Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.8/5992 |
Resumo: | The authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively) |
id |
RCAP_c2e9c587ab71aeb2b2d58a3598d4134b |
---|---|
oai_identifier_str |
oai:iconline.ipleiria.pt:10400.8/5992 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticlesCiprofloxacinIonic liquidsMesoporous silica nanoparticlesCytotoxicityAntimicrobial activityThe authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively)Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution 1H NMR spectroscopies, elemental analysis, XRD and N2 adsorption at 77 K in order to provide the desired structures. No cytotoxicity from the prepared mesoporous nanoparticles on 3T3 murine fibroblasts was observed. The antimicrobial activity of the nanomaterials was determined against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Klebsiella pneumoniae) bacteria and the results were promising against S. aureus. In the case of B. subtilis, both nanom aterials exhibited higher antimicrobial activity than the precursor [Ch][Cip], and in the case of K. pneumoniae they exhibited higher activity than neutral ciprofloxacin.MDPIIC-OnlineJuan Mora, Blanca deFilipe, LuísForte, AndreiaSantos, Miguel M.Alves, CelsoTeodoro, FernandoPedrosa, RuiCarrott, Manuela RibeiroBranco, Luís C.Gago, Sandra2021-08-03T12:03:14Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.8/5992engde Juan Mora, B.; Filipe, L.; Forte, A.; Santos, M.M.; Alves, C.; Teodoro, F.; Pedrosa, R.; Ribeiro Carrott, M.; Branco, L.C.; Gago, S. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218. https:// doi.org/10.3390/pharmaceutics130202181999-492310.3390/pharmaceutics13020218info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-09-26T18:19:54Zoai:iconline.ipleiria.pt:10400.8/5992Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-09-26T18:19:54Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
title |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
spellingShingle |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles Juan Mora, Blanca de Ciprofloxacin Ionic liquids Mesoporous silica nanoparticles Cytotoxicity Antimicrobial activity |
title_short |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
title_full |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
title_fullStr |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
title_full_unstemmed |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
title_sort |
Boosting antimicrobial activity of ciprofloxacin by functionalization of mesoporous silica nanoparticles |
author |
Juan Mora, Blanca de |
author_facet |
Juan Mora, Blanca de Filipe, Luís Forte, Andreia Santos, Miguel M. Alves, Celso Teodoro, Fernando Pedrosa, Rui Carrott, Manuela Ribeiro Branco, Luís C. Gago, Sandra |
author_role |
author |
author2 |
Filipe, Luís Forte, Andreia Santos, Miguel M. Alves, Celso Teodoro, Fernando Pedrosa, Rui Carrott, Manuela Ribeiro Branco, Luís C. Gago, Sandra |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
IC-Online |
dc.contributor.author.fl_str_mv |
Juan Mora, Blanca de Filipe, Luís Forte, Andreia Santos, Miguel M. Alves, Celso Teodoro, Fernando Pedrosa, Rui Carrott, Manuela Ribeiro Branco, Luís C. Gago, Sandra |
dc.subject.por.fl_str_mv |
Ciprofloxacin Ionic liquids Mesoporous silica nanoparticles Cytotoxicity Antimicrobial activity |
topic |
Ciprofloxacin Ionic liquids Mesoporous silica nanoparticles Cytotoxicity Antimicrobial activity |
description |
The authors also thank Fundação para a Ciência e Tecnologia for the projects PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013, RECI/BBBBQB/0230/2012 as well as MAR2020 (MAR-02.01.01-FEAMP-0042–INOVA4AQUA). The NMR spectrometers are part of the National NMR Network (PTNMR) and are partially supported by Infrastructure Project N◦ 022161 (co-financed by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC). This work was supported by the Associate Laboratory for Green Chemistry LAQV and MARE—Marine and Environmental Sciences Centre which are financed by national funds from FCT/MCTES (UIDB/50006/2020 and UID/MAR/04292/2020, respectively) |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-03T12:03:14Z 2021 2021-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.8/5992 |
url |
http://hdl.handle.net/10400.8/5992 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
de Juan Mora, B.; Filipe, L.; Forte, A.; Santos, M.M.; Alves, C.; Teodoro, F.; Pedrosa, R.; Ribeiro Carrott, M.; Branco, L.C.; Gago, S. Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles. Pharmaceutics 2021, 13, 218. https:// doi.org/10.3390/pharmaceutics13020218 1999-4923 10.3390/pharmaceutics13020218 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
_version_ |
1817547268394319872 |