís
Forte, Andreia
Santos, Miguel M.
Alves, Celso
Teodoro, Fernando
Pedrosa, Rui
Carrott, Manuela Ribeiro
Branco, Luís C.
Gago, Sandra
dc.subject.por.fl_str_mv Ciprofloxacin
Ionic liquids
Mesoporous silica nanoparticles
Cytotoxicity
Antimicrobial activity
topic Ciprofloxacin
Ionic liquids
Mesoporous silica nanoparticles
Cytotoxicity
Antimicrobial activity
description The authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively)
publishDate 2021
dc.date.none.fl_str_mv 2021-08-03T12:03:14Z
2021
2021-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.8/5992
url http://hdl.handle.net/10400.8/5992
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv de Juan Mora, B.; Filipe, L.; Forte, A.; Santos, M.M.; Alves, C.; Teodoro, F.; Pedrosa, R.; Ribeiro Carrott, M.; Branco, L.C.; Gago, S. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218. https:// doi.org/10.3390/pharmaceutics13020218
1999-4923
10.3390/pharmaceutics13020218
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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